Results 231 to 240 of about 1,044,682 (307)

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

Broadly neutralizing monoclonal antibodies against influenza A viruses: current insights and future directions. [PDF]

Front Microbiol
Mahrous NN, Alhumaidan OS, Alkhoshaiban AS, Tafish RT, Al-Ghnnam FF, Althubyani M, Al-Hubaysh A, Jamous YF.   +7 more
europepmc   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Effect of the Addition of Xianglian Granules to PD-1 Monoclonal Antibodies in Pancancer Patients. [PDF]

Biol Proced Online
Wu T, Li S, Shuang H, Li Y, Fu S, Jiang H, Zhang S, Du B, Lv J, Xia X, Cao S, Yao L, Pan P, Feng S, Li C, Zhou Z, Chen J, Zhong Y.   +17 more
europepmc   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Increased risk of infusion-related reactions switching between monoclonal antibodies for Alzheimer's disease: A case series. [PDF]

Alzheimers Dement (Amst)
Gopalakrishna G, Tandoc C, Joshi P.
europepmc   +1 more source

Add-on combination therapy with monoclonal antibodies: Implications for drug development. [PDF]

J Prev Alzheimers Dis
Cummings J, Burstein AH, Fillit H.
europepmc   +1 more source

The organ transplanted patient - immunological concepts and immunosuppression [PDF]

, 1991
Husberg, BS, Klintmalm, GBG, Starzl, TE
core  

Broadly neutralizing human monoclonal antibodies against BK polyomavirus genotypes. [PDF]

J Gen Virol
Duty JA, Kraus TA, Kumar M, Tortorella NA, Jimoh TO, Barrall EB, Pastrana DV, Buck CB, Moran TM, Tortorella D.   +9 more
europepmc   +1 more source

Complete and Rapid NMR Characterization of Therapeutic Monoclonal Antibodies via Differential Labeling of Fab Fragments in <i>Escherichia coli</i>. [PDF]

Anal Chem
Gagné D, Aubin Y.
europepmc   +1 more source