Results 81 to 90 of about 73,810 (208)

Seasonal variation of serotonin turnover in human cerebrospinal fluid, depressive symptoms and the role of the 5-HTTLPR. [PDF]

, 2013
Studying monoaminergic seasonality is likely to improve our understanding of neurobiological mechanisms underlying season-associated physiological and pathophysiological behavior.
Bakker, SC, Boks, MPM, Borgdorff, P, Bruins, P, Buizer-Voskamp, JE, Cantor, RM, DeYoung, J, Eijkemans, MJC, Horvath, S, Kahn, RS, Lentjes, E, Lu, A, Luykx, JJ, Ophoff, RA, Strengman, E, van Dongen, EPA, van Geloven, N   +16 more
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Neurogenic Stuttering and Lateralized Motor Deficits Induced by Tranylcypromine

Behavioural Neurology, 1994
A case of neurogenic stuttering induced by the monoamine oxidase inhibitor tranylcypromine is described. The association of neurogenic stuttering with acquired lateralized motor deficits in the patient described is discussed with reference to current ...
J. D. Duffy
doaj   +1 more source

Synthesis and Biological Evaluation of New Thiosemicarbazone Derivative Schiff Bases as Monoamine Oxidase Inhibitory Agents

Molecules, 2017
Twenty-six novel thiosemicarbazone derivative B1–B26 were synthesized via condensation reactions between the corresponding thiosemicarbazides and aldehydes.
Betül Kaya Çavuşoğlu, Begüm Nurpelin Sağlık, Derya Osmaniye, Serkan Levent, Ulviye Acar Çevik, Abdullah Burak Karaduman, Yusuf Özkay, Zafer Asım Kaplancıklı   +7 more
doaj   +1 more source

Assessment of the direct and indirect effects of MPP+ and dopamine on the human proteasome: implications for Parkinson's disease aetiology [PDF]

, 2008
Mitochondrial impairment, glutathione depletion and oxidative stress have been implicated in the pathogenesis of Parkinson’s disease (PD), linked recently to proteasomal dysfunction.
Beck, KE, Billett, EE, Caneda-Ferrón, B, Costa, T, De, Girolamo, Layfield, R   +5 more
core   +1 more source

Mechanism-based tuning of insect 3,4-dihydroxyphenylacetaldehyde synthase for synthetic bioproduction of benzylisoquinoline alkaloids

Nature Communications, 2019
Bioproduction of tetrahydropapaveroline (THP) is limited by the specificity of monoamine oxidase (MAO). Here, the authors identify an insect 3,4-dihydroxyphenylacetaldehyde synthase (DHPAAS) that can bypass MAO for direct aldehyde production and ...
Christopher J. Vavricka, Takanobu Yoshida, Yuki Kuriya, Shunsuke Takahashi, Teppei Ogawa, Fumie Ono, Kazuko Agari, Hiromasa Kiyota, Jianyong Li, Jun Ishii, Kenji Tsuge, Hiromichi Minami, Michihiro Araki, Tomohisa Hasunuma, Akihiko Kondo   +14 more
doaj   +1 more source

Structures and mechanism of the monoamine oxidase family

Biomolecular Concepts, 2011
Members of the monoamine oxidase family of flavoproteins catalyze the oxidation of primary and secondary amines, polyamines, amino acids, and methylated lysine side chains in proteins.
Gaweska Helena, Fitzpatrick Paul F.
doaj   +1 more source

3-Coumaranone derivatives as inhibitors of monoamine oxidase

Drug Design, Development and Therapy, 2015
Adriaan S Van Dyk,1,2 Jacobus P Petzer,1,2 Anél Petzer,1 Lesetja J Legoabe1 1Centre of Excellence for Pharmaceutical Sciences, 2Pharmaceutical Chemistry, School of Pharmacy, North-West University, Potchefstroom, South Africa Abstract: The ...
Van Dyk AS, Petzer JP, Petzer A, Legoabe LJ   +3 more
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New Approaches to the Treatment of Age-Related Brain Disorders [PDF]

, 2017
Two novel reversible enzyme inhibitors involved in monoamine metabolism are described. The novel and reversible inhibitors are the catechol-O-methyl-transferase (COMT) inhibitor, Ro 40-7592 (3,4-dihydroxy-4'-methyl-5-nitrobenzophenone), and the monoamine
Da Prada, M.
core  

Effect of Hydroxytyrosol Derivatives of Donepezil on the Activity of Enzymes Involved in Neurodegenerative Diseases and Oxidative Damage

Molecules
Monoamine oxidase and xanthine oxidase inhibitors represent useful multi-target drugs for the prevention, attenuation, and treatment of oxidative damage and neurodegenerative disorders.
Antonio D’Errico, Rosarita Nasso, Rosario Rullo, Jessica Maiuolo, Paola Costanzo, Sonia Bonacci, Manuela Oliverio, Emmanuele De Vendittis, Mariorosario Masullo, Rosaria Arcone   +9 more
doaj   +1 more source

Efficacy, safety, and patient preference of monoamine oxidase B inhibitors in the treatment of Parkinson's disease

Patient Preference and Adherence, 2011
Bradley J RobottomDepartment of Neurology, University of Maryland School of Medicine, Baltimore, MD, USAAbstract: Parkinson's disease (PD) is the second most common neurodegenerative disease and the most treatable.
Bradley J Robottom
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