Results 21 to 30 of about 204,978 (241)

A Novel Humanized Anti-Interleukin-6 Antibody HZ0408b With Anti-Rheumatoid Arthritis Therapeutic Potential

Frontiers in Immunology, 2022
Interleukin-6 (IL-6), a pleiotropic cytokine that regulates immune responses and inflammatory reactions, plays a pivotal role in the development of rheumatoid arthritis (RA).
Xiaolei Liu, Li Li, Qian Wang, Fengchao Jiang, Pei Zhang, Fei Guo, Hongjun Liu, Jian Huang, Jian Huang, Jian Huang   +9 more
doaj   +1 more source

Tocilizumab-coated solid lipid nanoparticles loaded with cannabidiol as a novel drug delivery strategy for treating COVID-19: A review

Frontiers in Immunology, 2023
Commonly used clinical strategies against coronavirus disease 19 (COVID-19), including the potential role of monoclonal antibodies for site-specific targeted drug delivery, are discussed here.
Aleksandra Zielińska, Piotr Eder, Jacek Karczewski, Marlena Szalata, Szymon Hryhorowicz, Karolina Wielgus, Milena Szalata, Agnieszka Dobrowolska, Atanas G. Atanasov, Atanas G. Atanasov, Atanas G. Atanasov, Ryszard Słomski, Eliana B. Souto, Eliana B. Souto   +13 more
doaj   +1 more source

Hemophagocytic Lymphohistiocytosis: Its Biochemical Basis and Clinical Implications [PDF]

Avicenna Journal of Medical Biochemistry
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome characterized by excessive cytokine activation. Its treatment remains extremely limited, with high mortality.
Sryla Punjadath, Ravi Kant
doaj   +1 more source

DRUG-INDUCED ENCEPHALOPATHY WITH IMPAIRED COGNITIVE FUNCTIONS DURING TOCILIZUMAB USE

Научно-практическая ревматология, 2019
Blockade of interleukin-6 (IL-6) is one of the most promising areas in the treatment of a number of immunoinflammatory diseases. Tocilizumab (TCZ), the first registered anti-IL-6 receptor monoclonal antibody, has been used effectively by rheumatologists ...
P. A. Shesternya, S. V. Prokopenko, E. Yu. Mozheiko, O. D. Gritsenko, T. V. Tupaeva, E. M. Kurts   +5 more
doaj   +1 more source

SARS-CoV-2 Spike Protein-Induced Interleukin 6 Signaling Is Blocked by a Plant-Produced Anti-Interleukin 6 Receptor Monoclonal Antibody

Vaccines, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the current COVID-19 pandemic, has caused more than 4.5 million deaths worldwide.
Collin Jugler, Haiyan Sun, Qiang Chen
doaj   +1 more source

The study of gp130/the inflammatory factors regulating osteoclast differentiation in rheumatoid arthritis

Biochemistry and Biophysics Reports, 2021
Rheumatoid arthritis (RA) is a chronic immune disease characterized by synovitis and bone destruction. The osteoclasts play a critical role in pathologic bone loss during inflammatory arthritis.
Renling Zou, Xiayang Huang, Peng Xu
doaj   +1 more source

Targeting Systemic Sclerosis from Pathogenic Mechanisms to Clinical Manifestations: Why IL-6?

Biomedicines, 2022
Systemic sclerosis (SS) is a chronic autoimmune disorder, which has both cutaneous and systemic clinical manifestations. The disease pathogenesis includes a triad of manifestations, such as vasculopathy, autoimmunity, and fibrosis.
Anca Cardoneanu, Alexandra Maria Burlui, Luana Andreea Macovei, Ioana Bratoiu, Patricia Richter, Elena Rezus   +5 more
doaj   +1 more source

Depletion of activated macrophages with a folate receptor-beta-specific antibody improves symptoms in mouse models of rheumatoid arthritis

Arthritis Research & Therapy, 2019
Objectives Most therapies for autoimmune and inflammatory diseases either neutralize or suppress production of inflammatory cytokines produced by activated macrophages (e.g., TNFα, IL-1, IL-6, IL-17, GM-CSF).
Yingwen Hu, Bingbing Wang, Jiayin Shen, Stewart A. Low, Karson S. Putt, Hans W. M. Niessen, Eric L. Matteson, Linda Murphy, Clemens Ruppert, Gerrit Jansen, Stephen J. Oliver, Yang Feng, Dimiter S. Dimitrov, Cheryl Nickerson-Nutter, Philip S. Low   +14 more
doaj   +1 more source

Dupilumab rapidly improves asthma control in predominantly anti‐IL5/IL5R pretreated Austrian real‐life severe asthmatics

Immunity, Inflammation and Disease, 2021
Dupilumab is a monoclonal antibody against the IL‐4 receptor alpha which has shown efficacy in T2 high severe asthmatics in phase 3 randomized controlled trials.
Andreas Renner, Katharina Marth, Karin Patocka, Marco Idzko, Wolfgang Pohl   +4 more
doaj   +1 more source

Efficacy of Epidural Administration of Anti-Interleukin-6 Receptor Antibody onto Spinal Nerve for Treatment of Sciatica

Global Spine Journal, 2012
Introduction Interleukin-6 (IL-6) is considered to play a crucial role in the radicular pain caused by lumbar spinal stenosis (LSS). However, efficacy of inhibition of IL-6 for sciatica in patients with LSS has not been clarified.
S. Ohtori, M. Miyagi, Y. Eguchi, G. Inoue, S. Orita, Y. Aoki, T. Ishikawa, H. Kamoda, M. Suzuki, G. Kubota, Y. Sakuma, Y. Oikawa, K. Takahashi   +12 more
doaj   +1 more source