Results 11 to 20 of about 623,154 (347)

Kinetic Changes of Peripheral Blood Monocyte Subsets and Expression of Co-Stimulatory Molecules during Acute Dengue Virus Infection

Pathogens, 2021
Monocytes, one of the main target cells for dengue virus (DENV) infection, contribute to the resolution of viremia and to pathogenesis. We performed a longitudinal study by a detailed phenotypic comparison of classical (CD14++CD16−, non-classical (CD14 ...
Sakaorat Lertjuthaporn, Rassamon Keawvichit, Korakot Polsrila, Kasama Sukapirom, Ampaiwan Chuansumrit, Kulkanya Chokephaibulkit, Aftab A. Ansari, Ladawan Khowawisetsut, Kovit Pattanapanyasat   +8 more
doaj   +1 more source

The significance of macrophage polarization subtypes for animal models of tissue fibrosis and human fibrotic diseases. [PDF]

, 2015
The systemic and organ-specific human fibrotic disorders collectively represent one of the most serious health problems world-wide causing a large proportion of the total world population mortality.
Ballater R, Beon M, Bryan N, Butterfield TA, Connolly MK, Desmoulière A, Fallowfield JA, Galván‐Peña S, Gordon S, Goumans M, Hu B, Ito T, Jimenez SA, Korns D, Krieg T, Lassen S, Lech M, Leibovich SJ, Lev B, Mantovani A, Mantovani A, Molumdar K, Nestle FO, O’Doherty U, Piera‐Velazquez S, Poland GA, Rafii R, Rigamonte E, Tacke F, Venbervliet B, Wang Y, Wick G, Wijesundera KK   +32 more
core   +2 more sources

Synovial monocytes contribute to chronic inflammation in childhood-onset arthritis via IL-6/STAT signalling and cell-cell interactions

Frontiers in Immunology, 2023
IntroductionMonocytes are key effector cells in inflammatory processes. We and others have previously shown that synovial monocytes in childhood-onset arthritis are activated.
Tobias Schmidt, Tobias Schmidt, Alma Dahlberg, Alma Dahlberg, Elisabet Berthold, Petra Król, Petra Król, Sabine Arve-Butler, Sabine Arve-Butler, Emilia Rydén, Emilia Rydén, Seyed Morteza Najibi, Anki Mossberg, Anki Mossberg, Anders A. Bengtsson, Fredrik Kahn, Bengt Månsson, Robin Kahn, Robin Kahn   +18 more
doaj   +1 more source

Atherosusceptible Shear Stress Activates Endoplasmic Reticulum Stress to Promote Endothelial Inflammation. [PDF]

, 2017
Atherosclerosis impacts arteries where disturbed blood flow renders the endothelium susceptible to inflammation. Cytokine activation of endothelial cells (EC) upregulates VCAM-1 receptors that target monocyte recruitment to atherosusceptible regions ...
Bailey, Keith A, Haj, Fawaz G, Passerini, Anthony G, Simon, Scott I   +3 more
core   +1 more source

CCL17 Protects Against Viral Myocarditis by Suppressing the Recruitment of Regulatory T Cells

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Viral myocarditis is characterized by leukocyte infiltration of the heart and cardiomyocyte death. We recently identified C‐C chemokine ligand (CCL) 17 as a proinflammatory effector of C‐C chemokine receptor 2–positive macrophages and ...
Guoshuai Feng, Cuige Zhu, Chieh‐Yu Lin, Andrea Bredemeyer, Irmgard Förster, Daniel Kreisel, Kory J. Lavine   +6 more
doaj   +1 more source

Monocyte-endothelial cell interactions in vascular and tissue remodeling

Frontiers in Immunology, 2023
Monocytes are circulating leukocytes of innate immunity derived from the bone marrow that interact with endothelial cells under physiological or pathophysiological conditions to orchestrate inflammation, angiogenesis, or tissue remodeling.
Mireia Medrano-Bosch, Blanca Simón-Codina, Wladimiro Jiménez, Wladimiro Jiménez, Elazer R. Edelman, Pedro Melgar-Lesmes, Pedro Melgar-Lesmes, Pedro Melgar-Lesmes   +7 more
doaj   +1 more source

Intermediate Monocytes with PD-L1 and CD62L Expression as a Possible Player in Active SARS-CoV-2 Infection

Viruses, 2022
Monocytes play a role in viral biology, but little is known about the monocyte subpopulation in the course of COVID-19 disease. The aim of the study was the analysis of classical, intermediate and non-classical monocytes with expression of PD-L1 and ...
Elżbieta Rutkowska, Iwona Kwiecień, Krzysztof Kłos, Piotr Rzepecki, Andrzej Chciałowski   +4 more
doaj   +1 more source

Rab Geranylgeranyltransferase Subunit Beta as a Potential Indicator to Assess the Progression of Amyotrophic Lateral Sclerosis

Brain Sciences, 2023
Background: Currently, there is no effective treatment for amyotrophic lateral sclerosis (ALS), a devastating neurodegenerative disorder. Many biomarkers have been proposed, but because ALS is a clinically heterogeneous disease with an unclear etiology ...
Jing Yang, Cheng Xin, Jia Huo, Xin Li, Hui Dong, Qi Liu, Rui Li, Yaling Liu   +7 more
doaj   +1 more source

Platelets promote macrophage polarization toward pro-inflammatory phenotype and increase survival of septic mice [PDF]

, 2019
We investigated the contribution of human platelets to macrophage effector properties in the presence of lipopolysaccharide (LPS), as well as the beneficial effects and time frame for platelet transfusion in septic animals.
Carestia, Agostina, Carrera Silva, Eugenio Antonio, Errasti, Andrea Emilse, Gomez, Ricardo Martin, Jenne, Craig N., Mena, Hebe Agustina, Negrotto, Soledad, Olexen, Cinthia Mariel, Ortiz Wilczyñski, Juan Manuel, Schattner, Mirta Ana   +9 more
core   +1 more source

Causal relationship between circulating immune cells and the risk of type 2 diabetes: a Mendelian randomization study

Frontiers in Endocrinology, 2023
ObjectivesThough type 2 diabetes (T2D) has been known as a metabolic disease caused by multiple factors, the etiology remains insufficiently understood.
Jin Li, Qingmin Niu, Aiwei Wu, Yuchu Zhang, Liquan Hong, Hu Wang   +5 more
doaj   +1 more source