Results 71 to 80 of about 176,233 (276)

Interstitial macrophage phenotypes in Schistosoma-induced pulmonary hypertension

Frontiers in Immunology
BackgroundSchistosomiasis is a common cause of pulmonary hypertension (PH) worldwide. Type 2 inflammation contributes to the development of Schistosoma-induced PH. Specifically, interstitial macrophages (IMs) derived from monocytes play a pivotal role by
Rahul Kumar, Rahul Kumar, Sushil Kumar, Claudia Mickael, Dara Fonseca Balladares, Dara Fonseca Balladares, Kevin Nolan, Kevin Nolan, Michael H. Lee, Michael H. Lee, Linda Sanders, Julia Nilsson, Ari B. Molofsky, Rubin M. Tuder, Kurt R. Stenmark, Brian B. Graham, Brian B. Graham   +16 more
doaj   +1 more source

Identification of a monocyte phagocytic defect in a subpopulation of patients with nephritis

Kidney International, 1983
Experimental studies have demonstrated the cardinal role played by the mononuclear phagocyte system in the removal of antigen-antibody complexes. To assess the functional capacity of phagocytes in patients with renal disease, 33 normal subjects, 10 patients with mesangial proliferative glomerulonephritis, 8 patients with membranous nephropathy, and 8 ...
Ooi, Yuet M., Ooi, Boon S.
openaire   +2 more sources

Multifunctional Neutrophil Nanovesicles Induce Remodeling of Tumor Immune Microenvironment and Synergistic Multimodal Tumor Therapy

Advanced Functional Materials, EarlyView.
Schematic illustration of the engineered RN@FDT for multimodal tumor therapy. a) Fabrication of FD&DOX/TFA‐loaded RGD‐NNV (RN@FDT) and the light‐triggered disassemble of RN@FDT. b) After internalized by tumor cells, RN@FDT are disintegrated under NIR‐II laser irradiation to boost PTT and induce cell apoptosis.
Jiahui Zhang, Cheng Ji, Xin‐Jian Fang, Yu Qian, Jiayuan Shi, Wenhui Liu, Baiyuan Fan, Yuan Zhong, Jiayi Wang, Dan Yu, Maoye Wang, Min Fu, Xiaoxin Zhang, Runbi Ji, Hélder A. Santos, Hongbo Zhang, Xu Zhang   +16 more
wiley   +1 more source

Possible role of platelet-monocyte complexes in the pathogenesis of recurrent pregnancy loss

Медицинская иммунология
Recurrent pregnancy loss (RPL) is a significant clinical problem that affects 1-5% of population. Moreover, the cause of RPL remains unknown in more than half of cases. Possible reasons include imbalanced maternal hemostasis, thrombosis of uteroplacental
O. V. Pavlov, S. V. Chepanov, E. A. Kornyushina, M. O. Shengeliia, D. V. Tkhai, S. A. Selkov   +5 more
doaj   +1 more source

2‐Deoxyglucose Dendrimer‐Enabled Niclosamide Delivery to FRβ‐Expressing Macrophages Alleviates Endometriosis Progression and Associated Hyperalgesia

Advanced Healthcare Materials, EarlyView.
A folic acid (FA)‐conjugated 2‐deoxyglucose dendrimer selectively targets FRβ+ macrophages in endometriotic lesions, enabling precise intracellular delivery of niclosamide. This nonhormonal nanomedicine enhances drug solubility, provides controlled intracellular release, suppresses lesion growth, reduces inflammation and pain, and establishes FRβ ...
Anubhav Dhull, Mingxin Shi, Madeleine E. Harvey, Taylor M. Page, Rishi Sharma, Kenneth John Goody, Aqib Iqbal Dar, Nash S. Moawad, Vijay Kumar Sirohi, Paul S. Cooke, Kanako Hayashi, Anjali Sharma   +11 more
wiley   +1 more source

Phenotypic characterisation of the monocyte subpopulations in healthy adult pigs and Salmonella-infected piglets by seven-colour flow cytometry

, 2013
The present study describes the distinct bone marrow (BM) and peripheral blood (PB) monocyte subpopulations detected by seven-colour flow cytometry. Mononuclear phagocytes were identified as viable CD172a+ SWC8- CD203a- mononuclear leukocytes. After that,
Domínguez, Javier, Volf, Jiri, Ondrackova, Petra, Matiasovic, J., Faldyna, Martin   +4 more
core   +1 more source

Anisotropic Masked Mycobacterium Potentiates Amplified Antitumor Trained Immunity via Spleen Targeting and Myelopoiesis Conversion

Advanced Materials, EarlyView.
An engineered Trojan Mycobacterium, developed via a “peeling‐off and masking‐up” strategy, functions as a powerful splenic myelopoiesis converter. This spleen‐targeted nanomedicine induces trained immunity to reprogram immunosuppressive myeloid reservoirs into antitumoral effectors.
Jin‐Ho Choi, Sang Nam Lee, Jang Hun Heo, Soyoung Park, Sei Hyun Park, Yong Taik Lim   +5 more
wiley   +1 more source

MOESM2 of Functional analysis of granulocyte and monocyte subpopulations in neonates

, 2019
Additional file 2: Figure S1. A/B Gating strategy for granulocyte and monocyte subpopulations and their activation marker: Representative probe of a new-born infant for activation marker on granulocyte and monocyte subpopulation. After single cell gating
Anja Lange (820723), Ines Hegge (8062142), Johanna Ruhnau (4265836), Antje Vogelgesang (367836), Matthias Heckmann (2887), Ferry Niepel (8062145)   +5 more
core   +1 more source

Table_2_Increased Monocyte-Derived CD11b+ Macrophage Subpopulations Following Cigarette Smoke Exposure Are Associated With Impaired Bleomycin-Induced Tissue Remodelling.docx

, 2021
RationaleThe accumulation of macrophages in the airways and the pulmonary interstitium is a hallmark of cigarette smoke-associated inflammation. Notably, pulmonary macrophages are not a homogenous population but consist of several subpopulations. To date,
Martin R. Stämpfli (11440042), Danya Thayaparan (10173586), Christopher S. Stevenson (10173588), Peiyao Wang (4116649), Matthew F. Fantauzzi (11440033), Spencer D. Revill (11440030), Steven P. Cass (11440021), Fernando M. Botelho (7368626), Kjetil Ask (91350), Joshua J. C. McGrath (11440027), Amir Reihani (11440036), Anna Dvorkin-Gheva (201099), Olivia Mekhael (11440024), Aaron I. Hayat (11440039)   +13 more
core   +1 more source

CD9+ B Cells Induce T Follicular Helper Cell Apoptosis to Regulate Germinal Center Regression

Advanced Science, EarlyView.
A unique subset of CD9+ B cells regulates germinal center B (GC‐B) cell regression by inducing T follicular helper (Tfh) cell apoptosis through multiple signaling pathways, such as ALCAM‐CD6. FOXP1 plays a key role in GC‐B cell differentiation. These findings clarify mechanisms of GC degeneration and termination and offer potential targets for adenoid ...
Wenjing Liao, Lijuan Song, Meiqian Xu, Tianhao Liang, Yixuan Chen, Gui Chen, Zaihuan Lin, Huakang Du, Guofei Feng, Zhiming Feng, Qi Zhang, Fan Pan, Saixuan Yang, Xinyin Zhang, Wenxu Peng, Tianlong Li, Zhuoshen Lin, Yabang Chen, Jiayi Liu, Baoxin Peng, Yan Liu, Xing Niu, Ting Li, Chengyu Huang, Ke Mo, Jianlei Xie, Yu Zou, Xiaowen Zhang   +27 more
wiley   +1 more source