Results 31 to 40 of about 198,185 (239)

Efficacy of Epidural Administration of Anti-Interleukin-6 Receptor Antibody onto Spinal Nerve for Treatment of Sciatica

Global Spine Journal, 2012
Introduction Interleukin-6 (IL-6) is considered to play a crucial role in the radicular pain caused by lumbar spinal stenosis (LSS). However, efficacy of inhibition of IL-6 for sciatica in patients with LSS has not been clarified.
S. Ohtori, M. Miyagi, Y. Eguchi, G. Inoue, S. Orita, Y. Aoki, T. Ishikawa, H. Kamoda, M. Suzuki, G. Kubota, Y. Sakuma, Y. Oikawa, K. Takahashi   +12 more
doaj   +1 more source

Dupilumab rapidly improves asthma control in predominantly anti‐IL5/IL5R pretreated Austrian real‐life severe asthmatics

Immunity, Inflammation and Disease, 2021
Dupilumab is a monoclonal antibody against the IL‐4 receptor alpha which has shown efficacy in T2 high severe asthmatics in phase 3 randomized controlled trials.
Andreas Renner, Katharina Marth, Karin Patocka, Marco Idzko, Wolfgang Pohl   +4 more
doaj   +1 more source

SATISFY‐JP, a phase II multicenter open‐label study on Satralizumab, an anti‐IL‐6 receptor antibody, use for the treatment of pulmonary arterial hypertension in patients with an immune‐responsive‐phenotype: Study protocol

Pulmonary Circulation, 2023
Pulmonary arterial hypertension (PAH), an intractable disease with a poor prognosis, is commonly treated using pulmonary vasodilators modulating the endothelin, cGMP, and prostacyclin pathway.
Yuichi Tamura, Rika Takeyasu, Tomohiro Takata, Naoki Miyazaki, Ryo Takemura, Michihiko Wada, Yudai Tamura, Kohtaro Abe, Ayako Shigeta, Yu Taniguchi, Shiro Adachi, Takumi Inami, Ichizo Tsujino, Nobuhiro Tahara, Masataka Kuwana   +14 more
doaj   +1 more source

Classic and Activating Chimeric Antigen Receptors PD-1 as an Element of Multi-Target Approach to the Treatment of Hematological and Solid Neoplasms

Клиническая онкогематология, 2023
Aim. To generate anti-PD-L1 CAR-T effectors carrying extracellular domain PD-1 as antigen-recognizing site and to study their cytolytic activity as well as to functionally assess the anti-PD-L1 CAR-T effectors in vitro with a view to apply them in multi ...
Kseniya Aleksandrovna Levchuk, A. A. Goldaev, E. A. Stolyarova, P. A. Mateikovich, A. Kh. Valiullina, E. R. Bulatov, A. V. Petukhov, A. A. Daks, N. A. Barlev, E. V. Baidyuk, Ya. G. Toropova   +10 more
doaj   +1 more source

Biologics in Asthma: A Molecular Perspective to Precision Medicine

Frontiers in Pharmacology, 2022
Recent developments in therapeutic strategies have provided alternatives to corticosteroids as the cornerstone treatment for managing airway inflammation in asthma.
Brittany Salter, Brittany Salter, Paige Lacy, Manali Mukherjee, Manali Mukherjee   +4 more
doaj   +1 more source

Galectin-3 binding protein stimulated IL-6 expression is impeded by antibody intervention in SARS-CoV-2 susceptible cell lines

Scientific Reports, 2022
COVID-19 is the global pandemic that affected our population in the past 2 years. Considerable research has been done to better understand the pathophysiology of this disease and to identify new therapeutic targets, especially for severe cases.
Ana Mendes-Frias, Valentina Gallo, Valentina Iacobelli, Roberta Gentile, Giovanni Antonini, Ricardo Silvestre, Stefano Iacobelli   +6 more
doaj   +1 more source

Experience of Vaccination of a Patient with Systemic Juvenile Idiopathic Arthritis (sJIA) with a 13-Valent Pneumococcal Conjugate Vaccine, prior to the Appointment of Therapy with Tocilizumab, an Anti-IL-6-Receptor Monoclonal Antibody

Current pediatrics, 2018
Background. Infections are the main cause of death for patients with autoimmune rheumatic diseases. In adult patients with rheumatoid arthritis (RA), mortality caused by respiratory infections is 2–5 times higher than in the population. One of the frequent infectious complications in the course of treatment with tocilizumab, the first-choice drug for ...
Daria D. Vankova, Ekaterina I. Alekseeva, Margarita А. Soloshenko, Tatiana М. Dvoriakovskaia, Ksenia B. Isaeva, Rina V. Denisova, Anna V. Mamutova, Mariya G. Rudnitskaya, Nikolay A. Mayansky, Natal’ya Е. Tkachenko   +9 more
openaire   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Changes in Iron Metabolism Induced by Anti-Interleukin-6 Receptor Monoclonal Antibody are Associated with an Increased Risk of Infection

Pharmaceuticals, 2019
(1) Background: Treatment of patients with rheumatoid arthritis (RA) with an anti-IL-6 receptor (anti-IL-6R) monoclonal antibody (tocilizumab) has been found to influence iron metabolism.
Renata Ribeiro, Frederico Batista, Filipe Seguro Paula, José Delgado Alves   +3 more
doaj   +1 more source

Prophylactic Tocilizumab Prior to Anti-CD19 CAR-T Cell Therapy for Non-Hodgkin Lymphoma

Frontiers in Immunology, 2021
Anti-CD19 chimeric antigen receptor T (CAR-T) cells have demonstrated activity against relapsed/refractory lymphomas. Cytokine release syndrome (CRS) and immune effector cell – associated neurotoxicity syndrome (ICANS) are well-known complications ...
Paolo F. Caimi, Gabriela Pacheco Sanchez, Ashish Sharma, Folashade Otegbeye, Nausheen Ahmed, Patricio Rojas, Seema Patel, Sarah Kleinsorge Block, Jennifer Schiavone, Kayla Zamborsky, Kirsten Boughan, Antoinette Hillian, Jane Reese-Koc, Mikhail Maschan, Boro Dropulic, Rafick-Pierre Sekaly, Marcos de Lima   +16 more
doaj   +1 more source