Results 71 to 80 of about 940,972 (387)

Expression regulation of MAO isoforms in monocytic cells in response to Th2 cytokines [PDF]

, 2005
Background: Th2-cytokines, such as interleukins-4 and –13 (IL-4, IL-13), have been identified as alternative stimuli of monocytes/macrophages. We have recently profiled the gene-expression pattern of IL-4-teated human peripheral monocytes and found that ...
Billett, E, Chaitidis, P, Kuban, RJ, Kuhn, H, Ungethuem, U   +4 more
core  

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

Journal of Experimental Medicine, 2012
Deep vein thrombosis initiation is mediated by cross talk between monocytes, neutrophils, and platelets.
Marie-Luise von Brühl, K. Stark, Alexander Steinhart, S. Chandraratne, Ildiko Konrad, M. Lorenz, A. Khandoga, A. Tirniceriu, R. Coletti, Maria Koellnberger, Robert A. Byrne, I. Laitinen, A. Walch, A. Brill, S. Pfeiler, D. Manukyan, S. Braun, Philipp Lange, Julia Riegger, J. Ware, Annekathrin Eckart, Selgai Haidari, M. Rudelius, C. Schulz, Katrin Echtler, V. Brinkmann, M. Schwaiger, K. Preissner, D. Wagner, N. Mackman, B. Engelmann, S. Massberg   +31 more
semanticscholar   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Stimulatory and inhibitory activity of STING ligands on tumor-reactive human gamma/delta T cells

OncoImmunology, 2022
Ligands for Stimulator of Interferon Genes (STING) receptor are under investigation as adjuvants in cancer therapy. Multiple effects have been described, including induction of immunogenic cell death and enhancement of CD8 T-cell mediated anti-tumor ...
Ruben Serrano, Marcus Lettau, Michal Zarobkiewicz, Daniela Wesch, Christian Peters, Dieter Kabelitz   +5 more
doaj   +1 more source

Synergistic Chromatin-Modifying Treatments Reactivate Latent HIV and Decrease Migration of Multiple Host-Cell Types

Viruses, 2021
Upon infection of its host cell, human immunodeficiency virus (HIV) establishes a quiescent and non-productive state capable of spontaneous reactivation.
Alexandra Blanco, Tarun Mahajan, Robert A. Coronado, Kelly Ma, Dominic R. Demma, Roy D. Dar   +5 more
doaj   +1 more source

Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo. [PDF]

, 2011
Based on its capacity to inhibit in vitro HIV-1 replication in T cells and the release of pro-inflammatory cytokines in monocytes, the prenylated heterodimeric phloroglucinyl α-pyrone arzanol was identified as the major anti-inflammatory and anti-viral ...
Appendino G, Bauer J, Dehm F, Koeberle A, Northoff H, Pollastro F, ROSSI, ANTONIETTA, SAUTEBIN, LIDIA, Werz O.   +8 more
core   +1 more source

Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

Nature Communications, 2016
Self-renewing tissue-resident macrophages are thought to be exclusively derived from embryonic progenitors. However, whether circulating monocytes can also give rise to such macrophages has not been formally investigated.
Charlotte L. Scott, Fang Zheng, P. De Baetselier, L. Martens, Y. Saeys, Sofie De Prijck, S. Lippens, C. Abels, S. Schoonooghe, G. Raes, N. Devoogdt, B. Lambrecht, A. Beschin, M. Guilliams   +13 more
semanticscholar   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

TLRs1-10 Protein Expression in Circulating Human White Blood Cells during Bacterial and COVID-19 Infections

Journal of Innate Immunity
Introduction: Toll-like receptors play crucial roles in the sepsis-induced systemic inflammatory response. Septic shock mortality correlates with overexpression of neutrophilic TLR2 and TLR9, while the role of TLR4 overexpression remains a debate.
Louise Chomel, Mathieu Vogt, Julien Demiselle, Pierrick Le Borgne, Marine Tschirhart, Valentin Morandeau, Hamid Merdji, Laurent Miguet, Julie Helms, Ferhat Meziani, Laurent Mauvieux   +10 more
doaj   +1 more source

Impact of diabetes mellitus on immunity to latent tuberculosis infection

Frontiers in Clinical Diabetes and Healthcare, 2023
Tuberculosis (TB) is an infectious disease that poses a major health threat and is one of the leading causes of death worldwide. Following exposure to Mycobacterium tuberculosis (M.tb) bacilli, hosts who fail to clear M.tb end up in a state of latent ...
Nathella Pavan Kumar, Subash Babu, Subash Babu   +2 more
doaj   +1 more source