Results 11 to 20 of about 2,599,480 (386)

The Latest Battles Between EGFR Monoclonal Antibodies and Resistant Tumor Cells

Frontiers in Oncology, 2020
Epidermal growth factor receptor (EGFR) is a tyrosine kinase receptor involved in homeostatic regulation of normal cells and carcinogenesis of epithelial malignancies.
Wen-Qi Cai, Wen-Qi Cai, Li-Si Zeng, Li-Feng Wang, Ying-Ying Wang, Ying-Ying Wang, Jun-Ting Cheng, Jun-Ting Cheng, Ying Zhang, Ying Zhang, Zi-Wen Han, Zi-Wen Han, Yang Zhou, Yang Zhou, Shao-Li Huang, Xian-Wang Wang, Xian-Wang Wang, Xiao-Chun Peng, Xiao-Chun Peng, Ying Xiang, Ying Xiang, Zhaowu Ma, Zhaowu Ma, Shu-Zhong Cui, Hong-Wu Xin, Hong-Wu Xin   +25 more
doaj   +2 more sources

Pharmacokinetics of Monoclonal Antibodies

CPT: Pharmacometrics & Systems Pharmacology, 2017
Monoclonal antibodies (mAbs) have developed in the last two decades into the backbone of pharmacotherapeutic interventions in a variety of indications, with currently more than 40 mAbs approved by the US Food and Drug Administration, and several dozens more in clinical development. This tutorial will review major drug disposition processes relevant for
Bernd Meibohm, Josiah T. Ryman
openaire   +4 more sources

Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys [PDF]

Nature, 2013
Human immunodeficiency virus type 1 (HIV-1)-specific monoclonal antibodies with extraordinary potency and breadth have recently been described. In humanized mice, combinations of monoclonal antibodies have been shown to suppress viraemia, but the ...
Barouch, Dan H., Beck, Matthew, Blackmore, Stephen, Borducchi, Erica N., Burton, Dennis R., Cabral, Crystal, Chakraborty, Arup K., Chang, Hui-Wen, Gupta, Sanjana, Klein, Florian, Lewis, Mark G., Liu, Jinyan, Moldt, Brian, Nkolola, Joseph P., Nussenzweig, Michel C., Oliveira, Thiago Y., Perry, James R., Poignard, Pascal, Rinaldi, William, Sanisetty, Srisowmya, Seaman, Michael S., Shekhar, Karthik, Smith, Jeffrey Y., Smith, Kaitlin M., Stephenson, Kathryn E., Whitney, James B.   +25 more
core   +4 more sources

Anti-Amyloid Monoclonal Antibodies for the Treatment of Alzheimer’s Disease

BioDrugs, 2023
Two monoclonal antibodies (mAbs), aducanumab and lecanemab, have received accelerated approval from the US FDA for initiation of treatment in early Alzheimer's disease patients who have proven β-amyloid pathology (Aβ).
Jeffrey L. Cummings, A. L. Osse, D. Cammann, Jayde Powell, Jingchun Chen   +4 more
semanticscholar   +1 more source

Neutralizing monoclonal antibodies for treatment of COVID-19

Nature reviews. Immunology, 2021
Several neutralizing monoclonal antibodies (mAbs) to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed and are now under evaluation in clinical trials.
P. Taylor, A. Adams, M. Hufford, I. de la Torre, K. Winthrop, R. Gottlieb   +5 more
semanticscholar   +1 more source

Reaction of Human Monoclonal Antibodies to SARS-CoV-2 Proteins With Tissue Antigens: Implications for Autoimmune Diseases

Frontiers in Immunology, 2021
We sought to determine whether immune reactivity occurs between anti-SARS-CoV-2 protein antibodies and human tissue antigens, and whether molecular mimicry between COVID-19 viral proteins and human tissues could be the cause.
A. Vojdani, E. Vojdani, Datis Kharrazian
semanticscholar   +1 more source

SARS-CoV-2 B.1.1.7 sensitivity to mRNA vaccine-elicited, convalescent and monoclonal antibodies

Nature, 2021
Transmission of SARS-CoV-2 is uncontrolled in many parts of the world; control is compounded in some areas by the higher transmission potential of the B.1.1.7 variant1, which has now been reported in 94 countries.
D. Collier, A. De Marco, I. Ferreira, B. Meng, R. Datir, A. Walls, Steven A Kemp S, J. Bassi, D. Pinto, C. Fregni, S. Bianchi, M. A. Tortorici, John E. Bowen, K. Culap, S. Jaconi, E. Cameroni, G. Snell, M. Pizzuto, A. F. Pellanda, C. Garzoni, A. Riva, A. Elmer, N. Kingston, B. Graves, Laura E. McCoy, Kenneth G. C. Smith, J. Bradley, Nigel James Temperton, L. Lourdes Ceron-Gutierrez, G. Barcenas-Morales, William T. Harvey, H. Virgin, A. Lanzavecchia, L. Piccoli, R. Doffinger, M. Wills, D. Veesler, D. Corti, Ravindra K. Gupta   +38 more
semanticscholar   +1 more source

Monoclonal Antibodies in Cancer Therapy

Antibodies, 2020
Monoclonal antibody-based immunotherapy is now considered to be a main component of cancer therapy, alongside surgery, radiation, and chemotherapy. Monoclonal antibodies possess a diverse set of clinically relevant mechanisms of action.
D. Zahavi, L. Weiner
semanticscholar   +1 more source

Monoclonal Antibodies as Neurological Therapeutics

Pharmaceuticals, 2021
Over the last 30 years the role of monoclonal antibodies in therapeutics has increased enormously, revolutionizing treatment in most medical specialties, including neurology.
Panagiotis Gklinos, Miranta Papadopoulou, Vid Stanulovic, Dimos D. Mitsikostas, Dimitrios Papadopoulos   +4 more
doaj   +1 more source

Broad neutralization of SARS-related viruses by human monoclonal antibodies

Science, 2020
Seeking broad protection As scientists develop therapeutic antibodies and vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the risk of emergent coronaviruses makes it important to also identify broadly protective antibodies.
Anna Z. Wec, D. Wrapp, A. Herbert, Daniel P. Maurer, Denise Haslwanter, M. Sakharkar, R. Jangra, M. Dieterle, A. Lilov, Deli Huang, Longping V. Tse, N. Johnson, C. Hsieh, Nianshuang Wang, J. Nett, E. Champney, Irina Burnina, Michael E. Brown, Shu Lin, M. Sinclair, Carl Johnson, Sarat Pudi, R. Bortz, A. Wirchnianski, Ethan Laudermilch, Catalina Florez, J. Fels, Cecilia M. O’Brien, B. Graham, D. Nemazee, D. Burton, R. Baric, J. Voss, K. Chandran, J. Dye, J. McLellan, L. Walker   +36 more
semanticscholar   +1 more source