Results 81 to 90 of about 11,083 (203)

Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes

British Journal of Pharmacology, EarlyView.
Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley   +1 more source

Assessment of a Spectrophotometric Assay for Monoacylglycerol Lipase Activity

The AAPS Journal, 2010
Endocannabinoids are lipid-signaling molecules that bind cannabinoid receptors. These G-protein-coupled receptors were discovered as binding sites for Δ9-tetrahydrocannabinol (THC), the psychoactive component of marijuana (Cannabis sativa) (1). Two types of cannabinoid receptors are known: cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2 ...
Nadine M, Ulloa, Dale G, Deutsch
openaire   +3 more sources

Monoacylglycerol Lipase Inhibitor MJN110 Reduces Neuronal Hyperexcitability, Restores Dendritic Arborization Complexity, and Regulates Reward-Related Behavior in Presence of HIV-1 Tat

Frontiers in Neurology, 2021
While current therapeutic strategies for people living with human immunodeficiency virus type 1 (HIV-1) suppress virus replication peripherally, viral proteins such as transactivator of transcription (Tat) enter the central nervous system early upon ...
Alexis F. League, Benjamin L. Gorman, Douglas J. Hermes, Clare T. Johnson, Ian R. Jacobs, Barkha J. Yadav-Samudrala, Justin L. Poklis, Micah J. Niphakis, Benjamin F. Cravatt, Aron H. Lichtman, Bogna M. Ignatowska-Jankowska, Sylvia Fitting   +11 more
doaj   +1 more source

Glicerólise enzimática de óleos vegetais assistida por ultrassom em meio livre de solvente orgânico sob agitação [PDF]

, 2013
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia de Alimentos, Florianópolis, 2013.Este trabalho apresenta dados experimentais referentes à glicerólise de óleo de soja e óleo de ...
Remonatto, Daniela
core  

The relationship between the carboxylesterase and monoacylglycerol lipase activities of chicken liver microsomes

, 1985
The carboxylesterase (carboxylic-ester hydrolase, EC 3.1.1.1) and monoacylglycerol lipase (glycerol-monoester acylhydrolase, EC 3.1.1.23) activities, measured against ethyl butyrate and emulsified monooleoylglycerol respectively, were determined for ...
de Jersey J., Zerner B., Keough D.T.
core   +1 more source

Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors. [PDF]

, 2021
An interesting enzyme of the endocannabinoid system is monoacylglycerol lipase (MAGL). This enzyme, which metabolizes the endocannabinoid 2-arachidonoylglycerol (2-AG), has attracted great interest due to its involvement in several physiological and ...
Tiziana Perin, Rizzolio F., Sandra Glasmacher, Gertsch, Jürg, Tuccinardi T., Poli, Giulio, Elisa Giovannetti, Filippo Minutolo, Giovannetti, Elisa, Macchia, Marco, Carlotta Granchi, Flavio Rizzolio, Bononi, Giulia, Gori, Eleonora, Gori E., Stefano Palazzolo, Canzonieri V., Isabella Caligiuri, Rebecca Ferrisi, Rizzolio, Flavio, Glasmacher S., Andrea Chicca, Perin, Tiziana, Gertsch J., Macchia M., Palazzolo, Stefano, Bononi G., Palazzolo S., Granchi, Carlotta, Marco Macchia, Sodi, Andrea, Minutolo, Filippo, Sodi A., JÃrg Gertsch, Caligiuri I., Eleonora Gori, Giulio Poli, Granchi C., Gertsch, J. rg, Giulia Mantini, Glasmacher, Sandra, Vincenzo Canzonieri, Chicca, Andrea, Giovannetti E., Canzonieri, Vincenzo, Ferrisi, Rebecca, Mantini, Giulia, Andrea Sodi, Ferrisi R., Perin T., Chicca A., Poli G., Tuccinardi, Tiziano, Giulia Bononi, Mantini G., Caligiuri, Isabella, Minutolo F., Tiziano Tuccinardi   +57 more
core   +1 more source

The malate–aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes

The FEBS Journal, EarlyView.
Brown fat cells burn lipids within their mitochondria to generate heat. This process involves two energy “shuttles,” one of which is naturally blocked during heat production. We found that the second shuttle (MASh) is not required to generate heat. However, when MASh is disabled, the fatty acids meant for fuel are instead converted back into stored fat.
Michaela Veliova, Caroline M. Ferreira, Katrina P. Montales, Francisco Villalobos, Alexandra J. Brownstein, Rebeca Acín‐Pérez, Gabrielly S. Ferreira, Anthony E. Jones, Linsey Stiles, Ajit S. Divakaruni, Marc Liesa, Orian S. Shirihai, Marcus F. Oliveira   +12 more
wiley   +1 more source

Development of an HPLC/UV assay for the evaluation of inhibitors of human recombinant monoacylglycerol lipase [PDF]

, 2015
Monoacylglycerol lipase (MAGL) is a membrane-associated cytosolic serine hydrolase which catalyses the hydrolysis of the endocannabinoid 2-arachidonoylglycerol into arachidonic acid and glycerol.
MANERA, CLEMENTINA, Saccomanni, G, Macchia, M, TAMPUCCI, SILVIA, Gertsch, J., Chicca, Andrea, DEL CARLO, SARA, Tampucci, S, Burgalassi, S, Arena, C, Gertsch, Jürg, Del Carlo, S, SACCOMANNI, GIUSEPPE, Bertini, S, BURGALASSI, SUSI, Manera, C, ARENA, CHIARA, BERTINI, SIMONE, MACCHIA, MARCO   +18 more
core   +1 more source

Steroidogenic compensation and lipid deficiency with enhanced NAD+ salvage in small‐for‐gestational‐age placenta

The FEBS Journal, EarlyView.
Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo, Lorenza Driul, Vanessa Tolotto, Eros Di Giorgio, Luigi E. Xodo   +4 more
wiley   +1 more source

Intermittent hypoxia increases lipid insulin resistance in healthy humans: A randomized crossover trial

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
This scheme illustrates the main results of the present study showing an increase in circulating free fatty acids (FFA) that are likely to be related to several mechanisms like decrease in FFA insulin sensitivity and increase in FFA production. Significant changes are labelled in white, and non‐significant or hypothesis are labelled in pale green ...
Anne Briançon‐Marjollet, Marie Netchitaïlo, Fanny Fabre, Elise Belaidi, Claire Arnaud, Anne‐Laure Borel, Patrick Levy, Jean‐Louis Pépin, Renaud Tamisier   +8 more
wiley   +1 more source