Results 81 to 90 of about 2,123,606 (402)
Thymoma and Thymic Carcinoma: Molecular Pathology and Targeted Therapy [PDF]
, 2010 :Thymomas and thymic carcinomas (TC) are rare epithelial tumors of the thymus. Although most thymomas have organotypic features (i.e., resemble the normal thymus), TC are morphologically undistinguishable from carcinomas in other organs. Apart from their
Hohenberger, Peter +2 more
core +1 more source
Adaptation and learning of molecular networks as a description of cancer development at the systems-level: Potential use in anti-cancer therapies [PDF]
Seminars in Cancer Biology 23 (2013) 262-269, 2013 There is a widening recognition that cancer cells are products of complex developmental processes. Carcinogenesis and metastasis formation are increasingly described as systems-level, network phenomena. Here we propose that malignant transformation is a two-phase process, where an initial increase of system plasticity is followed by a decrease of ...
arxiv +1 more source
Molecular Targets in Hepatocarcinogenesis and Implications for Therapy [PDF]
Journal of Clinical Medicine, 2018 Hepatocarcinogenesis comprises of multiple, complex steps that occur after liver injury and usually involve several pathways, including telomere dysfunction, cell cycle, WNT/β-catenin signaling, oxidative stress and mitochondria dysfunction, autophagy, apoptosis, and AKT/mTOR signaling.
Meng-Yu Wu +4 more
openaire +3 more sources
Review of precision cancer medicine: Evolution of the treatment paradigm. [PDF]
, 2020 In recent years, biotechnological breakthroughs have led to identification of complex and unique biologic features associated with carcinogenesis. Tumor and cell-free DNA profiling, immune markers, and proteomic and RNA analyses are used to identify ...
Fountzilas, Elena +3 more
core +1 more source
Intensive Care Medicine, 2019 BackgroundMolecular targeted therapy increased overall and disease-free survival in a wide range of malignancies. Although generally well tolerated compared to chemotherapy, molecular targeted therapy may be associated with adverse events requiring ICU ...
S. Assoun, V. Lemiale, É. Azoulay
semanticscholar +1 more source
Radiation-induced myeloid leukemia in murine models. [PDF]
, 2014 The use of radiation therapy is a cornerstone of modern cancer treatment. The number of patients that undergo radiation as a part of their therapy regimen is only increasing every year, but this does not come without cost.
Davoren, Michael +2 more
core +2 more sources
scRNA-seq reveals ATPIF1 activity in control of T cell antitumor activity
OncoImmunology, 2022 ATP synthase inhibitory factor 1 (ATPIF1) is a mitochondrial protein with an activity in inhibition of F1Fo-ATP synthase. ATPIF1 activity remains unknown in the control of immune activity of T cells.
Genshen Zhong +12 more
doaj +1 more source
Molecular targeted therapy for the treatment of gastric cancer
Journal of experimental & clinical cancer research : CR, 2016 Despite the global decline in the incidence and mortality of gastric cancer, it remains one of the most common malignant tumors of the digestive system.
Wenting Xu, Zhen Yang, N. Lu
semanticscholar +1 more source
Advancements in clinical aspects of targeted therapy and immunotherapy in breast cancer
Molecular Cancer, 2023 Breast cancer is the second leading cause of death for women worldwide. The heterogeneity of this disease presents a big challenge in its therapeutic management.
Feng Ye +9 more
semanticscholar +1 more source
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source