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The regulation and importance of monocyte chemoattractant protein-1
Current Opinion in Hematology, 2018Purpose of review Monocyte chemoattractant protein (MCP)-1, a chemokine regulating monocyte chemotaxis and T-lymphocyte differentiation by binding to the CC chemokine receptor 2 (CCR2), plays a crucial role in the pathogenesis of inflammatory diseases, atherosclerosis and cancer.
V. Bianconi +3 more
semanticscholar +3 more sources
Monocyte chemoattractant protein-1 and the kidney
Current Opinion in Nephrology and Hypertension, 2016Recently, initial studies have been carried out in patients using monocyte chemoattractant protein-1 (MCP-1) inhibitors. This review summarizes the known function of MCP-1 in regulating monocytes during inflammation and its role in inflammatory disease of the kidney.MCP-1 is one of the first chemokines described and plays an important role in renal ...
H. Haller +3 more
semanticscholar +3 more sources
Curcumin as a natural regulator of monocyte chemoattractant protein-1.
Cytokine & Growth Factor Reviews, 2017Monocyte chemoattractant/chemotactic protein-1 (MCP-1), a member of the CC chemokine family, is one of the key chemokines that regulate migration and tissue infiltration of monocytes/macrophages. Its role in the pathophysiology of several inflammatory diseases has been widely recognized, thus making MCP-1 a possible target for anti-inflammatory ...
M. Karimian +3 more
semanticscholar +3 more sources
Human monocyte chemoattractant protein-1 (MCP-1).
Immunology Today, 1990During the past three years great advances have been made in the chemistry and biology of chemoattractants for human leukocytes. Two chemoattractant cytokines have been isolated, sequenced and cloned, each with distinctive leukocyte attractant specificity.
E. Leonard, T. Yoshimura
semanticscholar +4 more sources
Human Pathology, 1993
The infiltration of blood monocytes into the subendothelial space is thought to be one of the most important pathologic events in early atherogenesis. To examine the mechanism of monocyte migration in early atherosclerotic lesions we investigated immunohistochemically the production of monocyte chemoattractant protein-1 (MCP-1) in various ...
Motohiro Takeya +2 more
exaly +3 more sources
The infiltration of blood monocytes into the subendothelial space is thought to be one of the most important pathologic events in early atherogenesis. To examine the mechanism of monocyte migration in early atherosclerotic lesions we investigated immunohistochemically the production of monocyte chemoattractant protein-1 (MCP-1) in various ...
Motohiro Takeya +2 more
exaly +3 more sources
The role of monocyte chemoattractant protein-1 in biliary atresia
Journal of Pediatric Surgery, 2006The aim of this study was to explain the role of monocyte chemoattractant protein-1 (MCP-1) in biliary atresia (BA).Concentrations of serum MCP-1 and collagen type IV were measured in 38 patients with BA by using commercially available kits. MCP-1 was also assessed in liver biopsy specimens by using immunohistochemistry.
Takuya Tamatani +2 more
exaly +3 more sources
Production of monocyte chemoattractant protein‐1 in amyotrophic lateral sclerosis
Muscle & Nerve, 2005 AbstractThe presence of activated microglia in the spinal cord of amyotrophic lateral sclerosis (ALS) patients is usually accompanied by inflammatory biochemical changes, but these are largely unexplored. Monocyte chemoattractant protein‐1 (MCP‐1) is critical for recruitment of inflammatory cells of monocytic lineage after inflammation or injury to the
P. L. Baron +10 more
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FEBS Letters, 1999 The chemokine monocyte chemoattractant protein-1 is a potent chemoattractant for monocytes. Monocyte chemoattractant protein-1 is produced by vascular endothelial cells during inflammatory diseases such as atherosclerosis.
Koji Murao +2 more
exaly +2 more sources
Monocyte chemoattractant protein-1 and hypertension: An overview
Hipertensión y Riesgo Vascular, 2022The association between hypertension and cardiovascular disease (CVD) has been increasingly studied through early inflammatory biomarkers. The monocyte chemoattractant protein-1 (MCP-1) is the main chemokine implicated in the inflammatory endothelial process, attracting monocytes and macrophages to the atherosclerotic plaque.We reviewed the main ...
A, Cortez, E, Muxfeldt
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