Results 91 to 100 of about 176,233 (276)

Image_5_Increased Monocyte-Derived CD11b+ Macrophage Subpopulations Following Cigarette Smoke Exposure Are Associated With Impaired Bleomycin-Induced Tissue Remodelling.tif

, 2021
RationaleThe accumulation of macrophages in the airways and the pulmonary interstitium is a hallmark of cigarette smoke-associated inflammation. Notably, pulmonary macrophages are not a homogenous population but consist of several subpopulations. To date,
Martin R. Stämpfli (11440042), Danya Thayaparan (10173586), Christopher S. Stevenson (10173588), Peiyao Wang (4116649), Matthew F. Fantauzzi (11440033), Spencer D. Revill (11440030), Steven P. Cass (11440021), Fernando M. Botelho (7368626), Kjetil Ask (91350), Joshua J. C. McGrath (11440027), Amir Reihani (11440036), Anna Dvorkin-Gheva (201099), Olivia Mekhael (11440024), Aaron I. Hayat (11440039)   +13 more
core   +1 more source

The dysregulation of monocyte subpopulations in individuals at risk of developing rheumatoid arthritis

Rheumatology, 2020
Abstract Objectives Individuals carrying antibodies against citrullinated proteins (ACPA) are at high risk of developing RA. EULAR provided a clinical definition of individuals with arthralgia suspicious for progression to RA (clinically suspect arthralgia, CSA).
Klára Prajzlerová, Olga Kryštůfková, Martin Komarc, Heřman Mann, Hana Hulejová, Nora Petrovská, Monika Gregová, Petra Hánová, Karel Pavelka, Jiří Vencovský, Ladislav Šenolt, Mária Filková   +11 more
openaire   +2 more sources

Differential chemokine receptor expression and function in human monocyte subpopulations [PDF]

Journal of Leukocyte Biology, 2000
Abstract The subset of human blood monocytes expressing low levels of CD14 and high levels of CD16 (CD14+CD16+) exhibits features resembling mature tissue macrophages and can be expanded in inflammatory conditions. We analyzed expression of CC chemokine receptors (CCR) in CD14+CD16+ versus CD14++ monocytes, which may be crucial for ...
C, Weber, K U, Belge, P, von Hundelshausen, G, Draude, B, Steppich, M, Mack, M, Frankenberger, K S, Weber, H W, Ziegler-Heitbrock   +8 more
openaire   +2 more sources

Chiral Nanoparticles Suppress Inflammatory Infiltration to Promote Extracellular Matrix Remodeling for Ectopia Lentis Therapy

Advanced Science, EarlyView.
L‐cysteine‐configured chiral polyurethane nanoparticles suppress ocular inflammation and reduce extracellular matrix (ECM) degradation in ectopia lentis by regulating macrophages polarization and inhibiting nuclear factor kappa B signaling pathway. By promoting zonular fiber‐associated protein restoration and tissue repair, this minimally invasive ...
Yinuo Wen, Yan Yang, Haihan Gao, Yan Liu, Xinyue Wang, Linghao Song, Ruohong Li, Ao Miao, Jie Xu, Zhennan Zhao, Dan Li, Shenjie Peng, Linzhao Li, Min Zhang, Yonghang Liu, Liren Wang, Tianhui Chen, Yongxiang Jiang   +17 more
wiley   +1 more source

Image_1_Increased Monocyte-Derived CD11b+ Macrophage Subpopulations Following Cigarette Smoke Exposure Are Associated With Impaired Bleomycin-Induced Tissue Remodelling.tif

, 2021
RationaleThe accumulation of macrophages in the airways and the pulmonary interstitium is a hallmark of cigarette smoke-associated inflammation. Notably, pulmonary macrophages are not a homogenous population but consist of several subpopulations. To date,
Martin R. Stämpfli (11440042), Danya Thayaparan (10173586), Christopher S. Stevenson (10173588), Peiyao Wang (4116649), Matthew F. Fantauzzi (11440033), Spencer D. Revill (11440030), Steven P. Cass (11440021), Fernando M. Botelho (7368626), Kjetil Ask (91350), Joshua J. C. McGrath (11440027), Amir Reihani (11440036), Anna Dvorkin-Gheva (201099), Olivia Mekhael (11440024), Aaron I. Hayat (11440039)   +13 more
core   +1 more source

Subpopulations of blood monocytes in patients with generalized hypoxia

Bulletin of Siberian Medicine, 2019
The aimof the work is to establish general regularities and features of differentiation of blood monocytes into 4 subpopulations in diseases associated with circulatory and respiratory hypoxia.Materials and methods.18 patients with ischemic heart disease (IHD), 12 patients with ischemic cardiomyopathy (ICMP), 14 patients with chronic obstructive ...
S. P. Chumakova, M. V. Vins, O. I. Urazova, D. A. Azarova, V. M. Shipulin, A. S. Pryakhin, E. B. Bukreeva, A. A. Bulanova, A. P. Koshel, E. G. Churina, A. V. Sitnikova, N. P. Garganeeva, V. V. Novitskii   +12 more
openaire   +3 more sources

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

Table_4_Increased Monocyte-Derived CD11b+ Macrophage Subpopulations Following Cigarette Smoke Exposure Are Associated With Impaired Bleomycin-Induced Tissue Remodelling.docx

, 2021
RationaleThe accumulation of macrophages in the airways and the pulmonary interstitium is a hallmark of cigarette smoke-associated inflammation. Notably, pulmonary macrophages are not a homogenous population but consist of several subpopulations. To date,
Martin R. Stämpfli (11440042), Danya Thayaparan (10173586), Christopher S. Stevenson (10173588), Peiyao Wang (4116649), Matthew F. Fantauzzi (11440033), Spencer D. Revill (11440030), Steven P. Cass (11440021), Fernando M. Botelho (7368626), Kjetil Ask (91350), Joshua J. C. McGrath (11440027), Amir Reihani (11440036), Anna Dvorkin-Gheva (201099), Olivia Mekhael (11440024), Aaron I. Hayat (11440039)   +13 more
core   +1 more source

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

Aconitate decarboxylase 1 mediates the acute airway inflammatory response to environmental exposures

Frontiers in Immunology
BackgroundEnvironmental lipopolysaccharide (LPS) and microbial component-enriched organic dusts cause significant lung disease. These environmental exposures induce the recruitment and activation of distinct lung monocyte/macrophage subpopulations ...
Aaron D. Schwab, Amy J. Nelson, Angela M. Gleason, Oliver W. Schanze, Todd A. Wyatt, Todd A. Wyatt, Todd A. Wyatt, Dhananjay D. Shinde, Peng Xiao, Vinai C. Thomas, Chittibabu Guda, Kristina L. Bailey, Kristina L. Bailey, Tammy Kielian, Geoffrey M. Thiele, Geoffrey M. Thiele, Jill A. Poole   +16 more
doaj   +1 more source