N-Hydroxy-N-Propargylamide Derivatives of Ferulic Acid: Inhibitors of Cholinesterases and Monoamine Oxidases [PDF]
Molecules, 2022 Alzheimer’s disease (AD) is a complex disorder characterized by impaired neurotransmission in cholinergic and monoaminergic neurons, which, in combination with the accumulation of misfolded proteins and increased oxidative stress, leads to the typical ...
Óscar M. Bautista-Aguilera +6 more
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Early Life Stress Induced DNA Methylation of Monoamine Oxidases Leads to Depressive-Like Behavior [PDF]
Frontiers in Cell and Developmental Biology, 2020 Major depressive disorder (MDD) is coming to be the regarded as one of the leading causes for human disabilities. Due to its complicated pathological process, the etiology is still unclear and the treatment is still targeting at the monoamine ...
Qiuyue Xu +5 more
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Inhibition of Monoamine Oxidases by Pyridazinobenzylpiperidine Derivatives [PDF]
MoleculesMonoamine oxidase inhibitors (MAOIs) have been crucial in the search for anti-neurodegenerative medications and continued to be a vital source of molecular and mechanistic diversity.
Jong Min Oh +8 more
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Enantioselective Interactions of Anti-Infective 8-Aminoquinoline Therapeutics with Human Monoamine Oxidases A and B [PDF]
Pharmaceuticals, 2021 8-Aminoquinolines (8-AQs) are an important class of anti-infective therapeutics. The monoamine oxidases (MAOs) play a key role in metabolism of 8-AQs. A major role for MAO-A in metabolism of primaquine (PQ), the prototypical 8-AQ antimalarial, has been ...
Narayan D. Chaurasiya +5 more
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In Vitro Evaluation of Novel Furo[3,2-c]coumarins as Cholinesterases and Monoamine Oxidases Inhibitors [PDF]
MoleculesCoumarin represents a privileged structural motif that is quite common in nature-derived and synthetic bioactive molecules. Some of us have recently described the straightforward preparation of complex furo[3,2-c]coumarins through a sequential double ...
Mariagrazia Rullo +10 more
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Monoamine oxidases activity maintains endometrial monoamine homeostasis and participates in embryo implantation and development [PDF]
BMC BiologyBackground Monoamine oxidases (MAOs) is an enzyme that catalyzes the deamination of monoamines. The current research on this enzyme is focused on its role in neuropsychiatric, neurodevelopmental, and neurodegenerative diseases.
Zhe Yu +9 more
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Monoamine oxidases: A missing link between mitochondria and inflammation in chronic diseases ? [PDF]
Redox BiologyThe role of mitochondria spans from the regulation of the oxidative phosphorylation, cell metabolism and survival/death pathways to a more recently identified function in chronic inflammation.
Lise Beucher +3 more
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Natural Products Inhibitors of Monoamine Oxidases—Potential New Drug Leads for Neuroprotection, Neurological Disorders, and Neuroblastoma [PDF]
Molecules, 2022 Monoamine oxidase inhibitors (MAOIs) are an important class of drugs prescribed for treatment of depression and other neurological disorders. Evidence has suggested that patients with atypical depression preferentially respond to natural product MAOIs ...
Narayan D. Chaurasiya +3 more
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From warrior genes to translational solutions: novel insights into monoamine oxidases (MAOs) and aggression [PDF]
Translational Psychiatry, 2021 The pervasive and frequently devastating nature of aggressive behavior calls for a collective effort to understand its psychosocial and neurobiological underpinnings. Regarding the latter, diverse brain areas, neural networks, neurotransmitters, hormones,
Alexios-Fotios A. Mentis +3 more
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Effects of the Bark Resin Extract of Garcinia nigrolineata on Chronic Stress-Induced Memory Deficit in Mice Model and the In Vitro Monoamine Oxidases and β-Amyloid Aggregation Inhibitory Activities of Its Prenylated Xanthone Constituents [PDF]
Molecules, 2022 The present study describes investigation of the effects of the bark resin extract of Garcinia nigrolineata (Clusiaceae) on the cognitive function and the induction of oxidative stress in both frontal cortex and hippocampus by unpredictable chronic mild ...
Charinya Khamphukdee +8 more
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