Results 11 to 20 of about 2,663,866 (389)

A human monoclonal antibody blocking SARS-CoV-2 infection

Nature Communications, 2020
The emergence of the novel human coronavirus SARS-CoV-2 in Wuhan, China has caused a worldwide epidemic of respiratory disease (COVID-19). Vaccines and targeted therapeutics for treatment of this disease are currently lacking.
Chunyan Wang, Wentao Li, D. Drabek, Nisreen M. A. Okba, R. van Haperen, A. Osterhaus, F. V. van Kuppeveld, B. Haagmans, F. Grosveld, B. Bosch   +9 more
semanticscholar   +1 more source

Development of a triple antibody sandwich enzyme-linked immunosorbent assay for cassava mosaic disease detection using a monoclonal antibody to Sri Lankan cassava mosaic virus

Virology Journal, 2021
Background Cassava mosaic disease (CMD) is one of the most devastating viral diseases for cassava production in Africa and Asia. Accurate yet affordable diagnostics are one of the fundamental tools supporting successful CMD management, especially in ...
Saengsoon Charoenvilaisiri, Channarong Seepiban, Mallika Kumpoosiri, Sombat Rukpratanporn, Nuchnard Warin, Bencharong Phuangrat, Phakamat Chitchuea, Sirima Siripaitoon, Orawan Chatchawankanphanich, Oraprapai Gajanandana   +9 more
doaj   +1 more source

Monoclonal Antibodies for Bacterial Pathogens: Mechanisms of Action and Engineering Approaches for Enhanced Effector Functions

Biomedicines, 2022
Monoclonal antibody (mAb) therapy has opened a new era in the pharmaceutical field, finding application in various areas of research, from cancer to infectious diseases.
Fabiola Vacca, Claudia Sala, Rino Rappuoli   +2 more
doaj   +1 more source

B cell analyses after SARS-CoV-2 mRNA third vaccination reveals a hybrid immunity like antibody response

Nature Communications, 2023
SARS-CoV-2 vaccines and infection induce antibody responses but the evolution of subsequent variants has resulted in the development of escape mutants.
Emanuele Andreano, Ida Paciello, Giulio Pierleoni, Giulia Piccini, Valentina Abbiento, Giada Antonelli, Piero Pileri, Noemi Manganaro, Elisa Pantano, Giuseppe Maccari, Silvia Marchese, Lorena Donnici, Linda Benincasa, Ginevra Giglioli, Margherita Leonardi, Concetta De Santi, Massimiliano Fabbiani, Ilaria Rancan, Mario Tumbarello, Francesca Montagnani, Claudia Sala, Duccio Medini, Raffaele De Francesco, Emanuele Montomoli, Rino Rappuoli   +24 more
doaj   +1 more source

Establishing a novel and sensitive assay for bioactivity determination of anti-CD25 antibodies

Heliyon, 2023
Anti-CD25 antibodies have been approved for renal transplantation and has been used prior to and during transplantation by the Food and Drug Administration (FDA).
Maoqin Duan, Chuanfei Yu, Yalan Yang, Zhihao Fu, Chunyu Liu, Jialiang Du, Meng Li, Sha Guo, XiaoJuan Yu, Gangling Xu, Yuting Mei, Lan Wang   +11 more
doaj   +1 more source

Method validation of a bridging immunoassay in combination with acid-dissociation and bead treatment for detection of anti-drug antibody

Heliyon, 2023
Anti-drug antibody (ADA) positivity is correlated with disease relapse risk when treated with monoclonal antibody (mAb) therapeutics. ADA evaluation can assist with interpreting pharmacokinetic, pharmacological, and toxicology results.
Jialiang Du, Yalan Yang, Lingling Zhu, Shaoyi Wang, Chuanfei Yu, Chunyu Liu, Caifeng Long, Baowen Chen, Gangling Xu, Linglong Zou, Lan Wang   +10 more
doaj   +1 more source

A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19

New England Journal of Medicine, 2020
Background LY-CoV555, a neutralizing monoclonal antibody, has been associated with a decrease in viral load and the frequency of hospitalizations or emergency department visits among outpatients with coronavirus disease 2019 (Covid-19).
J. Lundgren, B. Grund, Christina E. Barkauskas, T. Holland, R. Gottlieb, U. Sandkovsky, Samuel M. Brown, K. Knowlton, W. Self, D. Files, M. Jain, T. Benfield, M. Bowdish, B. Leshnower, J. Baker, J. Jensen, E. Gardner, A. Ginde, E. Harris, I. Johansen, N. Markowitz, M. Matthay, L. Østergaard, Christina C. Chang, V. Davey, Anna Goodman, E. Higgs, Daniel D. Murray, T. A. Murray, R. Paredes, Mahesh K B Parmar, A. Phillips, C. Reilly, Shweta Sharma, R. Dewar, M. Teitelbaum, D. Wentworth, H. Cao, P. Klekotka, A. Babiker, A. Gelijns, V. Kan, M. Polizzotto, B. Thompson, H. Lane, J. Neaton   +45 more
semanticscholar   +1 more source

A high-affinity antibody against the CSP N-terminal domain lacks Plasmodium falciparum inhibitory activity [PDF]

, 2020
Malaria is a global health concern and research efforts are ongoing to develop a superior vaccine to RTS,S/AS01. To guide immunogen design, we seek a comprehensive understanding of the protective humoral response against Plasmodium falciparum ...
Bosch, A., Costa, G., Flores-Garcia, Y., Julien, J., Levashina, E., Murugan, R., Oyen, D., Pholcharee, T., Prieto, K., Scally, S., Thai, E., Valleriani, A., Wardemann, H., Weyrich, A., Wilson, I., Wu, N.   +15 more
core   +2 more sources

Perspectives on monoclonal antibody therapy as potential therapeutic intervention for Coronavirus disease-19 (COVID-19).

Asian Pacific Journal of Allergy and Immunology, 2020
Last decade witnessed the outbreak of many life-threatening human pathogens including Nipah, Ebola, Chikungunya, Zika, Middle East respiratory syndrome coronavirus (MERS-CoV), Severe Acute respiratory syndrome coronavirus (SARS-CoV) and more recently ...
B. Shanmugaraj, K. Siriwattananon, K. Wangkanont, W. Phoolcharoen   +3 more
semanticscholar   +1 more source

Systematic comparison of monoclonal versus polyclonal antibodies for mapping histone modifications by ChIP-seq. [PDF]

, 2016
BackgroundThe robustness of ChIP-seq datasets is highly dependent upon the antibodies used. Currently, polyclonal antibodies are the standard despite several limitations: They are non-renewable, vary in performance between lots and need to be validated ...
Busby, Michele, Cornett, Evan M, Epstein, Charles B, Farjoun, Yossi, Gienger, Elizabeth, Gladden, Adrianne, Goren, Alon, Li, Catherine, Nusbaum, Chad, Rothbart, Scott B, Xue, Catherine, Yofe, Ido   +11 more
core   +1 more source