Discovery of monoamine oxidase inhibitors by medicinal chemistry approaches.
Medchemcomm, 2019 Neuropsychiatric disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD) and depression, have seriously inconvenienced the lives of patients.
Hong R, Li X.
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Monoamine Oxidase Inhibitors in Drug Discovery Against Parkinson’s Disease: An Update [PDF]
PharmaceuticalsBackground: Parkinson’s disease (PD) is a progressive neurodegenerative disorder with substantial socioeconomic impact, characterized by the gradual loss of dopaminergic neurons, dopamine deficiency, and pathological processes such as neuroinflammation ...
Luana Vergueiro Ribeiro +3 more
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2-acetylphenol analogs as potent reversible monoamine oxidase inhibitors [PDF]
Drug Design, Development and Therapy, 2015 Lesetja J Legoabe,1 Anél Petzer,1 Jacobus P Petzer1,21Centre of Excellence for Pharmaceutical Sciences, 2Department of Pharmaceutical Chemistry, School of Pharmacy, North-West University, Potchefstroom, South AfricaAbstract: Based on a previous ...
Legoabe LJ, Petzer A, Petzer JP
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Piperidine: A Versatile Heterocyclic Ring for Developing Monoamine Oxidase Inhibitors [PDF]
ACS Omega, 2023 Jayalakshmi Jayan +11 more
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Monoamine Oxidase-A Occupancy by Moclobemide and Phenelzine: Implications for the Development of Monoamine Oxidase Inhibitors. [PDF]
Int J Neuropsychopharmacol, 2015 Background: Monoamine oxidase inhibitors (MAOIs) are being developed for major depressive disorder, Alzheimer’s, and Parkinson’s Disease. Newer MAOIs have minimal sensitivity to tyramine, but a key limitation for optimizing their development is that ...
Chiuccariello L +10 more
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A Peroxidase-linked Spectrophotometric Assay for the Detection of Monoamine Oxidase Inhibitors. [PDF]
Iran J Pharm Res, 2016 To develop a new more accurate spectrophotometric method for detecting monoamine oxidase inhibitors from plant extracts, a series of amine substrates were selected and their ability to be oxidized by monoamine oxidase was evaluated by the HPLC method and
Zhi K, Yang Z, Sheng J, Shu Z, Shi Y.
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Monoamine oxidase inhibitors [PDF]
Anaesthesia, 1964 Publisher Summary This chapter describes the various classes of chemical compounds, which have an inhibitory action on monoamine oxidase (MAO). The chapter discusses the current theories of the function of monoamine oxidase and the possible mechanism by which the MAO inhibitors (MAOI) react with MAO.
Gerald Garmany, R.R.P. Warner
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Molecular docking approach of monoamine oxidase B inhibitors for identifying new potential drugs: Insights into drug-protein interaction discovery [PDF]
Journal of Cell and Molecular Research, 2013 Monoamine oxidase (EC, 1.4.3.4) or amine oxidoreductase catalyzes the oxidative deamination of biogenic amines. Abnormal action of the monoamine oxidase B has been associated with neurological dysfunctions including parkinson´s disorder.
Salimeh Raeisi
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Monoamine oxidase inhibitors and neuroprotective mechanisms
Psychiatry and Clinical Psychopharmacology, 2021 There has been a resurgence of interest in recent years in monoamine oxidase inhibitors, primarily because of the demonstrated neuroprotective and/ or neurorescue properties of several of these drugs in a variety of toxic situations in vivo and in vitro.
Glen Baker +4 more
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International Journal of Molecular Sciences, 2022 Synucleinopathies are a group of neurodegenerative disorders caused by the accumulation of toxic species of α-synuclein. The common clinical features are chronic progressive decline of motor, cognitive, behavioral, and autonomic functions.
M. Naoi, W. Maruyama, M. Shamoto‐Nagai
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