Results 81 to 90 of about 176,233 (276)

Molecular Characterization of Monocyte Subsets Reveals Specific and Distinctive Molecular Signatures Associated With Cardiovascular Disease in Rheumatoid Arthritis

Frontiers in Immunology, 2019
Objectives: This study, developed within the Innovative Medicines Initiative Joint Undertaking project PRECISESADS framework, aimed at functionally characterize the monocyte subsets in RA patients, and analyze their involvement in the increased CV risk ...
Patricia Ruiz-Limon, Rafaela Ortega-Castro, Nuria Barbarroja, Nuria Barbarroja, Carlos Perez-Sanchez, Christophe Jamin, Alejandra Maria Patiño-Trives, Maria Luque-Tevar, Alejandro Ibáñez-Costa, Laura Perez-Sanchez, Iván Arias de la Rosa, MaCarmen Abalos-Aguilera, Yolanda Jimenez-Gomez, Jerusalem Calvo-Gutierrez, Pilar Font, Alejandro Escudero-Contreras, Marta E. Alarcon-Riquelme, Eduardo Collantes-Estevez, Chary López-Pedrera, the PRECISESADS Clinical Consortium and Flow Cytometry Study Group, C Marañón, L Le Lann, N Varela, B Muchmore, A Dufour, Alvarez, C Carlo Montserrat Chizzolini, E, NB De Langhe, CL-P, V Gerl, A De Groof, J Ducreux, E Trombetta, T Li, D Alvarez-Errico, S Rao, JO Pers, L Beretta, R AguilarQuesada, MA Aguirre-Zamorano, JL Callejas Rubio, MC Castro-Villegas, R Cervera, C Chizzolini, E Collantes, D Cornec, E De Langhe, V Devauchelle-Pensec, AE-C, G Espinosa, MC Fernández Roldán, T Gomes Anjos, F Hiepe, I Jiménez Moleón, S Jousse-Joulin, B Lauwerys, A López-Berrio, R Lories, J Marovac, PL Meroni, B Miranda, H Navarro-Linares, R Ortega-Castro, N Ortego, JO Pers, E Ramón Garrido, E Raya, R Ríos Fernández, I Rodríguez-Pintó, A Saraux   +69 more
doaj   +1 more source

Table_1_Increased Monocyte-Derived CD11b+ Macrophage Subpopulations Following Cigarette Smoke Exposure Are Associated With Impaired Bleomycin-Induced Tissue Remodelling.docx

, 2021
RationaleThe accumulation of macrophages in the airways and the pulmonary interstitium is a hallmark of cigarette smoke-associated inflammation. Notably, pulmonary macrophages are not a homogenous population but consist of several subpopulations. To date,
Martin R. Stämpfli (11440042), Danya Thayaparan (10173586), Christopher S. Stevenson (10173588), Peiyao Wang (4116649), Matthew F. Fantauzzi (11440033), Spencer D. Revill (11440030), Steven P. Cass (11440021), Fernando M. Botelho (7368626), Kjetil Ask (91350), Joshua J. C. McGrath (11440027), Amir Reihani (11440036), Anna Dvorkin-Gheva (201099), Olivia Mekhael (11440024), Aaron I. Hayat (11440039)   +13 more
core   +1 more source

CCR1 and CCR2 Coexpression on Monocytes Is Nonredundant and Delineates a Distinct Monocyte Subpopulation

The Journal of Immunology
Abstract The interactions between chemokines and their receptors, particularly in the context of inflammation, are complex, with individual receptors binding multiple ligands and individual ligands interacting with multiple receptors. In addition, there are numerous reports of simultaneous coexpression of multiple inflammatory chemokine ...
Laura Medina-Ruiz, Robin Bartolini, Heather Mathie, Heba A Halawa, Madeleine Cunningham, Gerard J Graham   +5 more
openaire   +2 more sources

Identification and characterization of a novel monocyte subpopulation in human peripheral blood [PDF]

Blood, 1989
Abstract With the aid of two-color immunofluorescence and flow cytometry, a new subset of cells coexpressing CD14 and CD16 antigens can be identified in human peripheral blood. Using the monoclonal antibody My4, these CD14+/CD16+ cells account for 2.2% of the mononuclear cells and form about 13% of all cells identified by the monocyte ...
B, Passlick, D, Flieger, H W, Ziegler-Heitbrock   +2 more
openaire   +3 more sources

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

Expression of phenotypic markers on monocyte subpopulations.

, 2013
PBMCs from non-pregnant (Non-P), normal pregnant (NP), and pre-eclampsia (PE) patients were stained with anti-CD14-AlexaFluor700, anti-CD16-eFluor450, anti-CCR2-PE, anti-CCR5-FITC, anti-HLA-DR-PerCP-Cy5.5, anti-TIE2-APC, anti-TLR2-FITC, and anti-TLR4-PE ...
Seth B. Coffelt (156668), Ebtisam Al-ofi (313960), Dilly O. Anumba (313961)   +2 more
core   +1 more source

Image_6_Increased Monocyte-Derived CD11b+ Macrophage Subpopulations Following Cigarette Smoke Exposure Are Associated With Impaired Bleomycin-Induced Tissue Remodelling.tif

, 2021
RationaleThe accumulation of macrophages in the airways and the pulmonary interstitium is a hallmark of cigarette smoke-associated inflammation. Notably, pulmonary macrophages are not a homogenous population but consist of several subpopulations. To date,
Martin R. Stämpfli (11440042), Danya Thayaparan (10173586), Christopher S. Stevenson (10173588), Peiyao Wang (4116649), Matthew F. Fantauzzi (11440033), Spencer D. Revill (11440030), Steven P. Cass (11440021), Fernando M. Botelho (7368626), Kjetil Ask (91350), Joshua J. C. McGrath (11440027), Amir Reihani (11440036), Anna Dvorkin-Gheva (201099), Olivia Mekhael (11440024), Aaron I. Hayat (11440039)   +13 more
core   +1 more source

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, EarlyView.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source

Table_3_Increased Monocyte-Derived CD11b+ Macrophage Subpopulations Following Cigarette Smoke Exposure Are Associated With Impaired Bleomycin-Induced Tissue Remodelling.docx

, 2021
RationaleThe accumulation of macrophages in the airways and the pulmonary interstitium is a hallmark of cigarette smoke-associated inflammation. Notably, pulmonary macrophages are not a homogenous population but consist of several subpopulations. To date,
Martin R. Stämpfli (11440042), Danya Thayaparan (10173586), Christopher S. Stevenson (10173588), Peiyao Wang (4116649), Matthew F. Fantauzzi (11440033), Spencer D. Revill (11440030), Steven P. Cass (11440021), Fernando M. Botelho (7368626), Kjetil Ask (91350), Joshua J. C. McGrath (11440027), Amir Reihani (11440036), Anna Dvorkin-Gheva (201099), Olivia Mekhael (11440024), Aaron I. Hayat (11440039)   +13 more
core   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source