Results 31 to 40 of about 623,154 (347)

Monocyte subsets, stanford-A acute aortic dissection, and carotid srtery stenosis. new evidences [PDF]

, 2019
Monocytes are a heterogeneous cell population distinguished into three subsets with distinctive phenotypic and functional properties: "classical" (CD14++CD16-), "intermediate" (CD14++CD16+), and "nonclassical" (CD14+CD16++).
Cifani, Noemi, Del Porto, Flavia, Proietta, Maria, Taurino, Maurizio, Tritapepe, Luigi   +4 more
core   +1 more source

DENDRITIC CELL DIFFERENTIATION BLOCKED BY PRIMARY EFFUSION LYMPHOMA-RELEASED FACTORS IS PARTIALLY RESTORED BY INHIBITION OF P38 MAPK [PDF]

, 2010
To better understand the molecular mechanisms underlying the dendritic cell (DC) defects in cancer, we analyzed which signaling pathway is implicated in the abnormal monocyte differentiation into DC determined by the presence of Primary effusion lymphoma
CIRONE, Mara, DI RENZO, Livia Maria, FAGGIONI, Alberto, FRATI, Luigi, G. Borgia, G. Lucania, TRIVEDI, PANKAJ   +6 more
core   +2 more sources

Targeting Histone Deacetylases in Myeloid Cells Inhibits Their Maturation and Inflammatory Function With Limited Effects on Atherosclerosis

Frontiers in Pharmacology, 2019
Monocytes and macrophages are key drivers in the pathogenesis of inflammatory diseases. Epigenetic targets have been shown to control the transcriptional profile and phenotype of these cells.
Rosario Luque-Martin, Jan Van den Bossche, Rebecca C. Furze, Annette E. Neele, Saskia van der Velden, Marion J.J. Gijbels, Marion J.J. Gijbels, Cindy P.P.A. van Roomen, Sharon G. Bernard, Wouter J. de Jonge, Inmaculada Rioja, Rab K. Prinjha, Huw D. Lewis, Palwinder K. Mander, Menno P.J. de Winther, Menno P.J. de Winther   +15 more
doaj   +1 more source

PRAS40 suppresses atherogenesis through inhibition of mTORC1-dependent pro-inflammatory signaling in endothelial cells [PDF]

, 2019
Endothelial pro-inflammatory activation plays a pivotal role in atherosclerosis, and many pro-inflammatory and atherogenic signals converge upon mechanistic target of rapamycin (mTOR).
Althoff, Till F., Burghaus, Jana, Cao Ho, Thanh, Jürgensen, Lonny, Kamuf-Schenk, Verena, Katus, Hugo A., Kiper, Leon, Krull, Alexandros, Riechert, Eva, Schecker, Johannes, Stangl, Karl, Stangl, Verena, Völkers, Mirko, Wöltje, Kerstin, Zhang, Kevin Sun   +14 more
core   +1 more source

Causes and Consequences of Innate Immune Dysfunction in Cirrhosis

Frontiers in Immunology, 2019
Liver cirrhosis is an increasing health burden and public health concern. Regardless of etiology, patients with cirrhosis are at risk of a range of life-threatening complications, including the development of infections, which are associated with high ...
Katharine Margaret Irvine, Isanka Ratnasekera, Elizabeth E. Powell, Elizabeth E. Powell, David Arthur Hume   +4 more
doaj   +1 more source

Angiotensin type-2 (AT-2)-receptor activation reduces renal fibrosis in cyclosporine nephropathy: evidence for blood-pressure independent effect [PDF]

, 2016
Compound 21 (C21), selective agonist of AT2 receptors, shows antinflammatory effects in hypertension and nephroprotection in diabetes. The aim of this study was to evaluate the effects of C21 in cyclosporine nephropathy, which is characterized mainly by ...
Carletti, R, Castoldi, G, DI GIOIA, Cira Rosaria Tiziana, Roma, F, Stella, A., Zerbini, G   +5 more
core   +1 more source

The single-nucleotide polymorphism (GPX4c718t) in the glutathione peroxidase 4 gene influences endothelial cell function : Interaction with selenium and fatty acids [PDF]

, 2013
© 2013 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH Verlag GmbH & Co.
Akbaraly, Bellinger, Bermano, Bermano, Björnstedt, Brigelius-Flohé, Brigelius-Flohé, Drummen, Gautrey, Gong, Gu, Hayden, Hesketh, Kretz-Remy, Libby, Lubos, Mata, Mayer, Miller, Mozaffarian, Méplan, Phillips, Polonikov, Rayman, Sneddon, Sneddon, Sneddon, Sutherland, Thies, To, Udler, Villette   +31 more
core   +2 more sources

The Leukocyte Subtype Counts and Ratios Can Effectively Predict the Risk of Arterial Stiffness Assessed by Cardio-Ankle Vascular Index: A Retrospective Study

Frontiers in Cardiovascular Medicine, 2021
Background: Arterial stiffness was the pathological basis and risk factor of cardiovascular diseases, with chronic inflammation as the core characteristic.
Yaoling Wang, Ruiyun Wang, Lijuan Bai, Yun Liu, Lihua Liu, Linfeng He, Benling Qi   +6 more
doaj   +1 more source

Tauroursodeoxycholic acid regulates macrophage/monocyte distribution and improves spinal microenvironment to promote nerve regeneration through inhibiting NF-κB signaling pathway in spinal cord injury

Frontiers in Pharmacology
IntroductionFollowing spinal cord injury (SCI), blood-borne monocytes infiltrate the spinal cord, differentiate into macrophages, and dominate the lesion site.
Yonghui Hou, Yonghui Hou, Yage Zhang, Yage Zhang, Lin Ma, Lin Ma, Dan Luo, Dan Luo, Wanshun Wang, Wanshun Wang, Shunmei E., Chengxi Huang, Yu Hou, Yu Hou, Shudong Chen, Shudong Chen, Jiheng Zhan, Jiheng Zhan, Liangliang Xu, Liangliang Xu, Dingkun Lin, Dingkun Lin   +21 more
doaj   +1 more source

Single Cell RNA-Seq and Machine Learning Reveal Novel Subpopulations in Low-Grade Inflammatory Monocytes With Unique Regulatory Circuits

Frontiers in Immunology, 2021
Subclinical doses of LPS (SD-LPS) are known to cause low-grade inflammatory activation of monocytes, which could lead to inflammatory diseases including atherosclerosis and metabolic syndrome.
Jiyoung Lee, Jiyoung Lee, Shuo Geng, Song Li, Song Li, Liwu Li   +5 more
doaj   +1 more source