Results 101 to 110 of about 97,734 (211)
Frontiers in NutritionUlcerative colitis (UC) is characterized by gut dysbiosis and impaired mucosal metabolism, positioning short-chain fatty acids (SCFAs) as pivotal mediators. This review moves beyond general mechanisms, offering an in-depth analysis of SCFA metabolic fate,
Ziyi Ying +4 more
doaj +1 more source
A novel oral prodrug-targeting transporter MCT 1: 5-fluorouracil-dicarboxylate monoester conjugates
Asian Journal of Pharmaceutical Sciences, 2019 Monocarboxylate transporter 1 (MCT1) is responsible for oral absorption of short-chain monocarboxylic acids from small intestine, hence, it's likely to serve as an ideal design target for the development of oral prodrugs.
Yixin Sun +7 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Arboviruses induce virus‐specific alterations in placental structure and functional markers. Chikungunya virus (CHIKV) exposure was associated with reduced syncytiotrophoblast and syncytial knot areas, increased cytotrophoblast proliferation (Ki‐67) and thyroid transporter (MCT8) expression, reduced protective (P‐gp and BCRP ...
Cherley B. V. Andrade +13 more
wiley +1 more source
Expression pattern of thyroid hormone transporters in the postnatal mouse brain
Frontiers in Endocrinology, 2014 For a comprehensive description of the tissue-specific thyroidal state under normal as well as under pathophysiological conditions it is of utmost importance to include thyroid hormone (TH) transporters in the analysis as well.
Julia eMüller +2 more
doaj +1 more source
The monocarboxylate transporter family—Structure and functional characterization [PDF]
IUBMB Life, 2011 AbstractMonocarboxylate transporters (MCTs) catalyze the proton‐linked transport of monocarboxylates such as L‐lactate, pyruvate, and the ketone bodies across the plasma membrane. There are four isoforms, MCTs 1–4, which are known to perform this function in mammals, each with distinct substrate and inhibitor affinities.
openaire +3 more sources
Mitochondrial physiology in cardiac muscle of deer mice native to high altitude
The Journal of Physiology, EarlyView.Abstract figure legend High‐altitude deer mice exhibited evolved changes in mitochondrial energy metabolism and reactive oxygen species (ROS) management that may support cardiac performance under cold hypoxic conditions. High‐altitude mice had increased activity of lactate dehydrogenase (LDH) in the heart, probably enhancing the capacity for lactate ...
Ranim Saleem +3 more
wiley +1 more source
Monocarboxylate transporters and their functions in the retina
Acta Ophthalmologica, 2015 SummaryMonocarboxylate transporters (MCTs) have important functions in healthy tissues, being involved in the transmembrane transport of lactate and other monocarboxylic acids. MCTs are a family of transporters which is presently composed by 14 members, but only MCT1–4 have been biochemically characterized.
openaire +1 more source
Characterization of monocarboxylate transporter activity in hepatocellular carcinoma
World Journal of Gastroenterology, 2014 To assess the immunoexpression of hypoxia-related markers in samples from cirrhosis and primary and metastatic hepatocellular carcinoma (HCC).From a total of 5836 autopsies performed at the Pathology Department - University of Sao Paulo School of Medicine Hospital - from 2003 to 2009, 188 presented primary liver tumors.
Alves, Venâncio Avancini Ferreira +5 more
openaire +3 more sources
The Journal of Physiology, EarlyView.Abstract figure legend Competitive breath‐hold divers exhibit skeletal muscle characteristics indicative of enhanced blood‐muscle exchange capacity and increased lactate efflux potential. Top left: Participant characteristics, matched for age, height, body mass, and maximal oxygen uptake (V̇O2max${\dot{\mathrm{V}}}\rm{O}_{\rm{2max}}$).
Antonis Elia +7 more
wiley +1 more source
Energy Dynamics in the Brain: Contributions of Astrocytes to Metabolism and pH Homeostasis
Frontiers in Neuroscience, 2019 Regulation of metabolism is complex and involves enzymes and membrane transporters, which form networks to support energy dynamics. Lactate, as a metabolic intermediate from glucose or glycogen breakdown, appears to play a major role as additional ...
Joachim W. Deitmer +4 more
doaj +1 more source