Results 11 to 20 of about 5,459 (175)

Understanding the dynamic nature of plant lipid anabolic and catabolic metabolism is key to sustainable oilseed engineering. [PDF]

New Phytol
Summary Plant‐derived oils are essential sources of reduced carbon and various fatty acid (FA) structures for food, biofuels, and the oleochemical industry. Despite extensive efforts, engineering mainstream oilseed crops to produce high levels of industrially valuable unusual FAs (UFAs) remains challenging.
Parchuri P, McGuire ST, Garneau MG, Barroga NAM, Bates PD.   +4 more
europepmc   +2 more sources

Unraveling Endocannabinoid Signaling Pathways in Cisplatin-Induced Ototoxicity. [PDF]

FASEB J
We performed a comprehensive molecular profiling of the endocannabinoid (eCB) system (ECS) in an auditory Hair cell (HC)‐like cell line (1). Afterwards, we developed suitable in vitro and in vivo models of cisplatin‐induced ototoxicity where we identified distinct components of the ECS (CB2R, DAGLβ and ABHD6) as molecular targets of the drug (2 ...
Palaniappan S, Tisi A, Di Meo C, Urbano C, Fenton GE, Della Valle F, Fanti F, Compagnone D, Nazarè M, Versnel H, Aramini A, Allegretti M, Maccarrone M.   +12 more
europepmc   +2 more sources

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Therapeutic potential of monoacylglycerol lipase inhibitors [PDF]

Life Sciences, 2013
Marijuana and aspirin have been used for millennia to treat a wide range of maladies including pain and inflammation. Both cannabinoids, like marijuana, that exert anti-inflammatory action through stimulating cannabinoid receptors, and cyclooxygenase (COX) inhibitors, like aspirin, that suppress pro-inflammatory eicosanoid production have shown ...
Melinda M, Mulvihill, Daniel K, Nomura
openaire   +2 more sources

Assay of Monoacylglycerol Lipase Activity [PDF]

, 2016
Monoacylglycerol lipase (MGL) is a serine hydrolase involved in the biological deactivation of the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG). 2-AG is one of the main endogenous lipid agonists for cannabinoid receptors in the brain and elsewhere in the body.
Jung, Kwang-Mook, Piomelli, Daniele
openaire   +5 more sources

Inhibition of monoacylglycerol lipase reduces nicotine withdrawal [PDF]

British Journal of Pharmacology, 2015
Background and PurposeAbrupt discontinuation of nicotine, the main psychoactive component in tobacco, induces a withdrawal syndrome in nicotine‐dependent animals, consisting of somatic and affective signs, avoidance of which contributes to drug maintenance.
P P, Muldoon, J, Chen, J L, Harenza, R A, Abdullah, L J, Sim-Selley, B F, Cravatt, M F, Miles, X, Chen, A H, Lichtman, M I, Damaj   +9 more
openaire   +2 more sources

The evolution and comparative neurobiology of endocannabinoid signalling [PDF]

, 2012
CB(1)- and CB(2)-type cannabinoid receptors mediate effects of the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide in mammals. In canonical endocannabinoid-mediated synaptic plasticity, 2-AG is generated postsynaptically by diacylglycerol ...
Devane W. A., Maurice R. Elphick, Montell C., Soderstrom K., Soderstrom K.   +4 more
core   +1 more source

Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfinding [PDF]

, 2010
Peer reviewedPublisher ...
Barabas, Klaudia, Cameron, Gary, Harkany, Tibor, Keimpema, Erik, Mackie, Ken, Morozov, Yury M, Torii, Masaaki, Tortoriello, Giuseppe, Watanabe, Masahiko, Yanagawa, Yuchio   +9 more
core   +1 more source

Characteristics of a Monoacylglycerol Lipase Isolated from Pseudomonas sp. LP7315 -Hydrolysis and Synthesis of Monoglycerides [PDF]

, 2001
A monoacylglycerol lipase (MGL) was purified from Pseudomonas sp. LP7315 by ammonium sulfate precipitation, anion-exchange chromatography, and preparative electrophoresis.
Miyake, Akira, Nakanishi, Kazuhiro, Ozaki, Sho, Sakiyama, Takaharu, Tanaka, Atsushi, Umeoka, Midori, Yoshimi, Tsuyoshi   +6 more
core   +1 more source

Untargeted Lipidomic Analysis to Broadly Characterize the Effects of Pathogenic and Non-Pathogenic Staphylococci on Mammalian Lipids [PDF]

, 2018
Modification of the host lipidome via secreted enzymes is an integral, but often overlooked aspect of bacterial pathogenesis. In the current era of prevalent antibiotic resistance, knowledge regarding critical host pathogen lipid interactions has the ...
Baker, Paul RS, Contaifer, Daniel, Jr., Ekroos, Kim, Jefferson, Kimberly K., Kumar, Naren Gajenthra, Wijesinghe, Dayanjan S.   +5 more
core   +4 more sources