Results 91 to 100 of about 715,660 (339)
Monoclonal antibodies were generated against recombinant follicle-stimulating hormone (rec-FSH) from Japanese eel Anguilla japonica; rec-FSH was produced in Escherichia coli and purified using Ni-NTA Sepharose column chromatography.In support of our ...
Dae-Jung Kim+9 more
doaj
Qat-4 and Qat-5, new murine T-cell antigens governed by the Tla region and identified by monoclonal antibodies. [PDF]
G J Hämmerling+2 more
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ABSTRACT Background and Objectives Ofatumumab, a fully human anti‐CD20 monoclonal antibody, is effective in reducing relapses and disability progression in patients with multiple sclerosis. This study aimed to examine immune profile changes associated with ofatumumab in a prospective cohort of Chinese patients with relapsing–remitting multiple ...
Shu Yang+9 more
wiley +1 more source
A mathematical model for growth of solid tumors and combination therapy with an application to colorectal cancer [PDF]
We present a mathematical model, based on ordinary differential equations, for the evolution of solid tumors and their response to treatment. Specifically the effects of a cytotoxic agent and a monoclonal antibody are included as control term in the equations.
arxiv
CROSS-STIMULATION OF MONOCLONAL ANTIBODIES IN ANAMNESTIC RESPONSES [PDF]
Matthias Cramer, Dietmar G. Braun
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Therapeutic Monoclonal Antibodies
Over a hundred years has passed since the discovery of the "magic bullet" serum therapy by Kitasato and Behring, the first ever therapeutic use of antibodies. More than 80 years later, the investigation of immunoglobulin structure and function and the development of cell and molecular biology introduced the production of monoclonal antibodies (MoAbs ...
openaire +4 more sources
ABSTRACT This study assessed whether continued treatment with anti‐CGRP monoclonal antibodies (mAbs) is driven more by reductions in monthly migraine days (MMDs) or patients' global impression of change (PGIC), a patient‐reported outcome. Among 169 patients treated with anti‐CGRP mAbs, 21.3% discontinued due to ineffectiveness. PGIC responders (≥ 5) at
Marina Romozzi+4 more
wiley +1 more source
Effect of cancer drugs in patients with metastatic colorectal cancer in terms of mortality reduction
Background. Colorectal cancer (CRC) is the 4th most frequent cause of death among patients with malignant tumors worldwide. In 2012, approximately 1.3 million people were diagnosed with CRC, nearly 690 000 patients died.Objective: to assess the impact of
M. Yu. Fedyanin+4 more
doaj +1 more source
An Asymptotic Analysis of Bivalent Monoclonal Antibody-Antigen Binding [PDF]
Ligand-receptor interactions are fundamental to many biological processes. For example in antibody-based immunotherapies, the dynamics of an antibody binding with its target antigen directly influence the potency and efficacy of monoclonal antibody (mAb) therapies.
arxiv
Monoclonal gammopathy (Waldenstrom's macroglobulinaemia) producing specific red cell antibody. [PDF]
O. A. Oluboyede+5 more
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