Results 181 to 190 of about 97,734 (211)

Monocarboxylate transporter MCT1 is a target for immunosuppression

Nature Chemical Biology, 2005
Current immunosuppressive therapies act on T lymphocytes by modulation of cytokine production, modulation of signaling pathways or by inhibition of the enzymes of nucleotide biosynthesis. We have identified a previously unknown series of immunomodulatory compounds that potently inhibit human and rat T lymphocyte proliferation in vitro and in vivo in ...
Clare M, Murray, Raymond, Hutchinson, John R, Bantick, Graham P, Belfield, Amanda D, Benjamin, Diana, Brazma, Robert V, Bundick, I David, Cook, Robert I, Craggs, Susan, Edwards, Leslie R, Evans, Richard, Harrison, Elain, Holness, Andrew P, Jackson, Clive G, Jackson, Lee P, Kingston, Matthew W D, Perry, Andrew R J, Ross, Paul A, Rugman, Sasvinder S, Sidhu, Michael, Sullivan, David A, Taylor-Fishwick, P Craig, Walker, Yvonne M, Whitehead, David J, Wilkinson, Andrew, Wright, David K, Donald   +26 more
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Monocarboxylate transporters in subsarcolemmal and intermyofibrillar mitochondria

Biochemical and Biophysical Research Communications, 2004
Whether subsarcolemmal (SS) and intermyofibrillar (IMF) mitochondria contain monocarboxylate transporters (MCTs) is controversial. We have examined the presence of MCT1, 2, and 4 in highly purified SS and IMF mitochondria. These mitochondria were not contaminated with plasma membrane, sarcoplasmic reticulum or endosomal compartments, as the marker ...
Carley R, Benton, Shannon E, Campbell, Mio, Tonouchi, Hideo, Hatta, Arend, Bonen   +4 more
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Effects of streptozotocin-induced diabetes on markers of skeletal muscle metabolism and monocarboxylate transporter 1 to monocarboxylate transporter 4 transporters

Metabolism, 2002
Diabetes is known to alter both oxidative and glycolytic pathways in a fiber type-dependent manner. In various skeletal muscles of normal rats, monocarboxylate transporter 1 (MCT1) has been found to be highly correlated to lactate uptake, as well as to oxidative capacity, whereas the distribution and characteristics of MCT4 make it a good candidate for
Guillaume, Py, Karen, Lambert, Ollivier, Milhavet, Nicolas, Eydoux, Christian, Préfaut, Jacques, Mercier   +5 more
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Monocarboxylate Transporters are not Responsible for Cr3+ Transport from Endosomes

Biological Trace Element Research, 2012
Cr(3+), similar to Fe(3+), is transported into cells primarily via endocytosis as the metal-transferrin complex. As Cr(3+) ions are not readily reduced under biological conditions, the ion cannot be transported from endosomes by the same mechanism as iron that utilized divalent metal ion transporters.
Nicholas R, Rhodes, Paul A, LeBlanc, Jane F, Rasco, John B, Vincent   +3 more
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Transport of Hexoses and Monocarboxylic Acids

1983
Although the dependence of the mammalian brain, under normal conditions, on a regular supply of glucose from the bloodstream has been acknowledged for 50 years or more, ways by which glucose passes to the brain and how it travels within the brain were ignored until relatively recently.
openaire   +1 more source

Structural Basis of Human Monocarboxylate Transporter 1 Inhibition by Anti-Cancer Drug Candidates

Cell, 2021
Nan Wang, Chuangye Yan, Shuo Zhang
exaly  

Prognostic Value of Monocarboxylate Transporter 1 Overexpression in Cancer: A Systematic Review

International Journal of Molecular Sciences, 2023
Filipa Pinto-Ribeiro, Fatima Baltazar, Marta Costa   +2 more
exaly  

Monocarboxylate Transporters

2009
K. Pierre, L. Pellerin
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Contribution of Monocarboxylate Transporter 12 to Blood Supply of Creatine on the Sinusoidal Membrane of the Hepatocytes

American Journal of Physiology - Renal Physiology, 2021
Ken-Ichi Hosoya, Masanori Tachikawa, Yoshiyuki Kubo   +2 more
exaly  

Monocarboxylate transporter 1

AfCS-Nature Molecule Pages, 2009
openaire   +1 more source