Results 81 to 90 of about 68,186 (189)

Drug Interaction With Advanced Therapies in Inflammatory Bowel Diseases: A Blind Spot to Tackle

United European Gastroenterology Journal, EarlyView.
Nathan Grellier, Julien Kirchgesner
wiley   +1 more source

Light‐Activated Pharmacological Tools for Exploring the Cholinergic System

Medicinal Research Reviews, Volume 45, Issue 4, Page 1251-1274, July 2025.
ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni, Giulia Galli, Clelia Dallanoce, Marco De Amici, Pau Gorostiza, Carlo Matera   +5 more
wiley   +1 more source

Liquiritigenin‐Rich Hydroalcoholic Extract of Brazilian Red Propolis Reduces Dyskinesia Induced by 3,4‐ Dihydroxyphenylalanine in Hemiparkinsonian Rats

Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 1, July 2025.
ABSTRACT The set‐up and progression of dyskinesia induced by 3,4‐dihydroxyphenylalanine (L‐DOPA) are strongly linked to oxidative stress and neuroinflammation. The aim of this work was to study and characterize the effects of the hydroalcoholic extract of Brazilian red propolis (HERP) on L‐DOPA–induced dyskinesia (LID) in hemiparkinsonian rats injected
Sheilla da Silva Barroso, Lorenna E. S. Lopes, Ana M. G. dos Santos, Reinaldo V. B. Neto, Bruno dos Santos Lima, Adriano A. de Souza Araújo, Juliana C. Cardoso, Patricia Severino, Eliana B. Souto, Margarete Z. Gomes   +9 more
wiley   +1 more source

Multifaceted Role of Microbiota‐Derived Indole‐3‐Acetic Acid in Human Diseases and Its Potential Clinical Application

The FASEB Journal, Volume 39, Issue 11, 15 June 2025.
The complexity of indole‐3‐acetic acid's (IAA's) role in human health and disease. IAA is a multifaceted compound with significant consequences for several physiological and pathological processes. ABSTRACT Indole‐3‐acetic acid (IAA) is recognized as a common plant growth hormone.
Nargis Shaheen, Jiaxing Miao, Boyu Xia, Yutong Zhao, Jing Zhao   +4 more
wiley   +1 more source

The Combination of Two Small Molecules Improves Neurological Parameters and Extends the Lifespan of C3H Strain Female Mice

Brain and Behavior, Volume 15, Issue 6, June 2025.
The small molecules RepSox and TCP were investigated for their geroprotective effects in aging C3H mice through intraperitoneal administration. Treatment resulted in improved neurological markers and physical parameters in older mice (16‐20 months), while younger treated mice (10‐13 months) showed increased maximum lifespan compared to controls.
Maria Vedunova, Olga Borysova, Elena Mitroshina, Ivan Morgunov, Alexander Fedintsev, Alexey Moskalev   +5 more
wiley   +1 more source

Drug‐Event Pairs as Indicators for the Detection of Adverse Drug Reactions during Hospitalization in Routinely Collected Electronic Data Sources

Clinical Pharmacology &Therapeutics, Volume 117, Issue 6, Page 1811-1819, June 2025.
Adverse drug reactions (ADRs) are a common cause of morbidity and mortality in hospitalized patients. Identification of ADRs in clinical practice, surveillance and research is essential to prevent further harm. The aim of this study was to assess the likelihood of drugs contributing to clinically important inpatient adverse events, in order to provide ...
Anna Maria Wermund, Annette Haerdtlein, Wolfgang Fehrmann, Clara Weglage, Tobias Dreischulte, Ulrich Jaehde   +5 more
wiley   +1 more source

New Approaches to the Treatment of Age-Related Brain Disorders [PDF]

, 2017
Two novel reversible enzyme inhibitors involved in monoamine metabolism are described. The novel and reversible inhibitors are the catechol-O-methyl-transferase (COMT) inhibitor, Ro 40-7592 (3,4-dihydroxy-4'-methyl-5-nitrobenzophenone), and the monoamine
Da Prada, M.
core  

Exploring Antioxidant Synergism Mechanism of 3D Printing Based Shanyao–Fuling–Yiyiren Decoction via Fuzzy Mathematical Method, Network Pharmacology, and In Vitro Experimental Validation

Food Science &Nutrition, Volume 13, Issue 6, June 2025.
SFY‐based polyherbal formulation was selected based on fuzzy mathematical model. The best combinations with synergistic effect were optimized and identified by central composite circumscribed design. Network pharmacology and molecular docking‐based approach revealed that the potential mechanisms of decoction against oxidant damage via multicomponent ...
Haoran Fan, Cai You, Chenxi Ren, Xiaoxiao Liu, Yining Feng, Ganghui Chu, Abdulla Yusuf, Chunbo Liu, Liemin Ruan, Jia Xu, Tianzhu Guan   +10 more
wiley   +1 more source

Neuropsychiatric Symptoms and White Matter Hyperintensities in Older Cognitively Unimpaired Men Versus Women

International Journal of Geriatric Psychiatry, Volume 40, Issue 6, June 2025.
ABSTRACT Objectives We aimed to examine association patterns of white matter hyperintensities (WMH) with neuropsychiatric symptoms (NPS) in men versus women. Methods We performed a cross‐sectional analysis of data acquired from the National Alzheimer's Coordinating Center database.
Ioannis Liampas, Daniil Tsirelis, Silvia Demiri, Vasileios Siokas, Antonia Tsika, Elli Zoupa, Polyxeni Stamati, Lambros Messinis, Grigorios Nasios, Efthimios Dardiotis   +9 more
wiley   +1 more source

Hepatotoxicity induced by greater celandine (Chelidonium majus L.): a review of the literature [PDF]

, 2017
The available literature assessing Chelidonium majus L. (CM) hepatotoxicity potential, and its risk to benefit assessment has been reviewed in this paper.
Busardò, F. P, DI LUCA, Natale Mario, Gentili, S, Graziano, Silvia, Mannocchi, Giulio, Marinelli, Enrico, Pantano, Flaminia   +6 more
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