Results 111 to 120 of about 97,734 (211)
A systemic analysis of monocarboxylate transporters in ovarian cancer and possible therapeutic interventions. [PDF]
Channels (Austin), 2023 Chatterjee P, Bhowmik D, Roy SS.
europepmc +1 more source
Warburg redefined: Metabolites, mitochondria and macrophages in immune regulation
The Journal of Physiology, EarlyView.Abstract figure legend Following pro‐inflammatory stimulation, macrophages undergo Warburg‐like metabolic rewiring that extends more than increased glycolysis. The non‐canonical functions of glycolytic enzymes and lactate accumulation control macrophage immune responses through multiple signalling pathways (a).
Yukun Min +2 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend CAF origins and plasticity give rise to distinct phenotypes with immunosuppressive functions in colorectal cancer and multiple myeloma. These distinct CAF phenotypes contribute to immunosuppressive tumour microenvironments through ECM remodelling, cytokine signalling and immune regulation.
Hui Mo +4 more
wiley +1 more source
MODULATORY ROLE OF THE MONOCARBOXYLATE TRANSPORTERS AT GLUTAMATERGIC POSTSYNAPSES
, 2022 Monocarboxylate transporters (MCTs) are a conserved family that facilitates the flow of monocarboxylates across membranes. MCTs are often required to adapt monocarboxylate bioavailability to cell requirements, a plasticity crucial in energy-demanding ...
GOUELLE, Cathy
core +1 more source
A Glial Interplay Regulates Junctional Architecture at the Blood–Brain Barrier of Drosophila
Glia, Volume 75, Issue 1, January 2027.Drosophila perineurial glia are required for septate junction formation at the blood–brain barrier. Glucose transport across the blood–brain barrier is maintained in the absence of perineurial glia. Perineurial glia ablation increases glucose‐only diet sensitivity.
Esteban G. Contreras +7 more
wiley +1 more source
Disruption of Lactate Metabolism in the Peripheral Nervous System Leads to Motor‐Selective Deficits
Glia, Volume 74, Issue 12, December 2026.To test the importance of lactate metabolism and shuttling between Schwann cells and neurons in the PNS, we selectively knocked out both LDHA and LDHB in motor neurons, sensory neurons, or Schwann cells. ABSTRACT Schwann cells (SCs) myelinate and provide trophic support to axons in the peripheral nervous system (PNS).
A. Joseph Bloom +11 more
wiley +1 more source
Inhibition of monocarboxylate transporters (MCT) 1 and 4 reduces exercise capacity in mice. [PDF]
Physiol Rep, 2022 Kitaoka Y, Takahashi K, Hatta H.
europepmc +1 more source
The FASEB Journal, Volume 40, Issue 21, 15 November 2026.Unacylated ghrelin (unAG) has been previously shown to acutely increase fatty acid oxidation (FAO) in skeletal muscle. 5 days of unAG administration to healthy male rats improved pyruvate tolerance, however this was not associated with changes in hepatic glucose‐production associated proteins.
Nicole M. Notaro +3 more
wiley +1 more source
Human monocarboxylate transporters accept and relay protons via the bound substrate for selectivity and activity at physiological pH. [PDF]
PNAS Nexus, 2023 Geistlinger K, Schmidt JDR, Beitz E.
europepmc +1 more source
Glia, Volume 74, Issue 11, November 2026.Relapsing colitis region‐specific microglial states beyond remission. Cortical microglia remain pro‐inflammatory and synapse‐disruptive, while hippocampal microglia shift toward a reparative program that maintains neuronal circuit stability. ABSTRACT Ulcerative colitis (UC) patients experience cycles of active gut inflammation and remission, with ...
Lorena Morton +6 more
wiley +1 more source