Results 61 to 70 of about 32,111,831 (291)

Triptolide down-regulates tumor necrosis factor-α and interferon-γ-induced overexpression of monocyte chemoattractant protein-1 in human proximal tubular epithelial cells [PDF]

, 2002
ObjectiveTriptolide is the major active component of Tripterygium wilfordii Hook. f., which has been used as an anti-inflammatory agent in traditional Chinese medicine for centuries.
LIU, Dong, DAI, Chun-Sun, LI, Lei-Shi, LIU, Zhi-Hong, LI, Heng   +4 more
core   +1 more source

BCG HSP70 Reprograms Macrophages via Central Trained Immunity to Suppress Prostate Cancer

Advanced Science, EarlyView.
BCG‐derived HSP70 (Dnak) safely induces central trained immunity via epigenetic, metabolic, and O‐GlcNAcylation reprogramming of bone marrow progenitors, driving tumor‐associated macrophages toward an M1‐like phenotype to suppress prostate cancer. ABSTRACT Trained immunity offers a promising yet clinically challenging strategy for cancer immunotherapy,
Peng Liu, Kangkang Liu, Keruo Wang, Heyang Guan, Jiaming Fan, Taipeng Li, Jiaru Hao, Zeyuan Wang, Yongchao Yan, Jiatong Chen, Yuan Ma, Yang Yang, Yuanjie Niu   +12 more
wiley   +1 more source

Investigation of monocyte chemoattractant protein-1 (MCP-1) [PDF]

, 1991
Thesis (D.Sc.D.)--Boston University, Henry M. Goldman School of Graduate Dentistry (Oral Biology)Includes bibliography (leaves 54-66)Mononuclear phagocytes play a critical role in defending the host against foreign organisms and in regulating the ...
Jiang, Yanling
core   +1 more source

Role of Monocyte Chemoattractant Protein-1 in Myocardial Infarction

International Journal of Biomedical Science, 2007
Myocardial infarction (MI) is accompanied by inflammatory responses that lead to the recruitment of leukocytes and subsequent myocardial damage, healing, and scar formation. Chemokines are a family of potent chemoattractant cytokines that regulate the leukocyte trafficking in basal levels and inflammatory processes; however, it has been recently ...
Hajime, Morimoto, Masafumi, Takahashi
openaire   +2 more sources

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Differential expression of macrophage inflammatory protein-2 and monocyte chemoattractant protein-1 in experimental glomerulonephritis [PDF]

, 1996
Differential expression of macrophage inflammatory protein-2 and monocyte chemoattractant protein-1 in experimental glomerulonephritis. We examined the relation between glomerular expression of chemokines from α-subfamily (macrophage inflammatory protein-
Jennifer Smith, Rees, Andrew J., Steinkasserer, Alexander, Klaus Langner, Teizo Yoshimura, Frederick W.K. Tam, Yoshimura, Teizo, Roland Kurrle, Karkar, Ayman M., Ayman M. Karkar, Tam, Frederick W.K., Langner, Klaus, Andrew J. Rees, Smith, Jennifer, Alexander Steinkasserer, Kurrle, Roland   +15 more
core   +1 more source

Single‐Dose TACE‐Like Injection of Sustained‐Release Panobinostat/IL‐12 Polymeric Microparticles is Effective in Preclinical Liver Cancer Models

Advanced Science, EarlyView.
A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu, Ling Li, Sachin S. Surwase, Xin Ming M. Zhou, Hongtao Qian, Joel C. Sunshine, Florin M. Selaru, Jordan J. Green   +7 more
wiley   +1 more source

Monocyte Chemoattractant Protein 1 is a Prognostic Marker in ANCA-Associated Small Vessel Vasculitis

Mediators of Inflammation, 2009
Background. The (anti neutrophil cytoplasmatic autoantibody ANCA), associated small vessel vasculitides (ASVV) are relapsing-remitting inflammatory disorders, involving various organs, such as the kidneys.
Sophie Ohlsson, Omran Bakoush, Jan Tencer, Ole Torffvit, Mårten Segelmark   +4 more
doaj   +1 more source

Endogenous monocyte chemoattractant protein-1 recruits monocytes in the zymosan peritonitis model [PDF]

Journal of Leukocyte Biology, 1998
Abstract The role of monocyte chemoattractant protein-1 (MCP-1) in the recruitment of blood-derived monocytes in a model of zymosan peritoneal inflammation was investigated. After zymosan injection (1 mg) a rapid influx of polymorphonuclear leukocytes (PMN) and monocytes into the peritoneal cavity associated with mouse MCP-1 (JE) gene ...
M N, Ajuebor, R J, Flower, R, Hannon, M, Christie, K, Bowers, A, Verity, M, Perretti   +6 more
openaire   +2 more sources

Identifying chemokines as therapeutic targets in renal disease: Lessons from antagonist studies and knockout mice [PDF]

, 2004
Chemokines, in concert with cytokines and adhesion molecules, play multiple roles in local and systemic immune responses. In the kidney, the temporal and spatial expression of chemokines correlates with local renal damage and accumulation of chemokine ...
Anders, Hans-Joachim, Vielhauer, Volker, Eis, Vaclav, Schlöndorff, Detlef   +3 more
core   +1 more source