Results 61 to 70 of about 102,629 (199)

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

CD69 is a TGF-β/1α,25-dihydroxyvitamin D3 target gene in monocytes [PDF]

, 2013
CD69 is a transmembrane lectin that can be expressed on most hematopoietic cells. In monocytes, it has been functionally linked to the 5-lipoxygenase pathway in which the leukotrienes, a class of highly potent inflammatory mediators, are produced ...
Thea K Wöbke, Thea K. Wöbke, Bernd L. Sorg, Dieter Steinhilber, Wöbke, Thea Katharina, Andreas von Knethen, Bernd L Sorg, Sorg, Bernd L., Knethen, Andreas von, Steinhilber, Dieter   +9 more
core   +1 more source

Phenotype and function of human monocytes remain mainly unaffected by very small superparamagnetic iron oxide particles

Frontiers in Nanotechnology
The field of medical application of organic or inorganic nanoparticles is extensive. Medical nanoparticles offer benefits but pose risks. For safe use in diagnostics and therapy, they should be inert, non-immunogenic, non-aggregating, and avoid long-term
Sari Hussein, Sari Hussein, Anja Andrea Kühl, Laura Golusda, Laura Golusda, Christina Plattner, Nadine Heinze, Nadine Heinze, Gregor Sturm, Christian Freise, Heike Traub, Mathias Schannor, Zlatko Trajanoski, Matthias Taupitz, Britta Siegmund, Daniela Paclik, Daniela Paclik   +16 more
doaj   +1 more source

Markers of inflammation and immunological competence: Assessment in the early postoperative phase of cardiac surgery involving extracorporeal circulation [PDF]

Journal of Medical Biochemistry
Background: To gain insight into the role and relevance of inflammatory and immunological markers in the comprehensive assessment of a patient's immune response to surgical procedures.
Mutevelić Selma, Bajramović-Omeragić Lejla, Šehić Merima, Baljević-Spahić Sumejja, Pehlivanović Kelle Belma, Begović Ermin, Hasanefendić Berina, Mujičić Ermina, Delić-Mašović Marina, Batinić Drago   +9 more
doaj   +1 more source

Predictive Value of Composite Inflammatory Markers for Stroke Prognosis: A Prospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Novel composite inflammatory markers' role in stroke prognosis is understudied, and the best predictor is unclear, requiring further exploration. Objectives This study aimed to systematically evaluate the associations of 6 novel composite inflammatory markers on stroke prognosis.
Bing Wu, Jie‐Jie Li, Jing Jing, Jin‐Xi Lin, Xia Meng, Yong Jiang, Yong‐Jun Wang, Hong‐Qiu Gu   +7 more
wiley   +1 more source

Cell population data analysis for early diagnosis and prognosis of COVID-19: A Case-Control Study [PDF]

Medical Laboratory Journal
Background: Several hematological indicators have been linked to the intensity and course of Coronavirus Disease of 2019 (COVID-19), including platelets, total white blood cell (WBC) count, lymphocytes, neutrophils (as well as the neutrophil-lymphocyte ...
Priyadarshini Kumaraswamy Rajeswaran, Preethi Muthusamy Sundar, Prasanna Nedungadi Kumar, Karthikeyan Shanmugam   +3 more
doaj  

Evaluation of Lipid-Based Transfection in Primary Monocytes Within an Ex Vivo Whole-Blood Model

Biomolecules
Transfection is a fundamental method in biomedical research to study intracellular molecular mechanisms by manipulating target protein expression. Various methods have been developed to deliver nucleic acids into the cells of interest in vitro, with ...
Robin Moolan-Vadackumchery, Lan Zhang, Frank Stüber   +2 more
doaj   +1 more source

Influence of VEGF deprivation upon vascular formation by endothelium in the presence of macrophages

Медицинская иммунология, 2020
Development of angiogenesis depends on the functional state of endothelial cells, as well as on the balanced secretion of cytokines, growth factors and chemokines by endothelial cells and cells of microenvironment.
A. R. Kozyreva, T. Yu. Lvova, K. L. Markova, A. S. Simbirtsev, A. M. Ischenko, S. A. Selkov, D. I. Sokolov   +6 more
doaj   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Establishment of THP-1 Monocytes with Compromised Mitochondrial Functions [PDF]

, 2009
The process of inflammation is important for both normal health and in a number of diseases, such as metabolic disorders, autoimmune diseases, and neurodegenerative diseases. Mitochondria are vital for the functioning of all cells. It had been implicated
Chou, Tzu-wen Joy
core