Results 131 to 140 of about 97,734 (211)

Protein Lactylation in Cancer: From Mechanisms to Therapy

MedComm, Volume 7, Issue 11, November 2026.
Increased glycolysis and lactate accumulation promote histone and nonhistone protein lactylation, linking tumor metabolic reprogramming to treatment adaptation. Lactylation enhances DNA repair, suppresses antitumor immunity, strengthens antioxidant defenses, and facilitates cell‐cycle checkpoint escape, collectively promoting resistance to chemotherapy,
Wentian Huang, Ping Hu, Shun Wang, Xide Zhang, Ziran Ye, Shengqiang Chen, Fu Gao, Yuanyuan Chen, Yanyong Yang   +8 more
wiley   +1 more source

Skeletal muscle phenotype of breath‐hold divers reveals adaptations towards metabolic efficiency under hypoxia

The Journal of Physiology, EarlyView.
Anthony Richard Bain
wiley   +1 more source

Histone Modifications at the Intersection of Aging, Neuroinflammation and Metabolism in Alzheimer's Disease

Aging Cell, Volume 25, Issue 11, November 2026.
This review examines how histone modifications integrate aging, metabolic dysfunction and neuroinflammation to shape persistent, cell‐type‐specific chromatin states in Alzheimer's disease. By distinguishing causal regulation from association through perturbation, persistence and reversibility, it highlights metabolic–epigenetic feedback loops and ...
Junyi Liang, Huawen Cao, Xiumin Ren, Nan Sha, Xueqing Han, Ling Jiang, Bin Liu, Weiming Zhao   +7 more
wiley   +1 more source

Lactate Transporters Expression in Tumor of Balb/c Mice Bearing Breast Cancer after Endurance Training

Armaghane Danesh Bimonthly Journal, 2014
Background & aim: Changes in the metabolism of cancer cells plays a major role in the survival and their expansion. The aim of this study was to determine expression of lactate transmitters in Balb/c mice with breast cancer after endurance training ...
M Aveseh, R Nikooie, M Aminaie
doaj  

Liquid Compared to Solid Oral Formulations of the Thyroid Hormone Receptor Agonist Elunetirom Under Fasted and Fed Conditions in Healthy Participants

Clinical and Translational Science, Volume 19, Issue 11, November 2026.
ABSTRACT Elunetirom (ABX‐002) is a brain‐targeted, oral prodrug being developed for the adjunctive treatment of major depressive disorder and bipolar depression. The active moiety, LL‐340001, is a thyroid hormone receptor agonist with modest selectivity for beta over alpha thyroid hormone receptors. Upon entering the brain, the intended site of action,
Jason R. Harris, Aernout D. van Haarst, Jill Baccei, Bridgette Franey, Jason Everett, Kory George, Sabina Paglialunga, Kenneth Webster, Michelle Hillstrand, Chris Banfield, Thomas S. Scanlan, Gudarz Davar   +11 more
wiley   +1 more source

Immunocytochemical expression of monocarboxylate transporters in the human visual cortex at midgestation

, 2004
Lactate and the other monocarboxylates are a major energy source for the developing brain. We investigated the immunocytochemical expression of two monocarboxylate transporters, MCT1 and MCT2, in the human visual cortex between 13 and 26 post-ovulatory ...
Baud, O., Monier, A., Pellerin, L., Evrard, P., Fayol, L., Magistretti, P., Verney, C.   +6 more
core   +1 more source

Acute exercise‐induced improvements in cognition: Role of cerebral blood flow and metabolism

Experimental Physiology, Volume 111, Issue 11, Page 5074-5082, 1 November 2026.
Abstract Physical activity is widely recognized for its ability to promote brain health, with acute exercise transiently enhancing cognition and long‐term training attenuating cognitive decline. However, the mechanisms underlying these benefits remain incompletely understood.
Takeshi Hashimoto, Shigehiko Ogoh
wiley   +1 more source

Thyroid Hormone Transporters

, 2005
Thyroid hormone is essential for the development of the brain and the nervous system. Cellular entry is required for conversion of thyroid hormones by the intracellular deiodinases and for binding of T3 to its nuclear receptors.
Visser, Theo J., Visser, Theo, Jurgen Jansen, Milici, C, Milici, Carmelina, Friesema, Edith C.H.; id_orcid, Edith C.H. Friesema, Theo J. Visser, Friesema, Edith; id_orcid, Carmelina Milici, Jansen, Jurgen   +10 more
core   +1 more source

Exercise-Induced Lactate Release Mediates Mitochondrial Biogenesis in the Hippocampus of Mice via Monocarboxylate Transporters. [PDF]

Front Physiol, 2021
Park J, Kim J, Mikami T.
europepmc   +1 more source

Immunocytochemical expression of monocarboxylate transporters in the human visual cortex at midgestation

Lactate and the other monocarboxylates are a major energy source for the developing brain. We investigated the immunocytochemical expression of two monocarboxylate transporters, MCT1 and MCT2, in the human visual cortex between 13 and 26 post-ovulatory ...
Verney, Catherine, Fayol, Laurence, Baud, Olivier, Pellerin, Luc, Magistretti, Pierre, Monier, Anne, Evrard, Philippe   +6 more
core   +1 more source