Results 131 to 140 of about 10,024 (235)

Effect of molnupiravir on SARS-CoV-2 evolution in immunocompromised patients: a retrospective observational study.

The Lancet Microbe
INTRODUCTION Continued SARS-CoV-2 infection among immunocompromised individuals is likely to play a role in generating genomic diversity and the emergence of novel variants.
N. Fountain‐Jones, Robert Vanhaeften, J. Williamson, Janelle Maskell, I-Ly J Chua, Michael Charleston, Louise Cooley   +6 more
semanticscholar   +1 more source

Garlic peel-based carbon quantum dots as a sustainable alternative for the sensitive and green spectrofluorometric quantification of molnupiravir in pharmaceutical capsules

Heliyon
Searching for natural alternatives to replace environmentally harmful chemical reagents in analysis is just as crucial as finding easily accessible analytical tools.
Yomna A. Saber, Mahmoud Hamed, Samy Emara, Fotouh R. Mansour, Marcello Locatelli, Noha Ibrahim   +5 more
doaj   +1 more source

Clinical Outcome and 7-Day Virological Clearance in High-Risk Patients with Mild–Moderate COVID-19 Treated with Molnupiravir, Nirmatrelvir/Ritonavir, or Remdesivir [PDF]

Introduction: We compared the effectiveness and virological clearance (VC) at day 7 (T7) post-treatment with molnupiravir, nirmatrelvir/ritonavir, and remdesivir in SARS-CoV-2-infected patients at high risk (HR) for clinical progression. Methods: We
Albertini, Lorenzo, Augello, Matteo, Bai, Francesca, Beringheli, Tomaso, Biasioli, Lorenzo, Bini, Teresa, Bono, Valeria, Castoldi, Roberto, Copes, Alessandro, Gemignani, Nicole, Ligresti, Riccardo, Lundgren, Lorenzo Brando, Marchetti, Giulia, Molà, Francesco, Monforte, Antonella d'Arminio, Nardo, Riccardo, Orfeo, Nicola Vincenzo, Passarella, Sabrina, Pettenuzzo, Sofia, Rovito, Roberta, Sala, Matteo, Santoro, Andrea, Varisco, Benedetta, Vitaletti, Virginia   +23 more
core   +1 more source

Synergistic interference with SARS-CoV-2 replication by molnupiravir-derived N⁴-hydroxycytidine and inhibitors of CTP synthetase in cell culture [PDF]

N4-hydroxycytidine (NHC), the active metabolite of molnupiravir, is incorporated into nascent RNA of SARS-CoV-2 and interferes with subsequent virus replication.
Balkema-Buschmann, A., Baumgärtner, W., Beer, P., Dickmanns, A., Dobbelstein, M., Fuchs, H., Meyer zu Natrup, C., Moeselaken, F., Mohl, B., Parker, A., Pilchova, V., Reineking, W., Scheibner, D., Stegmann, K., Störk, T., Volz, A., von Köckritz-Blickwede, M.   +16 more
core   +2 more sources

Synthesis of Molnupiravir [PDF]

Synfacts, 2022
openaire   +1 more source

Comparison of azvudine, molnupiravir, and nirmatrelvir/ritonavir in adult patients with mild-to-moderate COVID-19: a retrospective cohort study

Scientific Reports
This study aimed to explore the effectiveness and safety of azvudine, nirmatrelvir/ritonavir, and molnupiravir in adult patients with mild-to-moderate COVID-19.
Mei-Ping Chen, Di-Xuan Jiang, Jia-Xi Rang, Hai-Bo Zhuo, Zhi-Guo Zhou   +4 more
doaj   +1 more source

Genetic consequences of effective and suboptimal dosing with mutagenic drugs in a hamster model of SARS-CoV-2 infection [PDF]

Mutagenic antiviral drugs have shown promise against multiple viruses, but concerns have been raised about whether their use might promote the emergence of new and harmful viral variants. Recently, genetic signatures associated with molnupiravir use have
Abdelnabi, Rana, Breuer, Judith, Charles, Oscar, Gregg, Samuel, Guerra-Assuncao, Jose A, Illingworth, Christopher JR, Neyts, Johan, Pang, Juanita, Roy, Sunando   +8 more
core  

Novel green UPLC method with life cycle assessment for determination of favipiravir and molnupiravir drugs and environmental water samples. [PDF]

Sci Rep
Kelani KM, Elsherbiny MS, Eid SM, Ghany MFA, Abbas MM.   +4 more
europepmc   +1 more source

Using Twitter Data to Understand Public Perceptions of Approved versus Off-label Use for COVID-19-related Medications

Understanding public discourse on emergency use of unproven therapeutics is crucial for monitoring safe use and combating misinformation. We developed a natural language processing-based pipeline to comprehend public perceptions of and stances on ...
Bates, David W., Hua, Yining, Jiang, Hang, Lin, Shixu, Plasek, Joseph M., Yang, Jie, Zhou, Li   +6 more
core   +1 more source

Patterns of use of oral antivirals for COVID-19 in people 70 years and over in Victoria, Australia: a linked data study. [PDF]

BMC Infect Dis
Edwards LJ, Scaria A, Cheng AC, Amin J, Robinson EJ, Sumpton C, Liu B.   +6 more
europepmc   +1 more source