Results 71 to 80 of about 737,831 (351)

Adipose inflammation: South Asian ethnicity and central obesity are independently associated with higher immune cell recruitment to adipose‐specific media: A pilot study in men

Physiological Reports, 2023
A South Asian (SA) cardiovascular phenomenon exists whereby SAs have excess burden of cardiovascular disease (CVD) despite having low prevalence of recognized CVD risk factors.
Matthew J. Roberts, Malik Hamrouni, Alex J. Wadley, Nicolette C. Bishop   +3 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Expression regulation of MAO isoforms in monocytic cells in response to Th2 cytokines [PDF]

, 2005
Background: Th2-cytokines, such as interleukins-4 and –13 (IL-4, IL-13), have been identified as alternative stimuli of monocytes/macrophages. We have recently profiled the gene-expression pattern of IL-4-teated human peripheral monocytes and found that ...
Billett, E, Chaitidis, P, Kuban, RJ, Kuhn, H, Ungethuem, U   +4 more
core  

The Helicobacter cinaedi antigen CAIP participates in atherosclerotic inflammation by promoting the differentiation of macrophages in foam cells [PDF]

, 2017
open12siopenD'Elios, Mario Milco; Vallese, Francesca; Capitani, Nagaja; Benagiano, Marisa; Bernardini, Maria Lina; Rossi, Mirko; Rossi, Gianpaolo; Ferrari, Mauro; Baldari, Cosima Tatiana; Zanotti, Giuseppe; DE BERNARD, Marina; Codolo, GaiaD'Elios, Mario ...

core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Peripheral Classic and Intermediate Monocyte Subsets as Immune Biomarkers of Systemic Lupus Erythematosus Disease Activity

Acta Medica Indonesiana
Background: Monocytes are evolutionarily preserved innate immune cells that play essential roles in immune response regulation. Three activated monocyte subsets—classical (CD14++CD16–), intermediate (CD14++CD16+), and nonclassical (CD14+CD16++)—are ...
Amaylia Oehadian, Mohammad Ghozali, Sutiadi Kusuma, Lusi Mersiana, Nadia Gita Ghassani, Fransisca Fransisca, Yitzchak Millenard Sigilipu, Andini Kartikasari, Laniyati Hamijoyo   +8 more
doaj   +2 more sources

The Direct Effect of Low-Magnitude High-Frequency Mechanical Vibration on Osteoclast Formation from RAW267.4 Monocytes [PDF]

, 2015
Low-magnitude high-frequency (LMHF) mechanical vibration has been demonstrated to enhance bone formation possibly through inhibition of osteoclastogenesis of bone.
Abraham, Maxwell Antonio
core   +1 more source

Age-dependent expression of DNMT1 and DNMT3B in PBMCs from a large European population enrolled in the MARK-AGE study [PDF]

, 2016
Aging is associated with alterations in the content and patterns of DNA methylation virtually throughout the entire human lifespan. Reasons for these variations are not well understood.
Bacalini, MARIA GIULIA, Bernhardt, Jürgen, Breusing, Nicolle, Bürkle, Alexander, Caiafa, Paola, Calabrese, Roberta, Capri, Miriam, Ciccarone, Fabio, Dollé, Martijn, Franceschi, Claudio, Gonos, Efstathios S, Grubeck Loebenstein, Beatrix, Grune, Tilman, Guastafierro, Tiziana, Hervonen, Antti, Hurme, Mikko, Jansen, Eugène, Koller, Bernhard, Malavolta, Marco, Moreno Villanueva, María, Reale, Anna, Schӧn, Christiane, Sikora, Ewa, Sindlinger, Thilo, Slagboom, P. Eline, Toussaint, Olivier, Zampieri, Michele   +26 more
core   +2 more sources

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

H3K27me3 modulates trained immunity of monocytes in HDM-allergic diseases

Frontiers in Immunology
BackgroundMonocytes have been confirmed to increase in persistently food-allergic children. A phenomenon of innate immune memory, called trained immunity, has also been observed in monocytes from allergic children.
Lingli Han, Lingli Han, Lin Li, Liangjiao Yao, Huaqin Bu, Yajie Tian, Qifan Li, Ke Zhu, Ke Zhu, Haili Yao, Xiaochuan Wang, Maoxiang Qian, Wei Lu, Jinqiao Sun, Jinqiao Sun   +14 more
doaj   +1 more source