Results 91 to 100 of about 68,186 (189)
MedComm – Biomaterials and Applications, Volume 4, Issue 2, June 2025.IDD and OA is caused by various mechanisms, creating a vicious cycle that impairs disc function. Nanozymes and nano‐enzyme delivery systems offer innovative therapies by targeting these underlying mechanisms, such as anti‐inflammatory therapy, ECM repair, cellular dysfunction and antioxidant therapy, providing a promising approach to restoring tissue ...
Lei Peng +4 more
wiley +1 more source
Studies on Monoamine Oxidase (Report XXIV) Effect of Harmine on Monoamine Oxidase
Japanese Journal of Pharmacology, 1974 Abstract Using beef brain and liver mitochondria, the effects of several inhibitors on the oxidation of serotonin and tyramine were studied. Mitochondrial MAO of beef brain showed pH optima of 8.8 with serotonin and 8.0 with tyramine. Pheniprazine had similar effects on the oxidations of serotonin and tyramine by brain MAO at pH 7.4 and pH 8.5 ...
openaire +4 more sources
British Journal of Clinical Pharmacology, Volume 91, Issue 6, Page 1749-1759, June 2025.Abstract Aims Antidepressant use increases around long‐term care facility (LTCF) entry, and initiation during hospitalizations may contribute to this. This study characterized the care setting (i.e., community‐based, hospital or LTCF) where antidepressants were initiated and determined associated resident characteristics.
Georgina A. Hughes +6 more
wiley +1 more source
Vestibular modulation by stimulant derivatives in a pentameric ligand‐gated ion channel
British Journal of Pharmacology, Volume 182, Issue 12, Page 2790-2802, June 2025.Background and Purpose Allosteric modulation of pentameric ligand‐gated ion channels (pLGICs) are critical for the action of neurotransmitters and many psychoactive drugs. However, details of their modulatory mechanisms remain unclear, especially beyond the orthosteric neurotransmitter‐binding sites. The recently reported prokaryotic symbiont of Tevnia
Emelia Karlsson +8 more
wiley +1 more source
CNS Neuroscience &Therapeutics, Volume 31, Issue 6, June 2025.Compared with hormone or escitalopram alone, a combined therapy of Femoston with escitalopram may be more effective in the treatment of perimenopausal chronic insomnia. Serum levels of 5‐HT, E2, FSH, and LH may serve as objective indicators to assess the disease severity in perimenopausal women.
Hui Chen +8 more
wiley +1 more source
Clinical and Translational Science, Volume 18, Issue 6, June 2025.ABSTRACT Pharmacogenetics is a promising strategy to facilitate individualized care for patients with Major Depressive Disorder (MDD). Research is ongoing to identify the optimal genetic markers for predicting outcomes to antidepressant therapies. The primary aim of this systematic review was to summarize antidepressant pharmacogenetic studies to ...
Caroline W. Grant +10 more
wiley +1 more source
Journal of Neurochemistry, Volume 169, Issue 6, June 2025.A trace amine beta‐phenylethylamine is anxiolytic and reduces brain acetylcholine at 12 μg/L, but elevates anxiety and cortisol levels at 1000 μg/L. Acute tryptamine at 7 mg/L is anxiogenic, reduces shoaling and social interaction, but elevates brain acetylcholine and cortisol levels. Acute tyramine at 15 μg/L, and octopamine at 125, 500, and 1500 μg/L,
Thalia M. Quintanilha +10 more
wiley +1 more source
Journal of Oral Rehabilitation, Volume 52, Issue 6, Page 923-936, June 2025.ABSTRACT Background Chronic temporomandibular disorder (TMD) pain significantly impairs quality of life and lacks universally effective treatments. Antidepressants, traditionally used for mood disorders, have shown potential in managing chronic pain conditions.
Takara Dei +5 more
wiley +1 more source
Localisation of proline oxidase and Δ-pyrroline-5-carboxylic acid dehydrogenase in rat liver [PDF]
, 1969 Beisenherz +11 more
core +1 more source