Effects of Natural Monoamine Oxidase Inhibitors on Anxiety-Like Behavior in Zebrafish. [PDF]
Front Pharmacol, 2021 Monoamine oxidases (MAO) are a valuable class of mitochondrial enzymes with a critical role in neuromodulation. In this study, we investigated the effect of natural MAO inhibitors on novel environment-induced anxiety by using the zebrafish novel tank ...
Jaka O +8 more
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Natural based piperine derivatives as potent monoamine oxidase inhibitors: an in silico ADMET analysis and molecular docking studies. [PDF]
BMC Chem, 2020 Neurodegenerative disorders follow numerous pathological ways concerning overexpression of monoamine oxidase and formation of reactive oxygen species.
Dhiman P, Malik N, Khatkar A.
europepmc +2 more sources
Different Generations of Type-B Monoamine Oxidase Inhibitors in Parkinson's Disease: From Bench to Bedside. [PDF]
Curr Neuropharmacol, 2019 Three inhibitors of type-B monoamine oxidase (MAOB), selegiline, rasagiline, and safinamide, are used for the treatment of Parkinson’s disease (PD). All three drugs improve motor signs of PD, and are effective in reducing motor fluc-tuations in patients ...
Alborghetti M, Nicoletti F.
europepmc +2 more sources
Molecular docking approach of monoamine oxidase B inhibitors for identifying new potential drugs: Insights into drug-protein interaction discovery [PDF]
Journal of Cell and Molecular Research, 2013 Monoamine oxidase (EC, 1.4.3.4) or amine oxidoreductase catalyzes the oxidative deamination of biogenic amines. Abnormal action of the monoamine oxidase B has been associated with neurological dysfunctions including parkinson´s disorder.
Salimeh Raeisi
doaj +1 more source
Monoamine Oxidase-B Inhibitors for the Treatment of Parkinson’s Disease: Past, Present, and Future
Journal of Parkinson's Disease, 2021 Monoamine oxidase-B (MAO-B) inhibitors are commonly used for the symptomatic treatment of Parkinson’s disease (PD). MAO-B inhibitor monotherapy has been shown to be effective and safe for the treatment of early-stage PD, while MAO-B inhibitors as ...
Yu-yan Tan, P. Jenner, S. Chen
semanticscholar +1 more source
Discovery of monoamine oxidase inhibitors by medicinal chemistry approaches.
Medchemcomm, 2019 Neuropsychiatric disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD) and depression, have seriously inconvenienced the lives of patients.
Hong R, Li X.
europepmc +2 more sources
Jurnal Kimia Riset, 2023 Kratom (Mitragyna speciosa Korth) is a tropical plant originating from Southeast Asia that predominantly contains alkaloid compounds and can potentially maintain levels of monoamine compounds in the body to treat depression.
Dandi Irawan +2 more
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Synthesis of New Lithium- and Monoamine-Intercalated Superconductors Li$_x$(C$_n$H$_{2n+3}$N)$_y$Fe$_{1-z}$Se ($n$ = 6, 8, 18) with the Dramatically Expanded Interlayer Spacing [PDF]
J. Phys. Soc. Jpn. 89, 115002 (2020), 2020 New superconductors, Li$_x$(C$_n$H$_{2n+3}$N)$_y$Fe$_{1-z}$Se ($n$ = 6, 8, 18), have been synthesized via the co-intercalation of linear monoamines together with Li into FeSe. The distance between neighboring Fe layers expands up to 55.7 {\AA} for n = 18, which is much larger than the previous record of 19 {\AA} in the FeSe-based intercalation ...
arxiv +1 more source
Antioxidants, 2023 Oxidative catabolism of monoamine neurotransmitters by monoamine oxidases (MAOs) produces reactive oxygen species (ROS), which contributes to neuronal cells’ death and also lowers monoamine neurotransmitter levels.
Ahmed H. E. Hassan +14 more
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