Results 51 to 60 of about 176,233 (276)

Elevation of Non-Classical (CD14+/lowCD16++) Monocytes Is Associated with Increased Albuminuria and Urine TGF-β1 in HIV-Infected Individuals on Stable Antiretroviral Therapy. [PDF]

PLoS ONE, 2016
OBJECTIVE:High rates of albuminuria are observed among HIV-infected individuals on stable antiretroviral therapy (ART). Though pro-inflammatory and pro-fibrotic responses are described as components of albuminuria in the general population, it is unclear
Brooks I Mitchell, Mary Margaret Byron, Roland C Ng, Dominic C Chow, Lishomwa C Ndhlovu, Cecilia M Shikuma   +5 more
doaj   +1 more source

Association between leukocyte subpopulations and hematoma expansion after spontaneous intracerebral hemorrhage: A retrospective cohort study

Frontiers in Neurology, 2022
AimsTo verify the association between leukocyte subpopulations and hematoma expansion (HE) determined by two definitions in Chinese individuals who experienced spontaneous intracerebral hemorrhage.MethodsWe enrolled 471 patients.
Jiao Qin, Jiao Qin, Haihua Wei, Yuling Liu, Lixin Du, Jun Xia   +5 more
doaj   +1 more source

The monocyte system in haematological malignancies [PDF]

, 2020
Monocytes consist of classical, intermediate, and non-classical monocytes. In haematological malignancies, such as multiple myeloma and acute myeloid leukaemia, monocytes are affected by both the disease itself and the treatment patients receive.
Rundgren, Ida Marie
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Classical monocytes from patients with pancreatic ductal adenocarcinoma exhibit a significantly altered transcriptome profile compared with healthy volunteers [PDF]

, 2014
The copyright of this thesis rests with the author and no quotation from it or information derived from it may be published without the prior written consent of the authorPancreatic Ductal Adenocarcinoma (PDAC) affects approximately 8000 people every ...
Cook, Jenny Anne
core   +4 more sources

Functional contribution of elevated circulating and hepatic non-classical CD14CD16 monocytes to inflammation and human liver fibrosis. [PDF]

PLoS ONE, 2010
BackgroundMonocyte-derived macrophages critically perpetuate inflammatory responses after liver injury as a prerequisite for organ fibrosis. Experimental murine models identified an essential role for the CCR2-dependent infiltration of classical Gr1/Ly6C(
Henning W Zimmermann, Sebastian Seidler, Jacob Nattermann, Nikolaus Gassler, Claus Hellerbrand, Alma Zernecke, Jens J W Tischendorf, Tom Luedde, Ralf Weiskirchen, Christian Trautwein, Frank Tacke   +10 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Imaging mass cytometry reveals tissue-specific cellular immune phenotypes in the mouse knee following ACL injury

Osteoarthritis and Cartilage Open, 2023
Objective: To develop an imaging mass cytometry method for identifying complex cell phenotypes, inter-cellular interactions, and population changes in the synovium and infrapatellar fat pad (IFP) of the mouse knee following a non-invasive compression ...
Sanique M. South, M. Caleb Marlin, Padmaja Mehta-D'souza, Tayte Stephens, Taylor Conner, Kevin G. Burt, Joel M. Guthridge, Carla R. Scanzello, Timothy M. Griffin   +8 more
doaj   +1 more source

Different HBV DNA, HBeAg and HBsAg levels do not alter the frequency of monocyte subpopulations.

, 2014
Whole blood samples from chronic HBV patients were stained for CD14 and CD16 to analyze frequencies of the monocyte CD14++CD16− and CD14+CD16+ subpopulations.
Zwier M. Groothuismink (563332), André Boonstra (121511), Gertine W. van Oord (563333), Andrea M. Woltman (357972), Arjan Boltjes (563331), Harry L. A. Janssen (121505)   +5 more
core   +1 more source