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Human monoclonal antibodies and monoclonal antibody multispecificity [PDF]
The majority of human anti-tumour monoclonal antibodies (Mabs) isolated to date have been disappointing. Firstly, they react or cross react with intracellular cytoskeletal proteins or nuclear antigens and therefore are of limited value as blood borne agents.
A M, Campbell, P, Whitford, R E, Leake
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Use of monoclonal antibodies (mAbs) has revolutionized cancer therapy. Approaches targeting specific cellular targets on the malignant cells and in tumor microenvironment have been proved to be successful in hematologic malignancies, including cutaneous lymphomas.
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Therapeutic Monoclonal Antibodies
Over a hundred years has passed since the discovery of the "magic bullet" serum therapy by Kitasato and Behring, the first ever therapeutic use of antibodies. More than 80 years later, the investigation of immunoglobulin structure and function and the development of cell and molecular biology introduced the production of monoclonal antibodies (MoAbs ...
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Anti-EGFR Monoclonal Antibody GT-MAB 5.2-GEX [PDF]
National Cancer Institute
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NeuroMabSeq: high volume acquisition, processing, and curation of hybridoma sequences and their use in generating recombinant monoclonal antibodies and scFvs for neuroscience research [PDF]
Keith G. Mitchell +12 more
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Anti-GITR Agonistic Monoclonal Antibody ASP1951 [PDF]
National Cancer Institute
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State-specific Monoclonal Antibodies Identify an Intermediate State in Epsilon Protein Kinase C Activation [PDF]
Miriam C. Souroujon +9 more
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