Computer-aided approach for the identification of lead molecules as the inhibitors of cholinesterase’s and monoamine oxidases: Novel target for the treatment of Alzheimer disease [PDF]
Journal of the Serbian Chemical SocietyMolecular docking is a promising and reliable technology for the purpose of discovering lead compounds via virtual screening. In addition to allowing for the testing of a large number of compounds, it also allows for the determination of how the selected
Ejaz Syeda Abida +4 more
doaj +1 more source
Case Report: A possible novel adult-onset, progressive MAO-A hypofunction
Frontiers in NeuroscienceWe describe the clinical presentation, pathophysiology, and successful treatment of a previously undocumented adult onset, progressive form of monoamine oxidase A hypofunction.
Stefan Berteau, Erik Armitano
doaj +1 more source
Monoamine Oxidase and Behaviour
Annals of Medicine, 1995 Item does not contain ...
openaire +3 more sources
An amine oxidase gene from mud crab, Scylla paramamosain, regulates the neurotransmitters serotonin and dopamine in vitro. [PDF]
PLoS ONE, 2018 Amine oxidase, which participates in the metabolic processing of biogenic amines, is widely found in organisms, including higher organisms and various microorganisms.
Junguo Liu +8 more
doaj +1 more source
Synthesis of the flavocoenzyme of monoamine oxidase [PDF]
FEBS Letters, 1971 Reaction scheme is entirely in accord with our own conclusion that the go-substituent in the case of MAO-flavin must be a functional group devoid of acid-base properties, though capable of donating electrons to and accepting excitons from the flavin nucleus.
Ghisla, Sandro, Hemmerich, Peter
openaire +3 more sources
Parameters for Irreversible Inactivation of Monoamine Oxidase
Molecules, 2020 The irreversible inhibitors of monoamine oxidases (MAO) slow neurotransmitter metabolism in depression and neurodegenerative diseases. After oxidation by MAO, hydrazines, cyclopropylamines and propargylamines form a covalent adduct with the flavin ...
Rona R. Ramsay +8 more
doaj +1 more source
Questions in the Chemical Enzymology of MAO
Chemistry, 2021 We have structure, a wealth of kinetic data, thousands of chemical ligands and clinical information for the effects of a range of drugs on monoamine oxidase activity in vivo.
Rona R. Ramsay, Alen Albreht
doaj +1 more source
Platelet monoamine oxidase activity in diabetics.
Acta Médica Portuguesa, 1980 Platelet monoamine oxidase (MAO) activity was determined, using benzylamine as substract. Results are expressed as nM benzaldehyde/mg protein hour, at 37”. A total of 79 diabetics (40 M and 39 F) ranging in age from 3 to 70 years was studied.
Maria Azevedo +3 more
doaj +1 more source
Behavioral and Biochemical Effects of Monosodium Glutamate on Weaned Male Rats [PDF]
Veterinary Medical Journal - Giza, 2014 The present study investigates the effect of long term treatment (0.06,0.3 and 0.6g/kg b. wt., orally) with monosodium glutamate (MSG) on open field test and some biochemical parameters such as cortisol, serotonin (5-HT) and monoamine oxidase activity ...
Mervat Kamel +3 more
doaj +1 more source
Long-term low-dose oxytetracycline potentially leads to neurobehavioural changes
Ecotoxicology and Environmental Safety, 2021 Trace levels of oxytetracycline (OTC)—a veterinary antibiotic and feed additive—are widespread in the environment. Studies revealed that OTC potentially impairs thyroid function, which may affect neurobehaviour; however, the impact of exposure to ...
Yushu Qiu +8 more
doaj +1 more source