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Monoacylglycerol lipase (MAGL) as a promising therapeutic target.
Biochemical Pharmacology, 2018Monoacylglycerol lipase (MAGL) has been characterized as the main enzyme responsible for the inactivation of the most abundant brain endocannabinoid, 2-arachidonoylglycerol (2-AG).
Ana Gil-Ordóñez +3 more
semanticscholar +3 more sources
International Journal of Biological Macromolecules, 2023
Monoacylglycerol lipase (MAGL) involved in regulating plant growth and development and stress responses, hydrolyzes monoacylglycerol (MAG) into free fatty acid and glycerol, which is the last step of triacylglycerol (TAG) breakdown.
Yi-hua Zhan +7 more
semanticscholar +1 more source
Monoacylglycerol lipase (MAGL) involved in regulating plant growth and development and stress responses, hydrolyzes monoacylglycerol (MAG) into free fatty acid and glycerol, which is the last step of triacylglycerol (TAG) breakdown.
Yi-hua Zhan +7 more
semanticscholar +1 more source
Journal of Medicinal Chemistry, 2022
Monoacylglycerol lipase (MAGL) is one of the key enzymes in the endocannabinoid system. Inhibition of MAGL has been proposed as an attractive approach for the treatment of various diseases.
Yingfang He +13 more
semanticscholar +1 more source
Monoacylglycerol lipase (MAGL) is one of the key enzymes in the endocannabinoid system. Inhibition of MAGL has been proposed as an attractive approach for the treatment of various diseases.
Yingfang He +13 more
semanticscholar +1 more source
Food Chemistry, 2022
Enzymatic degumming is an essential refining process to improve oil quality. In this study, a monoacylglycerol lipase GMGL was derived from marine Geobacillus sp., and was found that not only took monoacylglycerol (MAG) as substrate, but also had ...
Xuan Liu +6 more
semanticscholar +1 more source
Enzymatic degumming is an essential refining process to improve oil quality. In this study, a monoacylglycerol lipase GMGL was derived from marine Geobacillus sp., and was found that not only took monoacylglycerol (MAG) as substrate, but also had ...
Xuan Liu +6 more
semanticscholar +1 more source
ChemMedChem, 2021
Recently fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) inhibitors have been in the limelight due to their anticancer potential. Both FAAH and MAGL are the endocannabinoid degrading enzymes that hydrolyze several endogenous ligands,
Shivani Jaiswal, S. R. Ayyannan
semanticscholar +1 more source
Recently fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) inhibitors have been in the limelight due to their anticancer potential. Both FAAH and MAGL are the endocannabinoid degrading enzymes that hydrolyze several endogenous ligands,
Shivani Jaiswal, S. R. Ayyannan
semanticscholar +1 more source
Current Drug Research Reviews, 2022
Monoacylglycerol is a metabolic key serine hydrolase, engaged in the regulation of signalling network system of endocannabinoids, which is associated with various physiological processes like pain, inflammation, feeding cognition and neurodegenerative ...
Abhishek S. Kashyap +2 more
semanticscholar +1 more source
Monoacylglycerol is a metabolic key serine hydrolase, engaged in the regulation of signalling network system of endocannabinoids, which is associated with various physiological processes like pain, inflammation, feeding cognition and neurodegenerative ...
Abhishek S. Kashyap +2 more
semanticscholar +1 more source
Analytical Chemistry, 2023
The fast and selective separation method of intact monoacylglycerol (MG) and diacylglycerol (DG) isomers using chiral supercritical fluid chromatography-mass spectrometry (SFC-MS) was developed and employed to study lipase selectivity in the hydrolysis ...
O. Kozlov +6 more
semanticscholar +1 more source
The fast and selective separation method of intact monoacylglycerol (MG) and diacylglycerol (DG) isomers using chiral supercritical fluid chromatography-mass spectrometry (SFC-MS) was developed and employed to study lipase selectivity in the hydrolysis ...
O. Kozlov +6 more
semanticscholar +1 more source
Bioorganic & Medicinal Chemistry Letters, 2021
Monoacylglycerol lipase (MAGL) is the major enzyme that catalyzes the hydrolysis of monoacylglycerols (MAGs). MAGL is responsible for degrading 2-arachidonoylglycerol (2-AG) to arachidonic acid (AA) and glycerol in the brain and specific tissues.
Fengmin Xiong +7 more
semanticscholar +1 more source
Monoacylglycerol lipase (MAGL) is the major enzyme that catalyzes the hydrolysis of monoacylglycerols (MAGs). MAGL is responsible for degrading 2-arachidonoylglycerol (2-AG) to arachidonic acid (AA) and glycerol in the brain and specific tissues.
Fengmin Xiong +7 more
semanticscholar +1 more source
The journal of obstetrics and gynaecology research, 2021
Cervical cancer is one of common diseases among women. There are limited therapies for patients with metastatic or recurrent cervical cancer. This study sought to explore the role of monoacylglycerol lipase (MAGL), an important metabolic enzyme, in ...
Chao Wang +3 more
semanticscholar +1 more source
Cervical cancer is one of common diseases among women. There are limited therapies for patients with metastatic or recurrent cervical cancer. This study sought to explore the role of monoacylglycerol lipase (MAGL), an important metabolic enzyme, in ...
Chao Wang +3 more
semanticscholar +1 more source
An updated patent review of monoacylglycerol lipase (MAGL) inhibitors (2018-present)
Expert Opinion on Therapeutic Patents, 2020Introduction Monoacylglycerol lipase (MAGL) belongs to the endocannabinoid system and is responsible for the inactivation of endocannabinoid 2-arachidonoylglycerol.
Giulia Bononi +6 more
semanticscholar +1 more source