Results 1 to 10 of about 2,467,329 (421)

The Latest Battles Between EGFR Monoclonal Antibodies and Resistant Tumor Cells

Frontiers in Oncology, 2020
Epidermal growth factor receptor (EGFR) is a tyrosine kinase receptor involved in homeostatic regulation of normal cells and carcinogenesis of epithelial malignancies.
Wen-Qi Cai, Wen-Qi Cai, Li-Si Zeng, Li-Feng Wang, Ying-Ying Wang, Ying-Ying Wang, Jun-Ting Cheng, Jun-Ting Cheng, Ying Zhang, Ying Zhang, Zi-Wen Han, Zi-Wen Han, Yang Zhou, Yang Zhou, Shao-Li Huang, Xian-Wang Wang, Xian-Wang Wang, Xiao-Chun Peng, Xiao-Chun Peng, Ying Xiang, Ying Xiang, Zhaowu Ma, Zhaowu Ma, Shu-Zhong Cui, Hong-Wu Xin, Hong-Wu Xin   +25 more
doaj   +2 more sources

Pharmacokinetics of Monoclonal Antibodies

CPT: Pharmacometrics & Systems Pharmacology, 2017
Monoclonal antibodies (mAbs) have developed in the last two decades into the backbone of pharmacotherapeutic interventions in a variety of indications, with currently more than 40 mAbs approved by the US Food and Drug Administration, and several dozens ...
J. Ryman, B. Meibohm
semanticscholar   +4 more sources

Treatment patterns and factors associated with discontinuation of monoclonal antibodies [PDF]

SAGE Open Medicine
Background: Biological agents have revolutionized care in specialties such as oncology, immunology, infectious diseases, and genetic disorders, offering targeted actions on specific molecules or select immune cells. Monoclonal antibodies, known for their
Muzoon Matar Saleh Alkaabi, Syed Arman Rabbani, Padma GM Rao, Mai Ismail Mohamedelhassan   +3 more
doaj   +2 more sources

Kinetic Analysis and Epitope Mapping of Monoclonal Antibodies to Salmonella Typhimurium Flagellin Using a Surface Plasmon Resonance Biosensor [PDF]

Antibodies, 2019
Salmonella Typhimurium is one of the leading causes of foodborne diseases worldwide. Biosensors and immunoassays utilizing monoclonal antibodies are widely used for the detection and subtyping of S. Typhimurium.
Devendra Bhandari, Fur-Chi Chen, Shreya Hamal, Roger C. Bridgman   +3 more
doaj   +3 more sources

mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants

Nature, 2021
Jianliang Xu, Justin Dasilva, Sébastien Poncet   +2 more
exaly   +2 more sources

Human neutralizing antibodies elicited by SARS-CoV-2 infection

Nature, 2020
Jinfang Yu, Jincun Zhao, Jiwan Ge
exaly   +2 more sources

Extreme Point Sort Transformation Combined With a Long Short-Term Memory Network Algorithm for the Raman-Based Identification of Therapeutic Monoclonal Antibodies

Frontiers in Chemistry, 2022
Therapeutic monoclonal antibodies (mAbs) are a new generation of protein-based medicines that are usually expensive and thus represent a target for counterfeiters.
Jin Ling, Luxia Zheng, Mingming Xu, Gang Chen, Xiao Wang, Danzhuo Mao, Hong Shao   +6 more
doaj   +1 more source

Identification, Efficacy, and Stability Evaluation of Succinimide Modification With a High Abundance in the Framework Region of Golimumab

Frontiers in Chemistry, 2022
Succinimide (Asu) is the intermediate for asparagine deamidation in therapeutic proteins, and it can be readily hydrolyzed to form aspartate and iso-aspartate residues. Moreover, Asu plays an important role in the protein degradation pathways, asparagine
Tao Liu, Tao Liu, Tao Liu, Jin Xu, Jin Xu, Jin Xu, Jin Xu, Qingcheng Guo, Dapeng Zhang, Dapeng Zhang, Dapeng Zhang, Jun Li, Weizhu Qian, Weizhu Qian, Weizhu Qian, Huaizu Guo, Huaizu Guo, Huaizu Guo, Huaizu Guo, Xinli Zhou, Sheng Hou, Sheng Hou, Sheng Hou   +22 more
doaj   +1 more source

Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike

Nature, 2020
David D Ho, Manoj S Nair, Yaoxing Huang
exaly   +2 more sources

Identification of Immunogenic Linear B-Cell Epitopes in C. burnetii Outer Membrane Proteins Using Immunoinformatics Approaches Reveals Potential Targets of Persistent Infections

Pathogens, 2021
Coxiella burnetii is a global, highly infectious intracellular bacterium, able to infect a wide range of hosts and to persist for months in the environment. It is the etiological agent of Q fever—a zoonosis of global priority.
Sílvia da Silva Fontes, Fernanda de Moraes Maia, Laura Santa’Anna Ataides, Fernando Paiva Conte, Josué da Costa Lima-Junior, Tatiana Rozental, Matheus Ribeiro da Silva Assis, Adonai Alvino Pessoa Júnior, Jorlan Fernandes, Elba Regina Sampaio de Lemos, Rodrigo Nunes Rodrigues-da-Silva   +10 more
doaj   +1 more source