Results 61 to 70 of about 6,976 (207)

Molnupiravir. Russian

, 2021
Title from PDF caption (viewed on January 4, 2022)."OHA4029A12292021 RUSSIAN"--Running footer.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may

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4′‐ThioRNA Substitution and Sense‐Strand Segmentation for the Design of Functional Fully Modified siRNAs Targeting SARS‐CoV‐2

Chemistry – A European Journal, EarlyView.
4′‐ThioRNA was broadly tolerated across multiple positions in SARS‐CoV‐2‐targeting siRNAs, but full 4'‐thio modification of both strands caused a reduction in RNAi activity. Sense‐strand segmentation improved RNAi and antiviral activity, particularly when the nick was located at position 10 from the 5′‐end of the sense strand, thereby unlocking the ...
Yuhei Nogi, Jun Tsukimoto, Noriko Saito‐Tarashima, Takaaki Koma, Masako Nomaguchi, Noriaki Minakawa   +5 more
wiley   +1 more source

Molnupiravir. Arabic

, 2021
Title from PDF caption (viewed on January 4, 2022)."OHA4029A12292021 ARABIC"--Running footer.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program.

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Evolving to an Ideal Synthesis of Molnupiravir, an Investigational Treatment for COVID-19 [PDF]

, 2020
Molnupiravir (MK-4482) is an investigational direct-acting antiviral agent that is under development for the treatment of COVID-19. Given the potential high demand for this compound, it was critical to develop a sustainable and efficient synthesis from ...
Tetsuji, Itoh, Jongrock, Kong, Hsing-I, Ho, Kevin, Maloney, John, McIntosh, Neil, Strotman, Peter, Maligres, Hao, Yang, Mark, Huffman, Jessica, Hurtak, Anders, Knight, William, Morris, Grant, Murphy, Patrick, Fier, Steven, Silverman, Deeptak, Verma, Weilan, Pan, Jonathan, Vroom, Tamas, Benkovics   +18 more
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The Fitness of Molnupiravir-Signed SARS-CoV-2 Variants: Imputation Analysis Based on Prescription Counts and Global Initiative on Sharing All Influenza Data Analyses by Country

Intervirology
Introduction: Molnupiravir is one of the oral direct-acting antivirals against SARS-CoV-2, largely deployed during the COVID-19 pandemic since the 2022 Omicron wave. While efficacy has been questioned in post-marketing clinical trials (leading
Daniele Focosi, Dave McNally, Fabrizio Maggi   +2 more
doaj   +1 more source

Fullerene Derivatives for Drug Delivery against COVID-19: A Molecular Dynamics Investigation of Dendro[60]fullerene as Nanocarrier of Molnupiravir

Nanomaterials, 2022
In this paper, a theoretical investigation is made regarding the possibility of using a water-soluble derivative of C60 as a drug delivery agent for treating Coronavirus disease 2019 (COVID-19).
Georgios I. Giannopoulos
doaj   +1 more source

Critical role of vaccination in preventing severe coronavirus disease 2019: perspectives from clinical outcomes in an Australian kidney transplant recipient cohort

Internal Medicine Journal, EarlyView.
Abstract Background Kidney transplant recipients (KTRs) disproportionately experience severe COVID‐19 infections. We previously identified concern regarding vaccine‐induced rejection as a barrier to vaccine uptake. Aim This study assesses COVID‐19 vaccine uptake, infection outcomes and allograft rejection in KTRs during the delta and omicron waves (BA ...
Dhakshayini Tharmaraj, Paayal Naidu, Mohana Baptista, Sarah McBride, Rhonda Stuart, Claire Dendle, Kevan R. Polkinghorne, William R. Mulley   +7 more
wiley   +1 more source

Molnupiravir. Hmong

, 2021
Title from PDF caption (viewed on January 4, 2022)."OHA4029A12292021 HMONG"--Running footer.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program.

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Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis [PDF]

, 2021
Molnupiravir is an orally available antiviral drug candidate currently in phase III trials for the treatment of patients with COVID-19. Molnupiravir increases the frequency of viral RNA mutations and impairs SARS-CoV-2 replication in animal models and in
Kokic, G., Cramer, P., Kabinger, F., Stiller, C., Cramer, Patrick, Schmitzová, Jana, Hillen, Hauke S., Dienemann, C., Stiller, Carina, Hillen, H., Schmitzova, J., Kokic, Goran, Dienemann, Christian, Kabinger, Florian, Höbartner, Claudia, Höbartner, C.   +15 more
core   +1 more source

Hitting Coronaviruses Where It Hurts: Antiviral Strategies Targeting Viral Proteins

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Viral proteins represent key vulnerabilities in human coronaviruses (HCoVs). This review outlines inhibitors targeting spike (S), main protease (Mpro), papain‐like protease (PLpro), and RNA‐dependent RNA polymerase (RdRp), mapping chemically diverse strategies that disrupt entry and replication, and provides an integrated view of current candidates ...
Álvaro de la Cruz‐Potenciano, Miguel Maldonado, María‐José Camarasa, Sonia de Castro   +3 more
wiley   +1 more source