Results 221 to 230 of about 87,798 (246)
Some of the next articles are maybe not open access.
Monoclonal antibodies to prothrombin
Thrombosis Research, 1987Hybridoma technology was used for the production of murine monoclonal antibodies to bovine normal prothrombin. Hybrid cell cultures were assayed for the production of antibodies, both in the absence and presence of calcium ions, by Enzyme-Linked Immunosorbent Assay (ELISA). Antibody-producing cell lines were cloned two times and grown as ascites tumors.
O P, Malhotra, O, Sudilovsky
openaire +2 more sources
Monoclonal antibodies in oncology
Radiotherapy and Oncology, 1986Monoclonal antibodies (MCAs) can be used to differentiate between normal and neoplastic cells and thus exploited for diagnostic and, ultimately, therapeutic gain. The evidence for the existence of human tumour antigens is reviewed. Several areas of diagnosis are already benefiting from the application of the monoclonal technology.
S Y, Chan, K, Sikora
openaire +2 more sources
Therapeutic monoclonal antibodies
The Lancet, 2000The therapeutic potential of monoclonal antibodies (mAb) was quickly realised after the hybridoma technique allowed their development in the mid 1970s. Chimeric humanised and fully humanised mAb can now be made by recombinant engineering. About a quarter of all biotech drugs in development are mAb, and around 30 products are in use or being ...
openaire +2 more sources
Radiolabeled Monoclonal Antibodies
AORN Journal, 1995ABSTRACTMonoclonal antibodies (MoAbs) are biologically engineered proteins designed to bind to antigens emanating from tumor cells. Selected radioactive isotopes are fused with MoAbs to allow radioimmunodetection or external imaging of metastatic deposits in patients with colon cancer.
C L, Brumley, J A, Kuhn
openaire +2 more sources
Polyclonal and Monoclonal Antibodies
2000The breadth of repertoire yet beautiful specificity of the antibody response is the key to its physiological efficacy in vivo; it also underpins the attractiveness of antibodies as laboratory and clinical reagents. One aspect of the body's reaction to invasion by a microorganism is the activation and clonal expansion of antigen-reactive B lymphocytes ...
openaire +2 more sources
Purification of Monoclonal Antibodies
Current Protocols in Molecular Biology, 1997AbstractThe uses of monoclonal antibodies as enzyme conjugates and as immunoaffinity reagents require their purification from the crude ascites fluid. This unit provides protocols for purification using protein A‐Sepharose chromatography and affinity chromatography, which are superior to ammonium sulfate precipitation, gel filtration, or ion‐exchange ...
S A, Fuller, M, Takahashi, J G, Hurrell
openaire +2 more sources
Monoclonal Antibodies to Benzodiazepines
Journal of Neurochemistry, 1985Abstract: Four hybridoma lines secreting monoclonal antibodies to benzodiazepines were produced after BALB/c mice were immunized with a benzodiazepine‐bovine serum albumin conjugate. The monoclonal antibodies were purified from ascites fluids, and their binding affinities for benzodiazepines and other benzodiazepine receptor ligands were determined ...
A L, De Blas +5 more
openaire +2 more sources
Radiolabeling of Monoclonal Antibodies
2000Radiolabeling of monoclonal antibodies (mAbs) is often one of the principal methods for the in vitro and in vivo assessment of these reagents, whether this is determining the affinity of a new reagent, preparing for preclinical testing, or clinically for diagnostic or therapeutic use.
openaire +2 more sources
Therapy with Monoclonal Antibodies
Drug Intelligence & Clinical Pharmacy, 1984Monoclonal antibodies (MABs) are an exciting development in the field of clinical immunology. Secreted in large amounts from hybrid myeloma (hybridoma) cell lines, MABs are directed at a specific antigen, such as tumor cell antigens, providing a major advantage over conventional, heterogeneous antisera.
openaire +2 more sources