Cost-utility analysis of molnupiravir plus usual care versus usual care alone as early treatment for community-based adults with COVID-19 and increased risk of adverse outcomes in the UK PANORAMIC trial [PDF]
BACKGROUND: The cost-effectiveness of molnupiravir, an oral antiviral for early treatment of SARS-CoV-2, has not been established in vaccinated populations.
Ahmed, Haroon +31 more
core +2 more sources
Uncovering the mode of action of small molecule inhibitors against the RNA polymerase of SARS-CoV-2 [PDF]
Boehringer Ingelheim Fonds (BIF)Severe acute respiratory syndrome coronavirus 2 (SARS CoV 2) is the causative agent of coronavirus disease 2019 (COVID-19).
Kabinger, Florian
core +1 more source
Frontiers in Veterinary ScienceAlthough not registered for feline infectious peritonitis (FIP) in Japan, nucleoside analogs have shown efficacy and we have been offering them to owners of cats with FIP at our clinic since January 2020. The aim of this study was to investigate outcomes
Okihiro Sase +3 more
doaj +1 more source
Elucidation of the DNA repair mechanisms involved in the repair of DNA damage caused by the Arabinosides and Anti-COVID-19 drugs [PDF]
東京都立大学Tokyo Metropolitan University博士（理学）doctoral ...
RAHMAN, Md Ratul +1 more
core
Molnupiravir: Mechanism of action, clinical, and translational science
Clinical and Translational ScienceMolnupiravir is an oral prodrug of the broadly active, antiviral ribonucleoside analog N‐hydroxycytidine (NHC). The primary circulating metabolite NHC is taken up into cells and phosphorylated to NHC‐triphosphate (NHC‐TP).
Brian M. Maas +9 more
doaj +1 more source
Molnupiravir for the treatment of COVID-19 outpatients: An updated meta-analysis
Journal of Microbiology, Immunology and InfectionBackground: The majority of available data on molnupiravir come from an unvaccinated COVID-19 population. Therefore, we conducted this meta-analysis to integrate evidence from recent randomized controlled trials (RCTs) as well as observational studies ...
Huzaifa Ahmad Cheema +8 more
doaj +1 more source
Genetic consequences of effective and suboptimal dosing with mutagenic drugs in a hamster model of SARS-CoV-2 infection [PDF]
Mutagenic antiviral drugs have shown promise against multiple viruses, but concerns have been raised about whether their use might promote the emergence of new and harmful viral variants. Recently, genetic signatures associated with molnupiravir use have
Abdelnabi, Rana +8 more
core
Molnupiravir or nirmatrelvir-ritonavir versus usual care in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial [PDF]
Background: Molnupiravir and nirmatrelvir-ritonavir (Paxlovid) are oral antivirals that have been proposed as treatments for patients admitted to hospital with COVID-19.
Amuasi, John +39 more
core +2 more sources
Understanding public discourse on emergency use of unproven therapeutics is crucial for monitoring safe use and combating misinformation. We developed a natural language processing-based pipeline to comprehend public perceptions of and stances on ...
Bates, David W. +6 more
core +1 more source