Results 91 to 100 of about 125,969 (167)

Paradoxical effects of JZL184, an inhibitor of monoacylglycerol lipase, on bone remodelling in healthy and cancer-bearing mice

EBioMedicine, 2019
Background Cancer-associated bone disease is a serious complication in bone sarcomas and metastatic carcinomas of breast and prostate origin. Monoacylglycerol lipase (MAGL) is an enzyme of the endocannabinoid system, and is responsible for the ...
S. Marino, Daniëlle de Ridder, R. Bishop, N. Renema, M. Ponzetti, A. Sophocleous, M. Capulli, Abdullah Aljeffery, Giovana Carrasco, Marianela Dalghi Gens, A. Khogeer, S. Ralston, J. Gertsch, F. Lamoureux, D. Heymann, N. Rucci, A. Idris   +16 more
semanticscholar   +1 more source

A Thermostable Monoacylglycerol Lipase from Marine Geobacillus sp. 12AMOR1: Biochemical Characterization and Mutagenesis Study

International Journal of Molecular Sciences, 2019
Lipases with unique substrate specificity are highly desired in biotechnological applications. In this study, a putative marine Geobacillus sp. monoacylglycerol lipase (GMGL) encoded gene was identified by a genomic mining strategy.
Wei Tang, Dongming Lan, Zexin Zhao, Shuang Li, Xiuting Li, Yonghua Wang   +5 more
semanticscholar   +1 more source

Monoacylglycerol Lipase Modulators for Treating Autism Spectrum Disorders. [PDF]

ACS Med Chem Lett, 2023
Sabnis RW, Sabnis AR.
europepmc   +1 more source

Design, synthesis and biological evaluation of heterocyclic derivatives as potential MAGL inhibitors. [PDF]

, 2012
Facoltà di Farmacia Corso di laurea in Chimica e tecnologia farmaceutica; Relatore: prof.ssa C.Manera, dott.ssa F.Castelli; SSD: CHIM 08 Candidato: Gianfilippo Martello Titolo tesi: Design, synthesis and biological evaluation of heterocyclic derivatives ...
MARTELLO, GIANFILIPPO
core  

Monoacylglycerol lipase (MAGL) inhibitors based on a diphenylsulfide-benzoylpiperidine scaffold.

European journal of medicinal chemistry, 2021
Giulia Bononi, Giacomo Tonarini, G. Poli, Ivana Barravecchia, I. Caligiuri, M. Macchia, F. Rizzolio, G. Demontis, F. Minutolo, C. Granchi, T. Tuccinardi   +10 more
semanticscholar   +1 more source

Metabolic importance of adipose tissue monoacylglycerol acyltransferase 1 in mice and humans [PDF]

, 2018
Finck, Brian N., Franczyk, Michael, H. Liss, Kim H., Hall, Angela M., Klein, Samuel, Lutkewitte, Andrew J., Pietka, Terri, Yoshino, Jun   +7 more
core   +2 more sources

Cetirizine and Levetiracetam as Inhibitors of Monoacylglycerol Lipase: Investigating Their Repurposing Potential as Novel Osteoarthritic Pain Therapies. [PDF]

Pharmaceuticals (Basel), 2023
Andrei C, Mihai DP, Nitulescu G, Ungurianu A, Margina DM, Nitulescu GM, Olaru OT, Busca RM, Zanfirescu A.   +8 more
europepmc   +1 more source

Sexually dimorphic effects of monoacylglycerol lipase inhibitor MJN110 on stress-related behaviour and drinking in Marchigian Sardinian alcohol-preferring rats. [PDF]

Br J Pharmacol, 2023
Vozella V, Cruz B, Feldman HC, Bullard R, Bianchi PC, Natividad LA, Cravatt BF, Zorrilla EP, Ciccocioppo R, Roberto M.   +9 more
europepmc   +1 more source

Monoacylglycerol lipase regulates macrophage polarization and cancer progression in uveal melanoma and pan-cancer. [PDF]

Front Immunol, 2023
Tan Y, Pan J, Deng Z, Chen T, Xia J, Liu Z, Zou C, Qin B.   +7 more
europepmc   +1 more source

Monoacylglycerol Lipase Protects the Presynaptic Cannabinoid 1 Receptor from Desensitization by Endocannabinoids after Persistent Inflammation. [PDF]

J Neurosci, 2023
Bouchet CA, McPherson KB, Coutens B, Janowsky A, Ingram SL.   +4 more
europepmc   +1 more source