Results 111 to 120 of about 6,560 (205)

Comprehensive genotoxicity and carcinogenicity assessment of molnupiravir

Toxicological Sciences
Abstract Molnupiravir is registered or authorized in several countries as a 5-d oral coronavirus disease 2019 treatment for adults. Molnupiravir is a prodrug of the antiviral ribonucleoside β-D-N4-hydroxycytidine (NHC) that distributes into cells, where it is phosphorylated to its pharmacologically active ribonucleoside triphosphate (NHC-
Patricia A Escobar, Zhanna Sobol, Randy R Miller, Sandrine Ferry-Martin, Angela Stermer, Binod Jacob, Nagaraja Muniappa, Rosa I Sanchez, Kerry T Blanchard, Alema Galijatovic-Idrizbegovic, Rupesh P Amin, Sean P Troth   +11 more
openaire   +2 more sources

Prevention is better than healing. Clinical and economic implications of oral antiviral agents in COVID-19: a prospective study

Italian Journal of Medicine
COVID-19 represents a threat for frailty patients. This study compares molnupiravir and nirmatrelvir for fragile COVID- 19 patients' efficacy, safety, and cost.
Filomena Pietrantonio, Francesco Rosiello, Matteo Ruggeri, Maria Sofia Cattaruzza, Antonio Vinci, Margherita Lordi, Enrica Cipriano   +6 more
doaj   +1 more source

Cost-effectiveness Analysis of Nirmatrelvir/Ritonavir Compared with Molnupiravir in Patients at High Risk for Progression to Severe COVID-19 in Japan

Journal of Health Economics and Outcomes Research
# Background Nirmatrelvir/ritonavir (NMV/r) and molnupiravir are oral antiviral drugs approved for the treatment of early symptomatic patients with mild to moderate COVID-19 at high risk of progression to severe disease in Japan.
Akira Yuasa, Hiroyuki Matsuda, Yosuke Fujii, Tendai Mugwagwa, Yuki Kado, Mizuki Yoshida, Koichi Murata, Yoshiaki Gu   +7 more
doaj   +1 more source

Effect of Nucleic Acid Analog Administration on Fluctuations in the Albumin-to-Globulin Ratio in Cats with Feline Infectious Peritonitis

Animals
Background: feline infectious peritonitis (FIP) is a fatal disease in cats classified as either effusive (‘wet’), non-effusive (‘dry’), or a mixture of both forms (‘mixed’).
Masato Katayama, Yukina Uemura, Daichi Katori   +2 more
doaj   +1 more source

Synthesis of Molnupiravir [PDF]

Synfacts, 2022
openaire   +1 more source

A Phase 2a, Randomized, Placebo-Controlled Human Challenge Trial to Evaluate the Efficacy and Safety of Molnupiravir in Healthy Participants Inoculated with Respiratory Syncytial Virus

Pulmonary Therapy
Introduction Human respiratory syncytial virus (RSV) infections can result in hospitalization and/or death among vulnerable populations. Molnupiravir is a prodrug of ß-D-N4-hydroxycytidine, which has broad-spectrum preclinical activity against RNA ...
Mickie H. Cheng, Alex J. Mann, Brian M. Maas, Tian Zhao, Melissa Bevan, Andrea K. Schaeffer, Laura E. Liao, Andrew P. Catchpole, David W. Hilbert, S. Aubrey Stoch, Carisa S. De Anda   +10 more
doaj   +1 more source

Expedient Synthesis of Antiviral Drug Molnupiravir from D-Ribose and Cytosine

Molnupiravir, an approved antiviral drug for treating SARS-CoV-2-infected patients, presents a critical need for a concise and sustainable synthesis from readily available raw materials due to its potential high demand. Herein, we report a cost-effective
Jayashree, Rajput, Srinivas, Hotha, Saptashwa , Chakraborty, Yogesh, Sutar, Kameshwar, Prasad   +4 more
core   +1 more source

Comparison of azvudine, molnupiravir, and nirmatrelvir/ritonavir in adult patients with mild-to-moderate COVID-19: a retrospective cohort study

Scientific Reports
This study aimed to explore the effectiveness and safety of azvudine, nirmatrelvir/ritonavir, and molnupiravir in adult patients with mild-to-moderate COVID-19.
Mei-Ping Chen, Di-Xuan Jiang, Jia-Xi Rang, Hai-Bo Zhuo, Zhi-Guo Zhou   +4 more
doaj   +1 more source

Molnupiravir is effective against hepatitis E virus infection in an animal model. [PDF]

Hepatol Commun
Wu S, Chew NF, Ma X, Situ J, Shun EH, Li C, Ip JD, Ho SS, Zhang AJ, Tsoi JY, Chan WM, Ma W, Liang Y, Mao W, Chen KWY, Yin F, To KK, Yuan S, Chan JF, Zhu L, Huang Y, Sridhar S.   +21 more
europepmc   +1 more source

<i>Boesenbergia rotunda</i>-Derived Phytochemicals as Potent Inhibitors of SARS-CoV-2 Papain-Like Protease (PLpro): Insights From Molecular Docking and Dynamic Simulation. [PDF]

Scientifica (Cairo)
Khan DA, Sheikh MA, Imon RR, Imtiaz M, Ahmed S, Gharami H, Labana RV, Jimoh TO, Gaurav A, Pereira ML, Nawaz M, Dungca JZ, Hasan MN, Ghosh M, Nissapatorn V.   +14 more
europepmc   +1 more source