Results 131 to 140 of about 11,083 (203)

RNA interference suggests a primary role for monoacylglycerol lipase in degradation of the endocannabinoid 2-arachidonoylglycerol.

, 2004
The endogenous cannabinoid, 2-arachidonoylglycerol (2-AG), is produced by neurons and other cells in a stimulus-dependent manner and undergoes rapid biological inactivation through transport into cells and catalytic hydrolysis.
Thien P Dinh, Satish Kathuria, Daniele Piomelli   +2 more
core  

Cetirizine and Levetiracetam as Inhibitors of Monoacylglycerol Lipase: Investigating Their Repurposing Potential as Novel Osteoarthritic Pain Therapies. [PDF]

Pharmaceuticals (Basel), 2023
Andrei C, Mihai DP, Nitulescu G, Ungurianu A, Margina DM, Nitulescu GM, Olaru OT, Busca RM, Zanfirescu A.   +8 more
europepmc   +1 more source

The complete digestion of human milk triacylglycerol in vitro requires gastric lipase, pancreatic colipase-dependent lipase, and bile salt-stimulated lipase.

, 1990
Gastric lipase, pancreatic colipase-dependent lipase, and bile salt-stimulated lipase all have potential roles in digestion of human milk triacylglycerol.
S Bernbäck, L Bläckberg, Bernbäck, S, Hernell, Olle,, Bläckberg, Lars, O Hernell   +5 more
core   +1 more source

Monoacylglycerol Lipase ABHD12 [PDF]

, 2020
openaire   +1 more source

A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence. [PDF]

Nat Commun, 2023
Jiang M, Huizenga MCW, Wirt JL, Paloczi J, Amedi A, van den Berg RJBHN, Benz J, Collin L, Deng H, Di X, Driever WF, Florea BI, Grether U, Janssen APA, Hankemeier T, Heitman LH, Lam TW, Mohr F, Pavlovic A, Ruf I, van den Hurk H, Stevens AF, van der Vliet D, van der Wel T, Wittwer MB, van Boeckel CAA, Pacher P, Hohmann AG, van der Stelt M.   +28 more
europepmc   +1 more source

Monoacylglycerol lipase (MAGL) [PDF]

Science-Business eXchange, 2012
openaire   +1 more source

Novel Substituted Spiro-Ureas as Monoacylglycerol Lipase Inhibitors

ACS Medicinal Chemistry Letters
This patent describes novel spiro-ureas as a novel class of monoacylglycerol lipase (MAGL) inhibitors. It provides details on the novel substituted spiro-ureas, pharmaceutical composition, and therapeutic applications for diseases associated with MAGL dysregulation.
Jian Rong, Steven H. Liang
openaire   +2 more sources

Endocannabinoid enzymes monoacylglycerol lipase and diacylglycerol lipase [PDF]

, 2021
openaire   +1 more source

Sexually dimorphic effects of monoacylglycerol lipase inhibitor MJN110 on stress-related behaviour and drinking in Marchigian Sardinian alcohol-preferring rats. [PDF]

Br J Pharmacol, 2023
Vozella V, Cruz B, Feldman HC, Bullard R, Bianchi PC, Natividad LA, Cravatt BF, Zorrilla EP, Ciccocioppo R, Roberto M.   +9 more
europepmc   +1 more source

Monoacylglycerol lipase regulates macrophage polarization and cancer progression in uveal melanoma and pan-cancer. [PDF]

Front Immunol, 2023
Tan Y, Pan J, Deng Z, Chen T, Xia J, Liu Z, Zou C, Qin B.   +7 more
europepmc   +1 more source