Results 91 to 100 of about 6,560 (205)
ChemMedChem, Volume 21, Issue 9, 14 May 2026.In our study, we obtained both non‐covalent and covalent PLpro inhibitors. Additionally, the stable protein‐ligand interactions of the active compound were examined using advanced computational docking and molecular dynamics simulations. The non‐covalent inhibitor 2t showed antiviral activity with an EC50 of 2.89 µM, indicating its potential as a ...
Elena‐Oriana Iuga +11 more
wiley +1 more source
DFT and Molecular Docking Studies of an Antiviral Drug: Molnupiravir
, 2023 810-812This paper presents computational analysis of molnupiravir, the first orally administered antiviral drug approved by MHRA for the cure of COVID-19.
Mishra, Abhinav +2 more
core +1 more source
Carbohydrate‐Based Drug Discovery: Synthetic Strategies and Clinical Applications
Israel Journal of Chemistry, Volume 66, Issue 3, May 2026.The picture depicts the molecules discussed in the review. On the left side, the general scaffold of sugars is shown. Next to it are four carbohydrate‐based molecules, including remdesivir, islatravir, empagliflozin, and Globo‐H. Remdesivir and islatravir contain a substituted ribose ring attached to a modified nucleobase.
Stephan Scheeff +2 more
wiley +1 more source
Molnupiravir: From Hope to Epic Fail?
, 2022 Molnupiravir has been the first oral antiviral authorized for COVID-19 outpatients, reporting extraordinary sales and preserved in vitro efficacy against Omicron sublineages so far.
Daniele Focosi, Focosi, Daniele
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Small Molecule Inhibition of Mononegavirales RNA Polymerases
Journal of Medical Virology, Volume 98, Issue 5, May 2026.ABSTRACT The order Mononegavirales includes several non‐segmented negative‐sense RNA viruses that are significant human pathogens, whose transcription and replication depend on multifunctional RNA‐dependent RNA polymerase (L protein). Recent discoveries in cryo‐electron microscopy (cryo‐EM) have elucidated the structures of these polymerases and their ...
Claire R. Cao +3 more
wiley +1 more source
Fact sheet for Molnupiravir. Arabic
, 2021 Title from PDF caption (viewed on January 4, 2022)."OHA4029C12292021 ARABIC"--Running footer.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program.
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Microbial Biotechnology, Volume 19, Issue 5, May 2026.Chemical structure of RIBOTAC inhibitor with metabolic handle binding as nucleotide analogue to SARS‐CoV‐2 RNA dependent RNA polymerase, its linker and the RNase L recruiter which binds RNase L monomers and mediates their dimerization that actives nuclease activity degrading the viral RNA.
Harald Brüssow
wiley +1 more source
Fact sheet for Molnupiravir. Chuukese
, 2021 Title from PDF caption (viewed on January 4, 2022)."OHA4029C12292021 CHUUKESE"--Running footer.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program.
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Bioluminescence imaging reveals enhanced SARS-CoV-2 clearance in mice with combinatorial regimens
iScienceSummary: Direct acting antivirals (DAAs) represent critical tools for combating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) that have escaped vaccine-elicited spike-based immunity and future coronaviruses with ...
Irfan Ullah +13 more
doaj +1 more source
Nirmatrelvir or Molnupiravir Use and Severe Outcomes From Omicron Infections
, 2023 Importance: Ritonavir-boosted nirmatrelvir and molnupiravir are currently used in the US and in other countries to treat nonhospitalized patients who have mild-to-moderate COVID-19 and who are at high risk for progression to severe disease.
Lin, Dan-Yu +7 more
core +1 more source