Influenza virus A infection of human monocyte and macrophage subpopulations reveals increased susceptibility associated with cell differentiation [PDF]
, 2012 Influenza virus infection accounts for significant morbidity and mortality world-wide. Interactions of the virus with host cells, particularly those of the macrophage lineage, are thought to contribute to various pathological changes associated with poor
Jackson David +27 more
core +1 more source
Monocyte-related gene biomarkers for latent and active tuberculosis
, 2021 Monocytes are closely associated with tuberculosis (TB). Latent tuberculosis in some patients gradually develops into its active state. This study aimed to investigate the role of hub monocyte-associated genes in distinguishing latent TB infection (LTBI)
Jie He (132999) +2 more
core +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Clinical significance of monocyte heterogeneity
Clinical and Translational Medicine, 2015 Monocytes are primitive hematopoietic cells that primarily arise from the bone marrow, circulate in the peripheral blood and give rise to differentiated macrophages.
Brian K Stansfield, David A Ingram
doaj +1 more source
Monocytes and cancer: promising role as a diagnostic marker and application in therapy
Бюллетень сибирской медицины, 2019 Interrelationship between a malignant tumor and the immunity are provided by the involvement of both adaptive and innate immune systems. Monocytes are major participants in nonspecific immune response and mediate their key function through refilling the ...
M. R. Patysheva +7 more
doaj +1 more source
Journal of Cardiovascular Development and Disease, 2022 The differential contribution of monocyte subsets expressing the C-C chemokine receptor 2 (CCR2) to subclinical atherosclerosis in girls and boys is unclear.
María José Garcés-Hernández +11 more
doaj +1 more source
Expression of Tie2 (angiopoietin receptor) on the monocyte subpopulations from ischemic stroke patients: Histological and flowcytometric studies [PDF]
, 2023 Introduction. Different subpopulations of monocytes play roles in phagocytosis, inflammation, and angiogenic processes e.g., Tie2-expressing monocytes (TEMs).
Alrafiah, Aziza R.
core +1 more source
Subpopulation composition of monocytes and inflammation markers in schizophrenia
European Psychiatry, 2023 INTRODUCTION: Taking into account the role of the immune system in the pathogenesis of schizophrenia, it is important to study the peculiarities of innate immunity in the development of the disease. A special role in these processes belongs to monocytes, which play an integral role in the inflammatory reactions and perform regulatory and effector ...
S. A. Zozulya +4 more
openaire +2 more sources
Monocyte Subpopulation Recovery as Predictors of Hematopoietic Cell Transplantation Outcomes [PDF]
Biology of Blood and Marrow Transplantation, 2019 Monocyte recovery after hematopoietic cell transplantation (HCT) has been correlated with overall survival (OS). However, monocytes are heterogeneous and consist of classic (CD14++CD16-), intermediate (CD14+CD16+), and nonclassic (CD14+CD16++) subpopulations, with unique functional properties.
Lucie M. Turcotte +11 more
openaire +2 more sources
Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong +10 more
wiley +1 more source