Results 21 to 30 of about 65,278 (164)

Monkey Malaria in a European Traveler Returning from Malaysia

Emerging Infectious Diseases, 2008
In 2007, a Finnish traveler was infected in Peninsular Malaysia with Plasmodium knowlesi, a parasite that usually causes malaria in monkeys. P. knowlesi has established itself as the fifth Plasmodium species that can cause human malaria.
Anu Kantele, Hanspeter Marti, Ingrid Felger, Dania Müller, T. Sakari Jokiranta   +4 more
doaj   +1 more source

Non-viral generation of marmoset monkey iPS cells by a six-factor-in-one-vector approach. [PDF]

PLoS ONE, 2015
Groundbreaking studies showed that differentiated somatic cells of mouse and human origin could be reverted to a stable pluripotent state by the ectopic expression of only four proteins.
Katharina Debowski, Rita Warthemann, Jana Lentes, Gabriela Salinas-Riester, Ralf Dressel, Daniel Langenstroth, Jörg Gromoll, Erika Sasaki, Rüdiger Behr   +8 more
doaj   +1 more source

Molecular Cloning of Monkey Histamine H4 Receptor

Journal of Pharmacological Sciences, 2005
Histamine H4 receptor is considered as a novel therapeutic target for allergic diseases. To enhance the knowledge about species difference, which is essential for drug discovery research, monkey H4 receptor was identified.
Tamaki Oda, Shun-ichiro Matsumoto, Mitsuyuki Matsumoto, Jun Takasaki, Masazumi Kamohara, Takatoshi Soga, Hideki Hiyama, Masato Kobori, Masao Katoh   +8 more
doaj   +1 more source

Identification and characterization of a MAPT-targeting locked nucleic acid antisense oligonucleotide therapeutic for tauopathies

Molecular Therapy: Nucleic Acids, 2022
Tau is a microtubule-associated protein (MAPT, tau) implicated in the pathogenesis of tauopathies, a spectrum of neurodegenerative disorders characterized by accumulation of hyperphosphorylated, aggregated tau.
Amy Easton, Marianne L. Jensen, Congwei Wang, Peter H. Hagedorn, Yuwen Li, Michael Weed, Jere E. Meredith, Valerie Guss, Kelli Jones, Martin Gill, Carol Krause, Jeffrey M. Brown, Lisa Hunihan, Joanne Natale, Alda Fernandes, Yifeng Lu, Joe Polino, Mark Bookbinder, Greg Cadelina, Yulia Benitex, Ramola Sane, John Morrison, Dieter Drexler, Stephen E. Mercer, Charlotte Bon, Nikhil J. Pandya, Ravi Jagasia, Tai-Hsien Ou Yang, Tania Distler, Fiona Grüninger, Michael Meldgaard, Marco Terrigno, John E. Macor, Charles F. Albright, James Loy, Anja M. Hoeg, Richard E. Olson, Angela M. Cacace   +37 more
doaj   +1 more source

Characterization, isolation, and culture of spermatogonial stem cells in Macaca fascicularis

Asian Journal of Andrology, 2021
Spermatogonial stem cells (SSCs) have great applications in both reproductive and regenerative medicine. Primates including monkeys are very similar to humans with regard to physiology and pathology. Nevertheless, little is known about the isolation, the
Guo-Ping Mao, Ming-Hui Niu, Ying-Hong Cui, Rui-Ling Tang, Wei Chen, Bang Liu, Zuping He   +6 more
doaj   +1 more source

Mass spectrometry-based identification and whole-genome characterisation of the first pteropine orthoreovirus isolated from monkey faeces in Thailand

BMC Microbiology, 2018
Background The pteropine orthoreovirus (PRV) was isolated from monkey (Macaca fascicularis) faecal samples collected from human-inhabited areas in Lopburi Province, Thailand. These samples were initially obtained to survey for the presence of hepatitis E
Nathamon Kosoltanapiwat, Onrapak Reamtong, Tamaki Okabayashi, Sumate Ampawong, Amporn Rungruengkitkun, Tipparat Thiangtrongjit, Narin Thippornchai, Pornsawan Leaungwutiwong, Aongart Mahittikorn, Hirotake Mori, Thanada Yoohanngoa, Prechaya Yamwong   +11 more
doaj   +1 more source

Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys

Signal Transduction and Targeted Therapy, 2023
Tauopathy, characterized by the hyperphosphorylation and accumulation of the microtubule-associated protein tau, and the accumulation of Aβ oligomers, constitute the major pathological hallmarks of Alzheimer’s disease.
Zhuchi Tu, Sen Yan, Bofeng Han, Caijuan Li, Weien Liang, Yingqi Lin, Yongyan Ding, Huiyi Wei, Lu Wang, Hao Xu, Jianmeng Ye, Bang Li, Shihua Li, Xiao-Jiang Li   +13 more
doaj   +1 more source

[11C]CHIBA-1001 as a novel PET ligand for alpha7 nicotinic receptors in the brain: a PET study in conscious monkeys. [PDF]

PLoS ONE, 2008
BackgroundThe alpha7 nicotinic acetylcholine receptors (nAChRs) play an important role in the pathophysiology of neuropsychiatric diseases such as schizophrenia and Alzheimer's disease.
Kenji Hashimoto, Shingo Nishiyama, Hiroyuki Ohba, Masaaki Matsuo, Tatsuhiko Kobashi, Makoto Takahagi, Masaomi Iyo, Takeru Kitashoji, Hideo Tsukada   +8 more
doaj   +1 more source

Multiplex precise base editing in cynomolgus monkeys

Nature Communications, 2020
Due to the polygenic nature of most diseases, simultaneous correction or introduction of single nucleotide variants is needed. Here, the authors demonstrated the feasibility of multiplex base editing for polygenes disease modeling in cynomolgus monkey ...
Wenhui Zhang, Tomomi Aida, Ricardo C. H. del Rosario, Jonathan J. Wilde, Chenhui Ding, Xiaohui Zhang, Zulqurain Baloch, Yan Huang, Yu Tang, Duanduan Li, Hongyu Lu, Yang Zhou, Minqing Jiang, Dongdong Xu, Zhihao Fang, Zhanhong Zheng, Qunshan Huang, Guoping Feng, Shihua Yang   +18 more
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Generation of a Hutchinson–Gilford progeria syndrome monkey model by base editing

Protein & Cell, 2020
Many human genetic diseases, including Hutchinson-Gilford progeria syndrome (HGPS), are caused by single point mutations. HGPS is a rare disorder that causes premature aging and is usually caused by a de novo point mutation in the LMNA gene. Base editors
Fang Wang, Weiqi Zhang, Qiaoyan Yang, Yu Kang, Yanling Fan, Jingkuan Wei, Zunpeng Liu, Shaoxing Dai, Hao Li, Zifan Li, Lizhu Xu, Chu Chu, Jing Qu, Chenyang Si, Weizhi Ji, Guang-Hui Liu, Chengzu Long, Yuyu Niu   +17 more
doaj   +1 more source