Results 81 to 90 of about 940,972 (387)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Differential Accumulation and Activation of Monocyte and Dendritic Cell Subsets in Inflamed Synovial Fluid Discriminates Between Juvenile Idiopathic Arthritis and Septic Arthritis

Frontiers in Immunology, 2020
Despite their distinct etiology, several lines of evidence suggest that innate immunity plays a pivotal role in both juvenile idiopathic arthritis (JIA) and septic arthritis (SA) pathophysiology. Indeed, monocytes and dendritic cells (DC) are involved in
Maïlys Cren, Nadège Nziza, Nadège Nziza, Aurélia Carbasse, Perrine Mahe, Emilie Dufourcq-Lopez, Marion Delpont, Hugues Chevassus, Hugues Chevassus, Mirna Khalil, Mirna Khalil, Thibault Mura, Isabelle Duroux-Richard, Florence Apparailly, Florence Apparailly, Eric Jeziorski, Eric Jeziorski, Pascale Louis-Plence   +17 more
doaj   +1 more source

Myeloid masquerade: Microglial transcriptional signatures in retinal development and disease

Frontiers in Cellular Neuroscience, 2023
Microglia are dynamic guardians of neural tissue and the resident immune cells of the central nervous system (CNS). The disease-associated microglial signature (DAM), also known as the microglial neurodegenerative phenotype (MGnD), has gained significant
Kristen M. Pitts, Kristen M. Pitts, Milica A. Margeta, Milica A. Margeta   +3 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Targeting Interactions between Fibroblasts and Macrophages to Treat Cardiac Fibrosis

Cells
Excessive extracellular matrix (ECM) deposition is a defining feature of cardiac fibrosis. Most notably, it is characterized by a significant change in the concentration and volume fraction of collagen I, a disproportionate deposition of collagen ...
Bo Yang, Yan Qiao, Dong Yan, Qinghang Meng   +3 more
doaj   +1 more source

Circulating miRNA-19b as a biomarker of disease progression and treatment response to baricitinib in rheumatoid arthritis patients through miRNA profiling of monocytes

Frontiers in Immunology, 2023
IntroductionA number of studies have demonstrated a key role of miRNA isolated from cells, tissue or body fluids as disease-specific biomarkers of autoimmune rheumatic diseases including rheumatoid arthritis (RA) and systemic sclerosis (SSc).
Marzena Ciechomska, Leszek Roszkowski, Tomasz Burakowski, Magdalena Massalska, Anna Felis-Giemza, Adria-Jaume Roura, Adria-Jaume Roura   +6 more
doaj   +1 more source

Autophagy generates citrullinated peptides in human synoviocytes: a possible trigger for anti-citrullinated peptide antibodies [PDF]

, 2016
OBJECTIVES: Autophagy may represent a functional processing event that creates a substrate for autoreactivity. In particular, autophagy may play a role in the pathogenesis of RA, since autophagy is a key cellular event involved in the generation of ...
Alessandra Nerviani, Antonella Capozzi, Cristiano Alessandri, Cristina Iannuccelli, Emanuela Lococo, Guido Valesini, Kato, Manuela Di Franco, Maurizio Sorice, Michele Bombardieri, Neumann, Pickl, Roberta Misasi, Tina Garofalo, Valeria Manganelli   +14 more
core   +1 more source

Antioxidant and Immunomodulatory Properties of Chia Protein Hydrolysates in Primary Human Monocyte–Macrophage Plasticity [PDF]

, 2022
Álvaro Villanueva, Sergio Montserrat‐de la Paz, Elena Grao‐Cruces, Justo Pedroche, Rocío Toscano, Francisco Millán, María C. Millán-Linares   +6 more
openalex   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Association of the Total White Blood Cell, Neutrophils, and Monocytes Count With the Presence, Severity, and Types of Carotid Atherosclerotic Plaque

Frontiers in Medicine, 2020
Background: Previous studies have indicated that white blood cells (WBCs) might contribute to the development of atherosclerosis. However, the associations of WBCs and WBC subgroups with carotid atherosclerotic plaque (CAP) have not been compared.Methods:
Yanhua Liu, Yongjian Zhu, Wenrui Jia, Dan Sun, Li Zhao, Chen Zhang, Cuicui Wang, Quanjun Lyu, Yuming Chen, Gaiyun Chen, Yacong Bo, Yurong Xing   +11 more
doaj   +1 more source