Results 271 to 280 of about 130,905 (336)

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source

Endothelial GPR68 Is Essential for Arteriogenesis and Represents a Therapeutic Target in a Model of Peripheral Artery Disease

Advanced Science, Volume 13, Issue 31, 4 June 2026.
Endothelial GPR68 is identified as a critical regulator of collateral artery growth in peripheral artery disease. Genetic and pharmacological evidence demonstrates that GPR68 integrates hemodynamic cues to drive monocyte recruitment and inflammatory remodeling, thereby promoting collateral arteriogenesis and tissue perfusion after ischemia ...
Yiyan Song, Senyi Peng, Zhilei Huang, Miao Yu, Mingyue Wu, Yuexin Zhu, Zeyi Zhou, Yongshan Liu, Yalin Zhang, Yu Huang, Zhongxing Wang, Fu‐Li Xiang, Jie Xu   +12 more
wiley   +1 more source

Neurocognitive Aging Following Acute Illness: Pathobiology and a Framework for Developing Neurotherapeutic Agents

Brain and Behavior, Volume 16, Issue 6, June 2026.
In this review, we discuss the scientific basis for how neurocognitive aging occurs after critical illness, including sepsis, trauma, and burns, and the clinical need to develop therapies to reduce inflammation, protect the blood–brain barrier, remove senescent cells, and enhance neuroplasticity.
Errin Lawrence, Daniel Fulton, Poppy Brown, Subashini Suresh, Mark Morris, Paraskevi Goggolidou, Sree Chaithanya, Marcus Abbawy, Amelia Wild, Prashant Nasa, Niharika A. Duggal, Fang Gao‐Smith, Zubair Ahmed, Suresh Renukappa, Tonny Veenith   +14 more
wiley   +1 more source

Predicting chemotherapy toxicity in multiple myeloma: the prognostic value of pre-treatment serum cytokine levels of interleukin-6, interleukin-8, monocyte chemoattractant protein-1, and vascular endothelial growth factor. [PDF]

Front Immunol
Mielnik M, Podgajna-Mielnik M, Szudy-Szczyrek A, Homa-Mlak I, Mlak R, Gorący A, Hus M.   +6 more
europepmc   +1 more source

Improvement of Mixed Inflammatory Environment in Nasal Secretions of Diffuse Type 2 Chronic Rhinosinusitis With Nasal Polyps Under Dupilumab

Clinical and Translational Allergy, Volume 16, Issue 6, June 2026.
ABSTRACT Background In Western countries, Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) is predominantly associated with a type 2 inflammatory endotype. While nasal secretion analysis shows promise for disease endotyping, current biomarkers remain limited for accurate stratification, disease monitoring, and prediction of treatment response ...
Fabio S. Ryser, Tina Mauthe, Catrin Brühlmann, Michael B. Soyka, Urs C. Steiner   +4 more
wiley   +1 more source

Nanoparticles in Vascular Dementia: Advantages and Challenges

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
This review highlights the dual diagnostic and therapeutic potential of nanomaterials in Vascular Dementia (VaD). By effectively crossing the blood–brain barrier, functionalized nanoparticles facilitate early diagnosis by targeting Aβ deposits and vascular lesions.
Xianxin Liu, JiaLi Hu, Yueming qiu, Huaying Wang, Chunxiao Shen, Ziying Liu, Yiting He, Xuefei Du, Xiaorong Zhang   +8 more
wiley   +1 more source

Extracellular Vesicles as Drivers of Lung Endothelial Dysfunction in ARDS: Mechanisms and Therapeutic Opportunities

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
This review summarizes how extracellular vesicles from diverse pulmonary and extrapulmonary sources contribute to endothelial dysfunction in ARDS and evaluates emerging endothelial‐targeted therapies for their potential to mitigate EV‐mediated pathogenic mechanisms.
Mohammed Yaman Al Matni, Patrick Belvitch, Steven M. Dudek, Eleftheria Letsiou   +3 more
wiley   +1 more source

Sensing and Communicating β‐Cell Stress in the Context of T1D Etiology: New Opportunities for Therapeutic Impact

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
Type 1 diabetes (T1D) results from the immune‐mediated destruction of insulin‐producing pancreatic β‐cells. Recent human studies show that early β‐cell stress maladaptations precede overt immune cell infiltration. DOC2B, a vesicle secretion regulatory protein that supports β‐cell functionality and resilience against stress, declines early in T1D ...
Diana Esparza, Chathurani S. Jayasena, Tijana Jovanovic‐Talisman, Debbie C. Thurmond   +3 more
wiley   +1 more source