Results 31 to 40 of about 101,271 (322)
Pathophysiology of Depression: Stingless Bee Honey Promising as an Antidepressant
Molecules, 2022 Depression is a debilitating psychiatric disorder impacting an individual’s quality of life. It is the most prevalent mental illness across all age categories, incurring huge socio-economic impacts.
Fatin Haniza Zakaria +3 more
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2-acetylphenol analogs as potent reversible monoamine oxidase inhibitors. [PDF]
Drug Des Devel Ther, 2015 Lesetja J Legoabe,1 Anél Petzer,1 Jacobus P Petzer1,21Centre of Excellence for Pharmaceutical Sciences, 2Department of Pharmaceutical Chemistry, School of Pharmacy, North-West University, Potchefstroom, South AfricaAbstract: Based on a previous ...
Legoabe LJ, Petzer A, Petzer JP.
europepmc +2 more sources
Molecules, 2021 The multi-target-directed ligands (MTDLs) strategy is encouraged for the development of novel modulators targeting multiple pathways in the neurodegenerative cascade typical for Alzheimer’s disease (AD). Based on the structure of an in-house irreversible
Tjaša Mazej +4 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Mucosal epithelial cell integrity is an important component of innate immunity and it protects the host from an environment rich in microorganisms. Virulence factors from Gram-negative bacteria [e.g.
Edward E. Putnins +2 more
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Computer-aided approach for the identification of lead molecules as the inhibitors of cholinesterase’s and monoamine oxidases: Novel target for the treatment of Alzheimer disease [PDF]
Journal of the Serbian Chemical SocietyMolecular docking is a promising and reliable technology for the purpose of discovering lead compounds via virtual screening. In addition to allowing for the testing of a large number of compounds, it also allows for the determination of how the selected
Ejaz Syeda Abida +4 more
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In silico identification of potential natural product inhibitors of human proteases key to SARS-CoV-2 infection [PDF]
Molecules 2020, 25(17), 3822, 2020 Presently, there are no approved drugs or vaccines to treat COVID-19 which has spread to over 200 countries and is responsible for over 3,65,000 deaths worldwide. Recent studies have shown that two human proteases, TMPRSS2 and cathepsin L, play a key role in host cell entry of SARS-CoV-2.
arxiv +1 more source
Molecules, 2022 Monoamine oxidases (MAOs) are attractive targets in drug design. The inhibition of one of the isoforms (A or B) is responsible for modulating the levels of different neurotransmitters in the central nervous system, as well as the production of reactive ...
Marco Mellado +9 more
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Coumarin analogue 3-methyl-7H-furo[3,2-g] chromen-7-one as a possible antiparkinsonian agent
Biomédica: revista del Instituto Nacional de Salud, 2019 Introduction: Parkinson’s disease is the second most common neurodegenerative disease. Monoamine oxidase B inhibitors are used in the treatment of this disease concomitantly with levodopa or as monotherapy.
María del Pilar Olaya +4 more
doaj +1 more source
A review on coumarin backbone: An attractive scaffold for promising bioactive compounds [PDF]
المجلة العراقية للصيدلة, 2022 Background: Coumarin moiety is found in many naturally occurring products that have been used for many decades in traditional medicine around the world.
Sara Jasim, Yasser Mustafa
doaj +1 more source
The treatment of Parkinson's disease using MAO-B inhibitors [PDF]
, 2017 Monoamine Oxidase Inhibitors have sparked great controversy in the treatment of idiopathic Parkinson’s Disease. There is little doubt that Monoamine Oxidase Inhibitors work synergistically with Levodopa to reduce several major debilitating symptoms ...
Parsons, Austin
core +1 more source