Results 81 to 90 of about 102,629 (199)

Dynamic Loading Regulates Meniscus‐Like Matrix Production in Human Mesenchymal Stromal Cell‐Seeded PET Scaffolds

Advanced Healthcare Materials, EarlyView.
Dynamic compression enhances mesenchymal stromal cell proliferation in nonwoven PET scaffolds under chondrogenic differentiation conditions and triggers mechanosensitive transcriptional programs associated with extracellular matrix remodeling. These findings highlight the potential of mechanically stimulated PET scaffolds as a promising platform for ...
Graciosa Quelhas Teixeira, Luisa de Roy, Anna‐Lotta Feldmeier, Mubashir Ahmad, Sofia Pilão, Maria Ahrens, Anita Ignatius, Carsten Linti, Andreas Martin Seitz   +8 more
wiley   +1 more source

Evaluation of Clinical and Hematological Inflammatory Profile in Patients Treated for Oral Squamous Cell Carcinoma - A Prospective Cohort Study

Journal of Indian Academy of Oral Medicine and Radiology
Background: Cancer treatment can lead to significant morbidities that may persist throughout the life of a patient. Over the past 30 years, there has been no improvement in the percentages of morbidity and mortality of oral squamous cell carcinoma (OSCC)
G Chenchulakshmi, Arvind Muthukrishnan, Ravleen Nagi   +2 more
doaj   +1 more source

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

The impact of acute strenuous exercise on TLR2, TLR4 and HLA.DR expression on human blood monocytes induced by autologous serum

, 2010
Acute exercise alters the surface expression of toll-like receptors (TLRs) and HLA.DR on blood monocytes, which could transiently compromise immunity.
O’Connor, Daniel P., Florida-James, Geraint, Booth, Stephen, Spielmann, Guillaume, Simpson, Richard J., O'Connor, Daniel P, McFarlin, Brian K., Florida-James, Geraint D., McFarlin, Brian K, Simpson, Richard J   +9 more
core   +1 more source

Recruitment, Differentiation, and Function of monocytes during Salmonella infection [PDF]

, 2008
Monocytes are a heterogeneous population in the blood with an enormous plasticity whose fate and functions are dictated by the microenvironment. They are phenotypically and functionally related to neutrophils and dendritic cells (DCs) and share an ...
Rydström, Anna
core   +1 more source

Lipoprotein (a) integrates monocyte-mediated thrombosis and inflammation in atherosclerotic cardiovascular disease

Journal of Lipid Research
Elevated levels of lipoprotein (a) [Lp(a)], an apolipoprotein B particle, are causally linked to atherosclerotic cardiovascular disease (ASCVD). Lp(a) is thought to promote ASCVD through multiple mechanisms, including its effects on cholesterol transport,
Robert S. Rosenson, Ashley M. Tate, Olga G. Grushko, Dilna Damodaran, Qinzhong Chen, Michael Boffa, Marlys Koschinsky, Jagat Narula, Sascha N. Goonewardena   +8 more
doaj   +1 more source

EFFECTS OF BACTERIAL LIGANDS OF PATTERN-RECOGNIZING RECEPTORS (PRR) ON MONOCYTE-LIKE THP-1 CELLS UPON THEIR TRANSENDOTHELIAL MIGRATION

Медицинская иммунология, 2014
. The aim of study was to compare the influence of lipopolysaccharide (LPS) component from Gram-negative bacteria (E. coli 055:B5), and a lysate of Gram-positive bacterium (Streptococcus pyogenes, type M1, strain 40/58) upon transendothelial migration ...
E. P. Starikova, D. I. Sokolov, L. A. Burova, S. A. Sel’kov, I. S. Freidlin   +4 more
doaj   +1 more source

2‐Deoxyglucose Dendrimer‐Enabled Niclosamide Delivery to FRβ‐Expressing Macrophages Alleviates Endometriosis Progression and Associated Hyperalgesia

Advanced Healthcare Materials, EarlyView.
A folic acid (FA)‐conjugated 2‐deoxyglucose dendrimer selectively targets FRβ+ macrophages in endometriotic lesions, enabling precise intracellular delivery of niclosamide. This nonhormonal nanomedicine enhances drug solubility, provides controlled intracellular release, suppresses lesion growth, reduces inflammation and pain, and establishes FRβ ...
Anubhav Dhull, Mingxin Shi, Madeleine E. Harvey, Taylor M. Page, Rishi Sharma, Kenneth John Goody, Aqib Iqbal Dar, Nash S. Moawad, Vijay Kumar Sirohi, Paul S. Cooke, Kanako Hayashi, Anjali Sharma   +11 more
wiley   +1 more source

Generation of decellularized human brain tissue for investigating cell-matrix interactions: a proof-of-concept study

Frontiers in Bioengineering and Biotechnology
The brain extracellular matrix (ECM) regulates myelin repair and regeneration following a demyelinating event by interacting with neuronal progenitors and immune cells. Therefore, generation and characterization of decellularized human brain tissue (DHBT)
Roemel Jeusep Bueno, Roemel Jeusep Bueno, Roemel Jeusep Bueno, Camila Fernández-Zapata, Maren Salla, Maren Salla, Maren Salla, Juliana Campo Garcia, Aylin Alacam, Oliver Klein, Chotima Böttcher, Helena Radbruch, Friedemann Paul, Sarah C. Starossom, Rafaela V. Silva, Carmen Infante-Duarte   +15 more
doaj   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source