Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic therapeutic [PDF]
, 2015 Herein we present a significant step towards next-generation antibody-based photodynamic therapeutics. Site-selective modification of a clinically relevant monoclonal antibody, with a serum-stable linker bearing a strained alkyne, allows for the ...
Boyle, Ross +5 more
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A high-affinity antibody against the CSP N-terminal domain lacks Plasmodium falciparum inhibitory activity [PDF]
, 2020 Malaria is a global health concern and research efforts are ongoing to develop a superior vaccine to RTS,S/AS01. To guide immunogen design, we seek a comprehensive understanding of the protective humoral response against Plasmodium falciparum ...
Bosch, A. +15 more
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Antibody binding reports spatial heterogeneities in cell membrane organization [PDF]
, 2022 The spatial organization of cell membrane glycoproteins and glycolipids is critical for mediating the binding of ligands, receptors, and macromolecules on the plasma membrane. However, we currently do not have the methods to quantify the spatial heterogeneities of macromolecular crowding on live cell surfaces.
arxiv +1 more source
New England Journal of Medicine, 2001 BACKGROUND The HER2 gene, which encodes the growth factor receptor HER2, is amplified and HER2 is overexpressed in 25 to 30 percent of breast cancers, increasing the aggressiveness of the tumor.
D. Slamon +11 more
semanticscholar +1 more source
Establishment of a monoclonal antibody for human LXRα: Detection of LXRα protein expression in human macrophages [PDF]
, 2003 Liver X activated receptor alpha (LXRα) forms a functional dimeric nuclear receptor with RXR that regulates the metabolism of several important lipids, including cholesterol and bile acids.
Hamakubo, Takao +12 more
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Journal of Immunology, 1984 The monoclonal antibody Ki-67 detects a nuclear antigen that is present only in proliferating cells. The aim of the present investigation was to clarify whether the Ki-67 nuclear antigen is restricted in its expression to certain phases of the cell cycle.
J. Gerdes +5 more
semanticscholar +1 more source
Antibody Conjugation and Formulation [PDF]
, 2019 In an era where ultra-high antibody concentrations, high viscosities, low volumes, auto-injectors, and long storage requirements are already complex problems with the current unconjugated monoclonal antibodies on the market the formulation demands for ...
Alves, Nathan J.
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Reduced tubulin tyrosination as an early marker of mercury toxicity in differentiating N2a cells [PDF]
, 2007 The aims of this work were to compare the effects of methyl mercury chloride and Thimerosal on neurite/process outgrowth and microtubule proteins in differentiating mouse N2a neuroblastoma and rat C6 glioma cells.
A.J. Hargreaves +29 more
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Species- and organ-specificity of secretory proteins derived from human prostate and seminal vesicles [PDF]
, 1990 Polyclonal antibodies against semenogelin (SG) isolated from human seminal vesicle secretion and acid phosphatase (PAP), β‐microseminoprotein (β‐MSP), and Prostate‐Specific Antigen (PSA) derived from human prostatic fluid, as well as a monoclonal ...
Abrahamsson, P. +5 more
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Use of OKT3 with ciclosporin and steroids for reversal of acute kidney and liver allograft rejection [PDF]
, 1987 OKT3 monoclonal antibody therapy was added to preexisting baseline immunosuppressive treatment with ciclosporin and steroids to treat rejection in 52 recipients of cadaveric livers and 10 recipients of cadaveric kidneys.
Demetris, AJ, Fung, JJ, Porter, KA
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