Results 31 to 40 of about 186,317 (243)

Targeting monoamine oxidases for the treatment of betel quid dependence: a potential pharmacological and neurobiological approach

Frontiers in Pharmacology
The trend of betel quid chewing has witnessed a gradual upsurge in recent years, indicating increased dependence on betel quid/betel-nut and complications of withdrawal. Dedicated efforts towards the development of effective cessation strategies are thus
Sorbomita Chakraborty, Abdul Hussain Choudhury, Indu Sharma, Yashmin Choudhury   +3 more
doaj   +1 more source

Parameters for Irreversible Inactivation of Monoamine Oxidase

Molecules, 2020
The irreversible inhibitors of monoamine oxidases (MAO) slow neurotransmitter metabolism in depression and neurodegenerative diseases. After oxidation by MAO, hydrazines, cyclopropylamines and propargylamines form a covalent adduct with the flavin ...
Rona R. Ramsay, Livia Basile, Antonin Maniquet, Stefanie Hagenow, Matteo Pappalardo, Maria Chiara Saija, Sharon D. Bryant, Alen Albreht, Salvatore Guccione   +8 more
doaj   +1 more source

An amine oxidase gene from mud crab, Scylla paramamosain, regulates the neurotransmitters serotonin and dopamine in vitro. [PDF]

PLoS ONE, 2018
Amine oxidase, which participates in the metabolic processing of biogenic amines, is widely found in organisms, including higher organisms and various microorganisms.
Junguo Liu, Ming Zhao, Wei Song, Lingbo Ma, Xiu Li, Fengying Zhang, Le Diao, Yan Pi, Keji Jiang   +8 more
doaj   +1 more source

Modulation of the TGF‐β/Smad Signaling Pathway by a Bioactive Oxidized Polygonati Rhizoma Polysaccharide Crosslinked Chitosan Hydrogel as Therapeutic Carrier for Parkinson's Disease Treatment

Advanced Science, EarlyView.
An injectable, self‐healing COPRP hydrogel integrates structurally defined oxidized Polygonati rhizoma polysaccharide with carboxymethyl chitosan through dynamic Schiff‐base crosslinking. The bioactive matrix scavenges reactive oxygen species, suppresses neuroinflammation, protects dopaminergic neurons, and supports sustained levodopa release.
Peng Dai, Jikuang Zhao, Chang Xue, Kailei Xu, Liang Yong, Zhuangwei Zhang, Yi Huang, Jianwei Shuai, Xianzhen Chen, Sheng Nie, Junpeng Xu   +10 more
wiley   +1 more source

Monoamine oxidase in neuronal cell death [PDF]

, 2008
Monoamine oxidase (MAO) is an oxidative enzyme that deaminates a variety of amine substrates, including the neurotransmitter dopamine. The enzymatic reaction requires molecular oxygen and produces hydrogen peroxide as a by-product.
Fitzgerald, J
core  

Platelet monoamine oxidase activity in diabetics.

Acta Médica Portuguesa, 1980
Platelet monoamine oxidase (MAO) activity was determined, using benzylamine as substract. Results are expressed as nM benzaldehyde/mg protein hour, at 37”. A total of 79 diabetics (40 M and 39 F) ranging in age from 3 to 70 years was studied.
Maria Azevedo, Francisca Fernandes, Pedro Lisboa, Carlos Manso   +3 more
doaj   +1 more source

Probiotic spore‐based bioresponsive drug delivery for reversing inflammatory bowel disease and its associated anxiety and depression

BMEMat, EarlyView.
A probiotic spore‐based drug delivery system (BCS‐Que@ApNPs) provides excellent targeted delivery, bioresponsive drug release, and long‐term retention (over 48 h), making it suitable for oral treatment of inflammatory bowel disease and its associated anxiety and depression.
Qingling Song, Beiyang Xue, Yao Li, Chuangxi Zhou, Junfei Yang, Yunfei Li, Lingwen Ding, Yun Zhang, Hongjuan Zhao, Lei Wang   +9 more
wiley   +1 more source

Antidepressant Misuse in Esports: A Review of Pharmacology, Adverse Effects, Pharmacokinetics and Biomatrix‐Based Detection for Anti‐Doping Applications

Drug Testing and Analysis, EarlyView.
This review highlights the misuse of antidepressants as potential cognitive‐enhancing agents in Esports. Despite pharmacological effects that overlap with those of psychostimulants, antidepressants remain an under‐recognised source of doping in Esports.
Kassim Ali Salum, Shao‐Hsin Hung, Meng‐Tsang Hsieh, Mei‐Chich Hsu, William Chih‐Wei Chang   +4 more
wiley   +1 more source

Stress reduces in vivo inhibition of monoamine oxidase by phenelzine in rat brain

, 1989
The level of inhibition of rat whole brain monoamine oxidase activity produced by the irreversible monoamine oxidase inhibitor phenelzine has been studied with or without concurrent cold restraint stress.
Glover, V., Sandler, M., Clow, A., Oxenkrug, G.F.   +3 more
core   +1 more source

Monoamine Oxidase Inhibitory Constituents of Propolis: Kinetics and Mechanism of Inhibition of Recombinant Human MAO-A and MAO-B

Molecules, 2014
Propolis is the resinous material that bees gather from leaf buds, flowers and vegetables. Propolis extracts contain constituents with a broad spectra of pharmacological properties and are important ingredients of popular dietary supplements.
Narayan D. Chaurasiya, Mohamed A. Ibrahim, Ilias Muhammad, Larry A. Walker, Babu L. Tekwani   +4 more
doaj   +1 more source