Results 61 to 70 of about 1,537,551 (243)
A colloid approach to self-assembling antibodies [PDF]
arXiv, 2018 Concentrated solutions of monoclonal antibodies have attracted considerable attention due to their importance in pharmaceutical formulations, yet their tendency to aggregate and the resulting high solution viscosity has posed considerable problems.
arxiv
Broad sarbecovirus neutralization by a human monoclonal antibody
Nature, 2021 M. A. Tortorici +45 more
semanticscholar +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background and Objectives Ofatumumab, a fully human anti‐CD20 monoclonal antibody, is effective in reducing relapses and disability progression in patients with multiple sclerosis. This study aimed to examine immune profile changes associated with ofatumumab in a prospective cohort of Chinese patients with relapsing–remitting multiple ...
Shu Yang +9 more
wiley +1 more source
Arthritis Care &Research, EarlyView.Objective Targeted synthetic disease‐modifying antirheumatic drugs (tsDMARDs) have expanded the management of autoimmune diseases, including rheumatic diseases. As the use of these drugs grows, it is important to understand their effects on pregnancy.
Vienna Cheng +7 more
wiley +1 more source
Mathematical Model of Colorectal Cancer with Monoclonal Antibody Treatments [PDF]
arXiv, 2013 We present a new mathematical model of colorectal cancer growth and its response to monoclonal-antibody (mAb) therapy. Although promising, most mAb drugs are still in trial phases, and the possible variations in the dosing schedules of those currently approved for use have not yet been thoroughly explored.
arxiv
Mucus Physically Restricts Influenza A Viral Particle Access to the Epithelium
Advanced Biology, EarlyView.The infectious potential of respiratory viruses depends on their ability to navigate through a layer of mucus that serves as a protective barrier in the lung. It is demonstrated that influenza A virus penetration through mucus is significantly limited by the gel's internal microstructure and, to a lesser extent, by adhesive binding to mucin glycans ...
Logan Kaler +8 more
wiley +1 more source
Energy-based generative models for monoclonal antibodies [PDF]
arXivSince the approval of the first antibody drug in 1986, a total of 162 antibodies have been approved for a wide range of therapeutic areas, including cancer, autoimmune, infectious, or cardiovascular diseases. Despite advances in biotechnology that accelerated the development of antibody drugs, the drug discovery process for this modality remains ...
arxiv
Monoclonal antibodies against rabies virus produced by somatic cell hybridization: detection of antigenic variants. [PDF]
, 1978 T. J. Wiktor, Hilary Koprowski
openalex +1 more source
Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis.
New England Journal of Medicine, 2012 BACKGROUND Type 17 helper T cells have been suggested to play a pathological role in psoriasis. They secrete several proinflammatory cytokines, including interleukin-17A (also known as interleukin-17).
C. Leonardi +7 more
semanticscholar +1 more source
Advanced Functional Materials, EarlyView.Surface‐attached multilayer micromagnet systems are fabricated by two‐photon crosslinking. The pillar‐shaped micro actuators consist of a soft and flexible surface‐attached cell‐repellent hydrogel layer at the bottom, acting as a hinge and a cell‐adhesive hydrophobic polymer filled with magnetic nanoparticles.
Nicolas Geid +5 more
wiley +1 more source