Results 31 to 40 of about 314,823 (249)

Comparative Analysis of Long Non-Coding RNA Expression and Immune Response in Mild and Severe COVID-19

Frontiers in Molecular Biosciences, 2022
Background: Coronavirus disease 2019 (COVID-19) is a worldwide emergency, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Long non-coding RNAs (lncRNAs) do not encode proteins but could participate in immune response.Methods: In ...
Yongting Zhang, Fan Shi, Yuchong Wang, Yuting Meng, Qiong Zhang, Kaihang Wang, Ping Zeng, Hongyan Diao   +7 more
doaj   +1 more source

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

高海拔地区缺血性卒中患者单核 细胞/HDL-C比值与脑动脉粥样硬化性狭窄的相关性 LEI Yancheng, LIU Zhu, WANG Jinpeng, ZHANG Hao, YANG Wenfang, XIAO Shunxi, YANG Huijie, MO Haizhen, CHEN Yan

Zhongguo cuzhong zazhi, 2022
目的 研究高海拔地区缺血性卒中患者单核细胞/HDL-C比值（monocyte/HDL-C ratio，MHR）与颅内动脉粥样硬化性狭窄（intracranial atherosclerotic stenosis，ICSA）程度的相关性。 方法 回顾性连续纳入2017年6月-2021年6月在青海省人民医院住院治疗的高海拔地区（海拔2260～4080 m）的急性缺血性卒中患者，依据DSA上脑血管狭窄程度（以狭窄最严重的动脉为准）分为无狭窄组、轻度狭窄（狭窄率≤50%）组、中度狭窄（狭窄率50%～70%）组、
雷延成, 刘著, 王进鹏, 张豪, 杨文芳, 肖顺熙, 杨慧洁, 莫海珍, 陈燕
doaj   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

In Vitro Exposure of Primary Human T Cells and Monocytes to Polyclonal Stimuli Reveals a Basal Susceptibility to Display an Impaired Cellular Immune Response and Develop Severe COVID-19

Frontiers in Immunology, 2022
The contribution of the cellular immune response to the severity of coronavirus disease 2019 (COVID-19) is still uncertain because most evidence comes from patients receiving multiple drugs able to change immune function.
Rebeca Viurcos-Sanabria, Rebeca Viurcos-Sanabria, Aarón N. Manjarrez-Reyna, Helena Solleiro-Villavicencio, Salma A. Rizo-Téllez, Salma A. Rizo-Téllez, Lucía A. Méndez-García, Victoria Viurcos-Sanabria, Jacquelina González-Sanabria, América Arroyo-Valerio, José D. Carrillo-Ruíz, José D. Carrillo-Ruíz, José D. Carrillo-Ruíz, Antonio González-Chávez, Jose I. León-Pedroza, Jose I. León-Pedroza, Jose I. León-Pedroza, Raúl Flores-Mejía, Octavio Rodríguez-Cortés, Galileo Escobedo   +19 more
doaj   +1 more source

A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.
Volga M Saini, Ezgi Oner, Mark P. Ward, Sinead Hurley, Brian David Henderson, Faye Lewis, Stephen P. Finn, Gerard J. Fitzmaurice, John J. O'Leary, Sharon O'Toole, Lorraine O'Driscoll, Kathy Gately   +11 more
wiley   +1 more source

Targeting Histone Deacetylases in Myeloid Cells Inhibits Their Maturation and Inflammatory Function With Limited Effects on Atherosclerosis

Frontiers in Pharmacology, 2019
Monocytes and macrophages are key drivers in the pathogenesis of inflammatory diseases. Epigenetic targets have been shown to control the transcriptional profile and phenotype of these cells.
Rosario Luque-Martin, Jan Van den Bossche, Rebecca C. Furze, Annette E. Neele, Saskia van der Velden, Marion J.J. Gijbels, Marion J.J. Gijbels, Cindy P.P.A. van Roomen, Sharon G. Bernard, Wouter J. de Jonge, Inmaculada Rioja, Rab K. Prinjha, Huw D. Lewis, Palwinder K. Mander, Menno P.J. de Winther, Menno P.J. de Winther   +15 more
doaj   +1 more source

Analysis of chromatin data supports a role for CD14+ monocytes/macrophages in mediating genetic risk for juvenile idiopathic arthritis

Frontiers in Immunology, 2022
IntroductionGenome wide association studies (GWAS) have identified multiple regions that confer genetic risk for the polyarticular/oligoarticular forms of juvenile idiopathic arthritis (JIA).
Elizabeth A. Crinzi, Emma K. Haley, Kerry E. Poppenberg, Kerry E. Poppenberg, Kaiyu Jiang, Vincent M. Tutino, Vincent M. Tutino, James N. Jarvis, James N. Jarvis   +8 more
doaj   +1 more source

The accumulation of myeloid‐derived suppressor cells participates in abdominal infection‐induced tumor progression through the PD‐L1/PD‐1 axis

Molecular Oncology, EarlyView.
This study explores how sepsis affects GC progression by creating an immunosuppressive environment. Our findings reveal that sepsis promotes immune dysregulation, enhancing tumor growth and metastasis. Targeting the PD‐1/PD‐L1 pathway with monoclonal antibodies shows potential for restoring immune function and improving outcomes in cancer patients ...
Yiding Wang, Ting Guo, Xiaofang Xing, Xijuan Liu, Xuejun Gan, Yingai Li, Yan Liu, Fei Shan, Zhouqiao Wu, Jiafu Ji, Ziyu Li   +10 more
wiley   +1 more source