Results 81 to 90 of about 68,881 (203)

Kinetic mechanism of enzymatic esterification and quantitative profiling of acylglycerol isomer distribution

Grain & Oil Science and Technology
Diacylglycerol (DAG) is a functional oil that can reduce body fat accumulation and postprandial triglycerides. In this study, lipase-catalyzed esterification of oleic acid with glycerol was investigated to elucidate the kinetics and selectivity of each ...
Shuo Zou, Hongzeng Ai, Yee-Ying Lee, Yong Wang, Zhen Zhang   +4 more
doaj   +1 more source

Tapetal Expression of BnaC.MAGL8.a Causes Male Sterility in Arabidopsis

Frontiers in Plant Science, 2019
Monoacylglycerol lipase (MAGL) hydrolyzes monoacylglycerol, producing free fatty acid and glycerol. Although this enzyme has been shown to play important roles in mammal, its potential function in plants remains poorly understood. In a survey of the MAGL
Jie Gao, Qun Li, Nan Wang, Baolong Tao, Jing Wen, Bin Yi, Chaozhi Ma, Jinxing Tu, Tingdong Fu, Qiang Li, Jitao Zou, Jinxiong Shen   +11 more
doaj   +1 more source

Intermittent hypoxia increases lipid insulin resistance in healthy humans: A randomized crossover trial

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
This scheme illustrates the main results of the present study showing an increase in circulating free fatty acids (FFA) that are likely to be related to several mechanisms like decrease in FFA insulin sensitivity and increase in FFA production. Significant changes are labelled in white, and non‐significant or hypothesis are labelled in pale green ...
Anne Briançon‐Marjollet, Marie Netchitaïlo, Fanny Fabre, Elise Belaidi, Claire Arnaud, Anne‐Laure Borel, Patrick Levy, Jean‐Louis Pépin, Renaud Tamisier   +8 more
wiley   +1 more source

Polar Lipid and Fatty Acid Profiles of Oat Groats Substantially Influenced by Field Management: A Comparison of Cultivars, Sowing Times and Fertilizer Composition

Plant, Cell &Environment, EarlyView.
ABSTRACT The polar lipids in oat grains are crucial due to their biological functions, nutritional quality, potential use in food flavour and processing, the protection they provide against biotic and abiotic stresses, and their ability to act as cellular signalling molecules.
Syed Rehmat Ullah Shah, Lena Engström, Carl Grey, Anders Jonsson, Johanna Wetterlind, Cecilia Tullberg   +5 more
wiley   +1 more source

Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor [PDF]

, 2019
Monoacylglycerol lipase (MAGL) is the enzyme degrading the endocannabinoid 2-arachidonoylglycerol, and it is involved in several physiological and pathological processes.
Carlotta Granchi (1375599), Granchi, Carlotta, El Boustani, Maguie, Cristina Licari (6319949), Margherita Lapillo (2931531), Tiziano Tuccinardi (409135), Minutolo, Filippo, Gertsch, Jürg, Giulio Poli (809754), Poli, Giulio, Sandra Glasmacher (6319943), Andrea Chicca (710770), Macchia, Marco, Glasmacher, Sandra, Chicca, Andrea, Lapillo, Margherita, Isabella Caligiuri (285374), Bononi, Giulia, Giulia Bononi (6319946), Marco Macchia (409137), Filippo Minutolo (1343184), Jürg Gertsch (1589107), Flavio Rizzolio (74629), Tuccinardi, Tiziano, Rizzolio, Flavio, Caligiuri, Isabella, Maguie el Boustani (6319952), Licari, Cristina   +27 more
core   +2 more sources

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone, Luciane H. Gargaglioni   +1 more
wiley   +1 more source

Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors [PDF]

, 2018
Monoacylglycerol lipase (MAGL) is the enzyme hydrolyzing the endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid and glycerol.
Carlson, Kathryn E., Giannotti, Massimiliano, Chicca, Andrea, Lapillo, Margherita, Granchi, Carlotta, Katzenellenbogen, John A., Carlson, Kathryn E, Minutolo, Filippo, Kim, Sung Hoon, Bononi, Giulia, Poli, Giulio, Martinelli, Adriano, Katzenellenbogen, John A, Tuccinardi, Tiziano, Nieri, Daniela, Rizzolio, Flavio, Caligiuri, Isabella, Macchia, Marco, Boustani, Maguie El, Fortunato, Serena   +19 more
core   +2 more sources

A novel method for measuring human lipoprotein lipase and hepatic lipase activities in postheparin plasma*

Journal of Lipid Research, 2008
The objective of this study was to establish a new lipoprotein lipase (LPL) and hepatic lipase (HL) activity assay method. Seventy normal volunteers were recruited.
S. Imamura, J. Kobayashi, K. Nakajima, S. Sakasegawa, A. Nohara, T. Noguchi, M.A. Kawashiri, A. Inazu, S.S. Deeb, H. Mabuchi, J.D. Brunzell   +10 more
doaj   +1 more source

Δ9 Tetrahydrocannabinol and cannabis extracts differentially improve adipoinsular dysfunction in diet‐induced obesity

The Journal of Physiology, EarlyView.
Abstract figure legend THC and extract administered to diet‐induced obese mice reduced body weight and fat storage. Extract, but not THC, improved glucose clearance by a mechanism that may include restoring adipoinsular function. Abstract Diet‐induced obesity (DIO) is associated with dysregulated adipoinsular axis and endocannabinoid system (eCBS ...
Bryant Avalos, Martin Olmos, Courtney P. Wood, Camila Alvarez, Haley M. Read, Parima Udompholkul, Theodore Garland Jr, Nicholas V. DiPatrizio   +7 more
wiley   +1 more source

Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors [PDF]

, 2018
Monoacylglycerol lipase (MAGL) is a serine hydrolase that plays an important role in the degradation of the endocannabinoid neurotransmitter 2-arachidonoylglycerol, which is implicated in many physiological processes.
De Stefano L., Manera, Clementina, Rizzolio F., Margherita Lapillo, Gertsch, Jürg, Tuccinardi T., Baraldi, Stefania, Martinelli, Adriano, Filippo Minutolo, Macchia, Marco, De Stefano, Lucia, Lorenzo Di Cesare Mannelli, Carlotta Granchi, Stefania Baraldi, Martinelli A., Flavio Rizzolio, Carla Ghelardini, Di Cesare Mannelli, Lorenzo, Di Cesare Mannelli L., Ruggiero, Emanuela, Rizzolio, Flavio, Andrea Chicca, Gertsch J., Macchia M., Mojgan Aghazadeh Tabrizi, Lapillo M., Baraldi S., Granchi, Carlotta, Marco Macchia, Baraldi, Pier Giovanni, Minutolo, Filippo, Clementina Manera, Granchi C., Ghelardini, C, Baraldi P. G., Jürg Gertsch, Aghazadeh Tabrizi M., Lucia De Stefano, Aghazadeh Tabrizi, Mojgan, Di Cesare Mannelli, L, Emanuela Ruggiero, Adriano Martinelli, Chicca, Andrea, Pier Giovanni Baraldi, Lapillo, Margherita, Manera C., Chicca A., Ghelardini C., Tuccinardi, Tiziano, Ghelardini, Carla, Ruggiero E., Tiziano Tuccinardi, Minutolo F.   +52 more
core   +2 more sources