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Human monoclonal antibodies and monoclonal antibody multispecificity [PDF]

open access: yesBritish Journal of Cancer, 1987
The majority of human anti-tumour monoclonal antibodies (Mabs) isolated to date have been disappointing. Firstly, they react or cross react with intracellular cytoskeletal proteins or nuclear antigens and therefore are of limited value as blood borne agents.
A M, Campbell, P, Whitford, R E, Leake
openaire   +2 more sources

Monoclonal Antibodies

open access: yesDermatologic Clinics, 2015
Use of monoclonal antibodies (mAbs) has revolutionized cancer therapy. Approaches targeting specific cellular targets on the malignant cells and in tumor microenvironment have been proved to be successful in hematologic malignancies, including cutaneous lymphomas.
openaire   +3 more sources

Therapeutic Monoclonal Antibodies

open access: yesThe Keio Journal of Medicine, 2011
Over a hundred years has passed since the discovery of the "magic bullet" serum therapy by Kitasato and Behring, the first ever therapeutic use of antibodies. More than 80 years later, the investigation of immunoglobulin structure and function and the development of cell and molecular biology introduced the production of monoclonal antibodies (MoAbs ...
openaire   +3 more sources

NeuroMabSeq: high volume acquisition, processing, and curation of hybridoma sequences and their use in generating recombinant monoclonal antibodies and scFvs for neuroscience research [PDF]

open access: gold, 2023
Keith G. Mitchell   +12 more
openalex   +1 more source

State-specific Monoclonal Antibodies Identify an Intermediate State in Epsilon Protein Kinase C Activation [PDF]

open access: hybrid, 2004
Miriam C. Souroujon   +9 more
openalex   +1 more source

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