Results 71 to 80 of about 10,352 (144)

Activation of the Lactate Receptor GPR81 Ameliorates Senescence Hallmarks and Improves Muscle Function in Cellular and Progeroid Models of Aging

Aging Cell, Volume 25, Issue 8, August 2026.
Skeletal muscle aging is associated with a decrease in expression of the lactate receptor GPR81. Treating senescent myoblasts in vitro and progeric mice in vivo with GPR81 agonist decreases intramyocellular lipid accumulation and reverses hallmarks of aging. ABSTRACT Skeletal muscle aging is associated with increased lipid accumulation, or myosteatosis,
Pihu Mehrotra, Sai Harsha Bhamidipati, Pedro Lei, John Toftegaard, Debanik Choudhury, Maryam Elsayed, Yali Zhang, Jianmin Wang, Shweta Chitkara, G. Ekin Atilla‐Gokcumen, Song Liu, Stelios T. Andreadis   +11 more
wiley   +1 more source

Identification of drug repurposing candidates for the treatment of polycystic kidney disease

British Journal of Pharmacology, Volume 183, Issue 16, Page 5082-5101, August 2026.
Background and Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end‐stage renal disease with limited treatment options. Drug repurposing offers a promising strategy to find effective treatments. Experimental Approach We identified birinapant, bardoxolone methyl and salicylic acid as repurposing candidates for ADPKD and
Alina Meyer, Paraskevi Sotiropoulou, Koussai Bouker, Dennis Svedberg, Rebekkah Hammar, Hester Bange, Per Larsson, André Mateus, Daniel R. Dietrich, Per Artursson   +9 more
wiley   +1 more source

Lysine l‐Lactylation: Bridging Metabolism, Chromatin and Disease

Cell Proliferation, Volume 59, Issue 8, August 2026.
Enzymatic regulation of KL‐la. The enzymatic regulation of KL‐la involves two distinct pathways for L‐lactate accumulation: intracellular production through glycolysis‐derived pyruvate conversion by lactate dehydrogenase (LDH) or direct cellular uptake via monocarboxylate transporters (MCTs). These L‐lactate pools fuel two distinct lactylation pathways—
Anoosha Malik, Muhammad Dilawar, Junguang Liao, Jie Zheng, Qitao Qian, Ming Xu, Sisi Lin, Xiaobo Zhu, Qiuwei Ge, Limin Jin, Guiqian Chen   +10 more
wiley   +1 more source

Sodium-coupled monocarboxylate transporter 1 interacts with the RING finger- and PDZ domain-containing protein PDZRN3

Sodium-coupled monocarboxylate transporter 1 interacts with the RING finger- and PDZ domain-containing protein PDZRN3
2019
openaire  

Phenylalanine Versus Tyrosine (Pos. 367/332 in MCT1/MCT4) in the Substrate Binding Site Defines Affinity and Preferred Directionality of Human Monocarboxylate Transporters 1-4. [PDF]

Acta Physiol (Oxf)
Menzel M, Dumitru ID, Peters J, Hövener JB, Pravdivtsev AN, Bondar AN, Beitz E.   +6 more
europepmc   +1 more source

Intrinsic Asymmetry in Weak Acid Transmembrane Transporters. [PDF]

Biomolecules
Jaeger E, Buss S, Beitz E.
europepmc   +1 more source

Analyses of astrocyte-neuron lactate shuttle transporter levels in brain tissues from people with HIV-associated neurocognitive impairment and Alzheimer's disease. [PDF]

NeuroImmune Pharm Ther
Boustani A, Laird A, Shu L, Sundermann EE, Moore DJ, Rissman R, Fields JA.   +6 more
europepmc   +1 more source

Metabolic Symbiosis and Vulnerability in the CNS Axon-Myelin Unit. [PDF]

Cell Mol Neurobiol
Miao K, Meng M, Liu L, Li M, Bai Y, Guo Y, Zhang G, Kong J, Mu J.   +8 more
europepmc   +1 more source

Immune cross talk and therapeutic advances in lactate metabolism in the tumor microenvironment (Review). [PDF]

Exp Ther Med
Liu M, Su K.
europepmc   +1 more source

Glial lactate metabolism and transport in Alzheimer's disease. [PDF]

Front Aging Neurosci
Wang Y, Feng B, Hong R, Qiu D, Zhao J, Zhao L.   +5 more
europepmc   +1 more source