Results 111 to 120 of about 11,083 (203)

A novel method for measuring human hepatic lipase activity in postheparin plasma

Journal of Lipid Research, 2007
The objective of this study was to establish a hepatic lipase (HL) assay method that can be applied to automatic clinical analyzers. Seventy-four hyperlipidemic subjects (men/women 45/29) were recruited. Lipase activity was assayed measuring the increase
S. Imamura, J. Kobayashi, S. Sakasegawa, A. Nohara, K. Nakajima, M. Kawashiri, A. Inazu, M. Yamagishi, J. Koizumi, H. Mabuchi   +9 more
doaj   +1 more source

A first attempt into the production of acylglycerol mixtures from Echium oil

Frontiers in Bioengineering and Biotechnology, 2016
Enzymatic glycerolysis of Echium oil (Echium plantagineum) has been carried out in the presence of four commercial lipases. Different pretreatment of the reaction mixture, such as high pressure homogenization and addition of food grade monoolein as an ...
Luis eVázquez, Alejandro eJordán, Guillermo eReglero, Guillermo eReglero, Carlos F Torres   +4 more
doaj   +1 more source

Design, Synthesis, and Evaluation of 18F‑Labeled Monoacylglycerol Lipase Inhibitors as Novel Positron Emission Tomography Probes

, 2019
Dysfunction of monoacylglycerol lipase (MAGL) is associated with several psychopathological disorders, including drug addiction and neurodegenerative diseases.
Wakana, Mori, Kuan, Hu, 999449, Fujinaga, Masayuki, Zhang, Genwei, Hatori, Akiko, Hu, Kuan, Zhang, Ming-Rong, Chen, Zhen, Akiko, Hatori, 999432, 999433, 999436, 999437, 999434, 999435, 999438, Ming-Rong, Zhang, 999439, Zhang, Yiding, Masayuki, Fujinaga, 999440, Mori, Wakana, 999443, 999444, 999441, Shao, Tuo, 999442, 999447, 999448, Fu, Hualong, 999445, A. Schafroth, Michael, S. Van, Richard, 999446   +34 more
core   +1 more source

Development of a highly-specific 18F-labeled irreversible positron emission tomography tracer for monoacylglycerol lipase mapping

, 2020
Monoacylglycerol lipase (MAGL) is a serine hydrolase, which metabolizes 2-arachidonoylglycerol (2-AG) to arachidonic acid (AA) in the central nervous system (CNS).
1027107, Kuan, Hu, Wakana, Mori, 1027108, 1027109, Fujinaga, Masayuki, 1027103, 1027104, Rong, Jian, 1027105, 1027106, Yamasaki, Tomoteru, Zhang, Ming-Rong, Chen, Zhen, Akiko, Hatori, 1027100, 1027101, 1027102, Zhang, Yiding, Masayuki, Fujinaga, Hiraishi, Atsuto, Mori, Wakana, 1027110, 1027111, Sun, Jiyun, 1027112, Shao, Tuo, Liang, Huan, 1027113, S. Van, Richard, Chen, Jiahui, Yu, Qingzhen, L. Collier, Thomas, Hatori, Akiko, 1027083, 1027088, Tomoteru, Yamasaki, 1027089, Josephson, Lee, 1027084, 1027085, 1027086, 1027087, Ming-Rong, Zhang, 1027091, 1027092, 1027093, 1027094, Ogasawara, Daisuke, 1027090, 1027099, F. Cravatt, Benjamin, 1027095, 1027096, Atsuto, Hiraishi, 1027097, A. Schafroth, Michael, 1027098, Shao, Yihan   +58 more
core   +1 more source

Monoacylglycerol lipase promotes progression of hepatocellular carcinoma via NF-κB-mediated epithelial-mesenchymal transition

Journal of Hematology & Oncology, 2016
Background Monoacylglycerol lipase (MAGL), a critical lipolytic enzyme, has emerged as a key regulator of tumor progression, yet its biological function and clinical significance in hepatocellular carcinoma (HCC) is still unknown.
Weiping Zhu, Yiming Zhao, Jiamin Zhou, Xin Wang, Qi Pan, Ning Zhang, Longrong Wang, Miao Wang, Dihua Zhan, Zeyang Liu, Xigan He, Dening Ma, Shuang Liu, Lu Wang   +13 more
doaj   +1 more source

Monoacylglycerol lipase inhibition attenuates acute and anticipatory nausea in rats

, 2014
This study investigates the role of the endocannabinoid 2-arachidonyl glycerol (2-AG) in regulating acute and anticipatory nausea in rats using the conditioned gaping model.
Limebeer, Cheryl L., Morris, Heather I., Downey, Rachel I., Parker, Linda A.   +3 more
core  

Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels.

, 2008
The structure-activity relationships of organophosphorus (OP) and organosulfur compounds were examined in vitro and in vivo as inhibitors of mouse brain monoacylglycerol lipase (MAGL) hydrolysis of 2-arachidonoylglycerol (2-AG) and agonist binding at the
Ward, Anna M, Hudak, Carolyn S.S., Issa, Roger S., Casida, John E, Hudak, Carolyn S S, Burston, James J., Nomura, Daniel K., Abood, Mary E., Lichtman, Aron H, Wiley, Jenny L., Nomura, Daniel K, Issa, Roger S, Abood, Mary E, Wiley, Jenny L, Lichtman, Aron H., Fisher, Karl J, Ward, Anna M., Fisher, Karl J., Casida, John E., Burston, James J   +19 more
core   +1 more source

Lipases are differentially regulated by hormones to maintain free fatty acid homeostasis for insect brain development

BMC Biology
Background Free fatty acids (FFAs) play vital roles as energy sources and substrates in organisms; however, the molecular mechanism regulating the homeostasis of FFA levels in various circumstances, such as feeding and nonfeeding stages, is not fully ...
Yan-Xue Li, Qiao Yan, Tian-Wen Liu, Jin-Xing Wang, Xiao-Fan Zhao   +4 more
doaj   +1 more source

The monoacylglycerol lipase inhibitor JZL184 produces TRPV1-mediated antinociception.

, 2013
Intraplantar injection of formalin (2.5%) into the mouse paw produced a biphasic nociceptive response. (A) Intracerebroventricular (i.c.v.) injection of the monoacylglycerol lipase inhibitor JZL184 (10 nmol) 10 min before formalin injection produced ...
Peter M. Zygmunt (241661), Anna Ermund (241659), Bryndis Birnir (113570), Alain Eschalier (209750), Stuart Bevan (303154), Bo A. G. Jönsson (241660), Edward D. Högestätt (241662), Charlotte Simonsen (441655), Pouya Movahed (491625), Christophe Mallet (241657), David A. Andersson (303152), Ana Gomis (491626), Anders Blomgren (441654)   +12 more
core   +1 more source

The activity and properties of an acidic triacylglycerol lipase from adult and fetal rat lung [PDF]

, 1986
Triacylglycerol lipase with maximal activity at pH 5 was present in adult and fetal lung. The activity was inhibited by serum concentrations used to measure lipoprotein lipase and by 0.5 M NaCl.
Brooks, Bob, Weinhold, Paul A.
core   +1 more source